Definition tetracycline absorption of tetracycline and bextram gold Drug-drug interaction pharmacokinetics of bextram gold tetracycline adsorption result

1. Impact of pharmacokinetics of
bextrum gold and tetracycline
from drug drug interaction
BY
MD. MYNUL HASAN
SOUTHEAST UNIVERSITY

2. Bextrum Gold
Bextrum Gold is a unique preparation of high potency 32 vitamins and
minerals including Iron, Zinc and Folic acid with complete antioxidant
effects.

3. Tetracycline
Tetracycline is a group of antibiotic that include tetracycline.
Tetracyclines are obtained by fermentation from Streptomyces spp.or by
chemical transformation or natural products.
Chlortetracycline was the first tetracycline discovered, in 1948. Since
then five additional tetracyclines have been isolated or derived
i. oxytetracycline,
ii. tetracycline,
iii. demeclocycline,
iv. doxycycline and
v. minocycline
but only the last four are available for systemic use. Doxycycline and
minocycline are the most frequently prescribed

4. Absorption of Tetracycline and
Bextram gold
• Bioavailability is less than 40% when administered via intramuscular
injection, 100% intravenously, and 60-80% orally (fasting adults).
Food and/or milk reduce GI absorption of oral preparations of
tetracycline by 50% or more.
• Bextram gold administered via orally 100% absorption.

5. Drug Drug interaction
A change in a drug’s effect on the body when the drug is taken together
with a second drug.
A drug-drug interaction can
• delay,
• decrease or
• enhance absorption of either drug.
This can decrease or increase the action of either or both drugs or cause
adverse effects.

6. Pharmacokinetics
Drug tablet
Drug in gut
release
Drug in blood
Adsorption
Drug in tissues
Drug at receptor
distribution
metabolism
No response Unwanted responseDesined response
Sources of drug variability
Drug metabolism Drug in urine /bile
excretion

7. Pharmacokinetic interactions of bextram
gold and tetracycline
• Tetracyclines have a high affinity to form chelates with polyvalent
metallic cations such as Fe+++, Fe++, Al+++, Mg++ and Ca++.
• Potassium and tetracycline may interact and cause very harmful
effects. When these two medicines are taken together, our body may
not process our antibiotic Properly. our blood levels of antibiotic may
decrease and reduce the ability of the medicine to treat our infection.
Chelation:
Tetracycline interacts with iron
or
Ca2+ Unabsorpable complex

8. continue
Vitamin A can interact with tetracyclines
• increase the chance of a serious side effect called intracranial
hypertension
• rise in the pressure of brain fluid
• lead to permanent vision loss.

9. continue
All B complex vitamins, including
• vitamin B6, interfere with the absorption and effectiveness of
antibiotic tetracycline.
• Riboflavin interferes with the absorption and effectiveness of
tetracycline.
• Folic acid, Vitamin B12 and tetracyclin interferes with the absorption
and effectiveness of Tetracycline.

10. continue
• Niacin oral will decrease the level or effect of tetracycline oral by
suppressing bacteria in the stomach that may assist with drug
absorption. This interaction may occur when both drugs are taken by
mouth.
• Tetracycline dent will decrease the level or effect of biotin oral by
suppressing bacteria in the stomach that may assist with drug
absorption

11. • Adsorption:
tetracycline chelate form with metal ion in the stomach . They are absorbtion is
reduce in the presence of bextrum gold.
• Metabolism :
No metabolism
• Excretion:
No problem in excretion

12. RESULT
 Reduced The bioavailability of tetracycline.
 Dose variability.
 Tetracycline become resistance

13. Have any question?

14. Thank you