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Classification of anemia
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anemia classification

  1. 1. -Definition -Classification ANEMIA By: Tassaya Kanyook ID:52112158
  2. 2. <ul><li>ANEMIA IS NEVER NORMAL </li></ul><ul><li>Men: HGB < 13.5 or HCT < 41% </li></ul><ul><li>Women: HGB < 12.0 or HCT < 36% </li></ul>WHAT IS ANEMIA? <ul><li>Definition of Anemia </li></ul><ul><li>Anemia is a decrease in the RBC count, Hgb and/or HCT values as compared to normal reference range for age and sex </li></ul><ul><li>(Also determined by alteration in plasma volume) </li></ul>
  3. 4. CLASSIFICATION OF ANEMIAS 1 2
  4. 5. CLASSIFICATION OF ANEMIAS 1
  5. 6. CLASSIFICATION OF ANEMIAS <ul><li>Hb levels decreased </li></ul><ul><li>MCV normal </li></ul><ul><li>Acute blood loss </li></ul><ul><li>Anemia of chronic disease </li></ul><ul><li>Aplastic anemia </li></ul><ul><li>Hemolytic anemia </li></ul><ul><li>size of erythrocytes is larger than normal </li></ul><ul><li>Megaloblastic anemia – Vitamin B12, Folate deficiency. </li></ul><ul><li>size of erythrocytes is smaller than normal </li></ul><ul><li>Heme synthesis defect </li></ul><ul><ul><li>Iron deficiency anemia </li></ul></ul><ul><ul><li>Anemia of chronic disease </li></ul></ul><ul><li>Thalassemia </li></ul><ul><li>Sideroblastic anemia </li></ul>2
  6. 7. NORMOCYTIC NORMOCHROMIC ANEMIA <ul><li>It includes </li></ul><ul><ul><ul><li>Aplastic anemia due to BM failure </li></ul></ul></ul><ul><ul><ul><li>Blood loss anemia </li></ul></ul></ul><ul><ul><ul><li>Hemolytic anemia </li></ul></ul></ul><ul><li>Is a condition in which the size & Hgb content of RBCs is normal but the number of RBCs is decreased. </li></ul>
  7. 8. MICROCYTIC- HYPOCHROMIC ANEMIA <ul><li>Many RBCs smaller than nucleus of normal lymphocytes </li></ul><ul><li>Increased central pallor. </li></ul><ul><li>Includes </li></ul><ul><ul><li>Iron deficiency anemia </li></ul></ul><ul><ul><li>Thalassemia </li></ul></ul><ul><ul><li>Anemia of chronic disease </li></ul></ul><ul><ul><li>Sideroblastic anemia </li></ul></ul><ul><ul><li>Lead poisoning </li></ul></ul>
  8. 9. <ul><li>Is a condition in which the total body iron content is decreased below a normal level </li></ul><ul><li>This results in a reduced red blood cell and hemoglobin production </li></ul>IRON DEFICIENCY ANEMIA (IDA)
  9. 10. <ul><li>Inherited decrease in alpha or beta globin chain synthesis needed for Hgb A; quantitative defect </li></ul><ul><ul><li>All have microcytic/hypochromic RBCs and target cells </li></ul></ul><ul><li>Genetic mutations classified by: </li></ul><ul><ul><li>↓ beta chains = beta thalassemia…Greek/Italian </li></ul></ul><ul><ul><li>↓ alpha chains = alpha thalassemia…Asian </li></ul></ul>THALASSEMIAS Target cells/Codocytes Beta Alpha
  10. 11. MACROCYTIC NORMOCYTIC ANEMIAS <ul><li>A. MEGALOBLASTIC ANEMIA </li></ul><ul><ul><ul><li>Vitamin B12 deficiency </li></ul></ul></ul><ul><ul><ul><li>Folate deficiency </li></ul></ul></ul><ul><ul><ul><li>Abnormal metabolism of folate and vit B12 </li></ul></ul></ul><ul><li>B. Non megaloblastic anemia </li></ul><ul><ul><ul><li>Liver disease </li></ul></ul></ul><ul><ul><ul><li>Alcoholism </li></ul></ul></ul><ul><ul><ul><li>Post splenoctomy </li></ul></ul></ul><ul><ul><ul><li>Neonatal macrocytosis </li></ul></ul></ul><ul><ul><ul><li>Stress erythropoiesis </li></ul></ul></ul>Wright’s stained blood smear
  11. 12. <ul><li>Macrocytosis due to a deficiency of vitamin B12 or folic acid that causes impaired nuclear maturation </li></ul>MEGALOBLASTIC ANEMIA RBC maturation in microcytic anemias…IDA Normoblastic RBC maturation  normocytic red cells Megaloblastic RBC maturation  macrocytic red cells
  12. 13. <ul><li>http://themedicalpost.net/2010/07/18/the-general-concept-of-anaemias / </li></ul><ul><li>http:// accessmedicine.com/search/searchAMResult.aspx?rootterm=anemias&searchType=1&rootID=64&searchStr=anemia&modifier=yes&subID=180 </li></ul><ul><li>http:// en.wikipedia.org/wiki/Thalassemia </li></ul><ul><li>http:// www.medicinenet.com/anemia/article.htm </li></ul>REFERENCES
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