Antihypertension

1. Submitted by
Neha Quadri
Roll no: 1601450043
B.Pharm(6th sem)

2.  Definition of hypertension
 Antihypertension
 Classification of antihypertension
 SAR of captopril
 Mechanism of action of captopril
 Common side effects of captopril
 References

3.  Hypertension is another name for high blood pressure. It can
lead to severe complications and increases the risk of heart
disease, stroke, and death.
 Fast facts of hypertension
 Acute causes of high blood pressure include stress
 Lifestyle factors are the best way to address high blood
pressure.

4.  An antihypertensive is a drug used to treat high
blood pressure.
 Classification of blood pressure
 Normal blood Pressure
 120mmhg _80mmHg
 Pre Hypertension B.P
 Stage 1: 150_160mmHg to 100_110mmHg
 Stage 2 : 180_200mmHg to 120_140mmHg
 Post/Chronic B.P
 More than 200mmHg to more than 150mmHg

5. 1. ACE Antagonist :Ace inhibitor prevent an enzyme in our body from
producing angiotensin 2 , decrease the blood pressure .
2. Angiotensin-2 blocker : Have similar effect Ace inhibitor.
3. Beta-adrenergic blocker. Beta blockers, also known as beta-adrenergic
blocking agents, That are medications that reduce your blood pressure.
4.Calcium Channel Blocker : Calcium channel blockers are drugs used to
lower blood pressure.
5. Centrally acting hypertension drugs: Fall in B.P or Maintain B.P
6. Directly acting drugs :Relatively few drug classes are used to treat
hypertension, the newest of which are direct renin inhibitors.
7. Miscellaneous drugs: diuretics and potassium-sparing diuretics, beta
blockers and diuretics

6.  Captopril is a ACE inhibitor.
 It is a orally active analog pyrroline lead analog.
 The N ring must contain a carboxylic acid with carbonyl gp enhance ACE
inhibitor property as well as decrease the angiotensin release.
 The presence of thiomethylene gp at the central of carbon atom (a) and the
presence of methyl gp at the (x) position increase the potency as well as
duration of action.
 The captopril has been approved for the treatment of hypertension , heart
failure etc.
 The brand name of captopril is known as CAPOTEN

8. • Feeling dizzy
• Cough
• Allergic reaction( Face and throat swelling, and can't breath.
• Go to emergency room if this happens.
Tips: This medicine usually taken three times a day

9.  KD Tripathi - Essentials of Medical Pharmacology 6th
Edition, JAYPEE Publications, page no. 540-554.
 Wilson and Gisvold ,Textbook of medicinal chemistry and
pharmaceutical chemistry,12th edition , page no. 637-647.
 Foye Principle of medicinal chemistry seventh edition ,page
no. 719-722.