ocular drug delivery system. R.C.P. Kasegaon

1. OCULAR DRUG DELIVERY SYSTEM
Presented by :- Seema U. Shinde
M.Pharm. First year
Dept. of Pharmaceutics
Rajarambapu college pharmacy
Kasegaon.
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2. INTRODUCTION
 Ocular administration of drug is primarily associated with the
need to treat ophthalmic diseases.
 Eye is most easily accessible site for topical administration of
a medication.
 Ideal ophthalmic drug delivery must be able to sustain the
drug release and to remain in contact of eye for prolong period
of time .
 The unique structure of eye restricts the entry of drug
molecules at the required site of action.
 Major classes of drugs used are
Miotics -cholinergic agent (Ach)
Mydriatics – anticholinergics (atropine)
These drug are meant for local therapy and not for systemic
action
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3. ANOTOMY OF EYE
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4. ANATOMY OF EYE:
 The eye is composed of two components:
 a) Anterior segment : consist of front of one -third of eye that
mainly includes pupil , cornea ,iris ,ciliary body, aqueous humor ,
and lens.
 b) Posterior segment :consists of the back two –thirds of the
eye that includes vitreous humor , retina, choroid, macula , and
optic nerve.
 Human eye: Diameter of 23 mm
 Structure comprises of three layers
 a) Outermost coat :The clear transparent cornea and the
white, opaque sclera.
 b) Middle layer : The iris anteriorly , the choroid posterior, and
the ciliary body at the intermediate part .
 c) Inner layer: Retina
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5. ANOTOMY OF EYE
 Cornea
 Sclera
 Iris
 Lens
 Choroid
 Retina
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Composition of eye :-
Water-98 %, Solid-1.8 %,
organic element- protein 0.67%,
sugar- 0.65 %, NaCl- 0.66 %,
other mineral element – sodium ,
potassium and ammonia-0.79%

6. MECHANISM OF OCULAR ABSORPTION
 Non –Corneal absorption :
 penetration across sclera and conjunctiva in to
intraocular tissues
 Non productive: because penetrated drug is
absorbed by general circulation
 Corneal absorption :
 Outer epithelium : rate limiting barrier, only access
to small ionic and lipophilic molecules.
 Trans cellular transport : transport between
corneal epithelium
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8. PATHWAY OF OCULAR ABSORPTION
DRUG DILIVERY SYSTEM :
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DRUG IN TEAR FLUID
OCULAR
ABSORPTION
CORNEAL
ROUTE
AQUEOS
HUMOR
CONJECTIVAL
AND SCLERAL
ROUTE
OCULAR
TISSUE
SYSTEMATIC
ABORPTION 50-100%
OF DOSE MAJOR
ROUTE –CONJECTIVA
OF EYE , NOSE
MINOR ROUTE –
LACRIMAL DRAINAGE,
GIT, PHARYNX
AQUEOUS HUMOR
ELIMINATION

9. BARRIERS OF DRUG PERMEATION
Capillary endothelium and capillaries iris.
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B) Blood aqueous barriers:
Prevent the passage of large molecule.
A) Blood Retinal Barrier:

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