NIOSOMES

1. NIOSOMES
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P. R.Pote Patil College of Pharmacy, Amravati.
Presented by,
Mr. Nawaz Hakam
T.Y.B.Pharm (V Sem)
Guided By,
Mr. Chetan M.Jain
(Assistant Professor)
M.Pharm (Q.A)

2.  Introduction
 Structure of Niosomes
 Mechanism of Niosomes
 Niosomes v/s liposomes
 Comparison
 Applications
 Advantages
 Conclusion
 References
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Content

3. Niosomes are a novel drug delivery system, in which the
medication is encapsulated in a vesicle. The vesicle is
composed of a bilayer of non-ionic surface active agents and
hence the name niosomes.
 Nios = non ionic surfactant
 somes = vesicles
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INTRODUCTION

4. They are vesicular systems similar to
liposomes that can be used as carriers of
hydrophilic, ampiphilic and lipophilic drugs.
The niosomes are very small, and
microscopic in size.
Their size lies in the nanometric scale.
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Structure of Niosomes
Most surface active agents when immersed in water yield
micellar structures, however some surfactants can yield bilayer
vesicles which are niosomes.
Niosomes may be-
 Unilamellar
 ultilamellar

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7. Advantages
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 Osmotically active
 Increase the stability of the entrapped drug
 Handling and storage of surfactants do not require any
special conditions.
 Can increase the oral bioavailability of drugs
 Can enhance the skin penetration of drugs
 can be used for oral, parenteral as well topical use.
 The surfactants are biodegradable, biocompatible, and
non-immunogenic .
 Improve the therapeutic performance of the drug by
protecting it from the biological environment and
restricting effects to target cells

8. MECHANISMSOF NIOSOMALSKINDELIVERY
Niosomes diffuse from the stratum corneum layer of
skin as a whole
New smaller vesicles are formed in skin
Noisomes interact with stratum corneum with
aggregation, fusion and adhesion to the cell surface
which causes a high thermodynamic activity gradient of
the drug at the vesicle-stratum corneum surface, which
is the driving force for the penetration of lipophilic drugs
across the stratum corneum
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9. Liposomes face problems such as:
1) expensive
2) chemically unstable
Niosomes do not have any of these
problems:
1) Niosomes are made of
uncharged single-chain surfactant
molecules
2) Structure of niosomes is
different from that of liposomes
NIOSOMES V/S LIPOSOMES
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Comparison of Niosomes v/s Liposomes
Niosome Liposome
• Less expensive.
• Chemically stable.
• Non ionic surfactants are used as
drug carriers and which are
safer.
• They do not require special
storage and handling like
liposomes.
• More expensive.
• Chemically unstable.
• The ionic surfactants are used as
drug carriers and which are
relatively toxic.
• They require special storage,
and handling.
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Common method of Preparation of Niosome
Cholesterol + Non – Ionic surfactant
Dissolve in organic solvent
Solution in organic solvent
Drying
Thin film
Dispersion
Niosome suspension
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12.  Anti-neoplastic treatment
 Use in studying immune response
 Niosomes as carriers for haemoglobin
 Transdermal drug delivery
systems utilizing niosomes
 Localized drug action
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APPLICATIONS

13. Niosomes are thoughts to be better candidates drug delivery as
compared to liposomes due to various factors like cost, stability etc.
Various type of drug deliveries can be possible using niosomes like
targeting, ophthalmic, topical, parentral etc.
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CONCLUSION

14. 1. Malhotra, M. and Jain, N.K., 1994. Niosomes as drug
carriers. INDIAN DRUGS-BOMBAY-, 31, pp.81-81.
2. Azeem, A., Anwer, M.K. and Talegaonkar, S., 2009. Niosomes in
sustained and targeted drug delivery: some recent advances. Journal
of drug targeting, 17(9), pp.671-689.
3. Pravinagurjar, N. and Chouksey, S., 2014. Niosome: a promising
pharmaceutical drug delivery. Int J Pharm Drug Anal, 2, pp.425-31.
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REFERENCES

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