Talk for meeting with ARPA-E program officer at UC Davis.

1. Microbiomes = Communities of Microbes

2. Host Microbiome Environment (HME)
Host
Microbiome Environment

3. HME Type 1: Nutrient Acquisition
Host
Microbiome
Nutrient
Acquisition

4. Oloton
Corn
Mucilage
Microbiome
Low
N
HME 1: Nutrient Acquisition

5. Host
Microbiome Pathogen
Stress Type 2: Pathogens

6. Ducks
Gut
Microbiome
Flu
Walter
Boyce
Holly
Ganz
Sarah
Hird
Ladan
Daroud
Alana
Firl
HME Type 2: Pathogens

7. Koala
Gut
Microbiome
Chlamydia
&
Antibiotics
Katherine
Dahlhausen
HME Type 2: Pathogens

8. Frogs
Skin
Microbiome
Chytrid
Sonia Ghose
Marina De Leon
HME Type 2: Pathogens

9. HME Type 3: Changing Environment
Host
Microbiome
Changing
Environment

10. HME Type 3: Climate Change
Coral
Microbiome
Temperature,
Pathogens
Raquel
Peixoto

11. HME Type 3: Climate Change
Seagrass
Microbiome
Move into
Ocean
Jenna Lang
Jessica Green
Jay Stachowicz

12. Engineering Microbiomes
We Need
Control
Host
Microbiome Environment

13. Model and
Non-Model Hosts
Step 1: Detailed Characterization of Systems
Core and
Accessory
Microbiomes
Diverse
Environments

14. Step 2: Controlled Reduction of Microbiome
Antibiotics
Antifungals
Phage
Cleaning
Gnotobiotic
Host
Microbiome Environment

15. Microbiome
Step 3: Microbiome Reintroduction
Culture Collection
Bacteria
Archaea
Fungi
Protists
Viruses
Tools
and
Resources
To Make
and Use
Microbiome Transplants Too
Host
Microbiome Environment

16. Microbiome
Step 4: Assessing Introductions/Interactions
Host
Microbiome Environment

17. Microbiome
Step 5: Apply Engineering Principles …
Host
Microbiome Environment
From Lawson et al. 2019
From Busby et al. 2017