Anti-Arrthymic drugs

1. Presented by:
Md.Sazzad Husain
&
Mohd.Javed Ali.

2. Contents:
 Introduction.
 Classification.
 Types of Cardiac Arrthymia.
 Diagnostics Test.
 Classification of Anti arrhythmic drugs.
 SAR of Procainamide .
 Mechanism of Procainamide.
 References.

3. Introduction:
 In the arrthyamics disease which irregular heart beat (increase
or decrease heart beat)
Anti –arrthyamics drug:
 These are drugs used for the treatment & control the
arrathyamics condition called anti-arrthyamics drugs.

5. Classification:
1. Normal cardiac rhythm (60 – 100 beats/min )
2. Abnormal cardiac arrthymia (more then 100 beats / min)

6. Types of cardiac Arrthymia:
A. Brady Cardiac (less then 60 beats/min.)
B. Tachycardia (more then 100 beats/min.)
1. Simple Tachycardia (100-150 beats/min.)
2. Paroxysmal Tachycardia (150-200 beats/min.)
3. Flatter Tachycardia (200-250 beats/min)

7. Diagnostic Test:
 Blood Pressure (80/120 mmHg )
 ECG

8. Classification of Anti-arrhythmic drugs:
1. Class - I
2. Class - II
3. Class - III
4. Class - IV
 Class-I (Acts on Na+ channel )
Types of class- I
Class- I (A)
Decrease the concretion of Na+ ion.
Eg- Procainamide
- Disopyramide
Class- I (B)
work on inactivation gate of Na+ ion.
Eg- Tocainide
Class- I (C)
Work on activation channel of Na+ ion.
Eg- Flecainide

9. Class - II agents
It is the - blocker specially - blocker.
E.g.. Propronolol
- Atenolol
Class – III agents
It is K+ channel blocker.
Eg- Ibulilide
- Brelylium
Class IV agents
It is Ca+ ion blocker
Eg- Nifedipine
- Amlodipine

10. SAR of Procainamide:
1. Procainamide is a white crystalline
powder which same Class I agent (class I
-A ) membrane depressent drugs.
2. Procainamide structure is similar to
the Procain local anesthesia but the
diferent of local anesthic .
3. The present of amino alkyl group is the
Procainamide is essential for increase
the duration of action .
4. The brand Name are PROCAN.

11. Mechanism of Procainamide:

12. References:
 K.D Tripathi, “Essential of medical Pharmacology ”
Japee brothers Medical Publishers (P) ltd,New Delhi.
Sixth edition. Page no.508-520.
 Good&Gilman’s,The Pharmacological Basis of
Therapeutics". Laurence Brunton,New York, Twelfth
edition, Page no.815-848.