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04/01/12




EdExcel Additional Science
   Divide and Develop
04/01/12
      Mitosis



  Each daughter cell has
   the same number of
chromosomes and genetic
information as the parent
        (“diploid”)
04/01/12
             Meiosis



 Each daughter cell has half
the number of chromosomes
  of the parent (“haploid”).
04/01/12
               Mitosis vs. Meiosis
Mitosis:                            Meiosis:
2. Used for growth and repair of    2. Used to produce gametes for
   cells                               sexual reproduction
3. Used in asexual reproduction     3. Each daughter cell has half the
4. Cells with identical number of      number of chromosomes of the
   chromosomes and genetic             parent
   information are produced
04/01/12
                     Cell Growth
There are three ways in which a cell might “grow”:


1) Cell division:




2) Cell expansion:




3) Cell specialisation:
04/01/12
              Measuring Growth
Dry mass vs. wet mass
Dry mass is a more accurate measure of mass but it involves
removing all the water from an organism, so wet mass is usually
used instead.
Mass                               Mass
        Plant growth                      Animal growth
04/01/12
      Environmental differences
Clearly, not all differences are due to just our genes (“Nature
vs. Nurture”)…

  Variation due to     Variation due to     Variation due to a
  inheritance only     environment only        bit of both




For example, height is affected by our genes, our hormones
and our diet.
04/01/12
 5 Things needed for Growth in Plants
                   SUNLIGHT
                   Gives the plant energy
                                            NUTRIENTS
                                                Roots
                                                absorb
                                                these from
  WATER                                         the soil
  Travels up
  from the roots



CARBON DIOXIDE
Enters the leaf through small                 …and the right
holes on the underneath                       temperature
04/01/12
       Artificial Plant Hormones
Hormones can be used to help plant growth and the
development of fruit:

1) Auxin                        2) Ethene

This hormone helps              This hormone helps
fruit to develop                fruit to ripen
04/01/12
Performance-Enhancing Drugs



         Reasons for taking
       performance-enhancing
               drugs
04/01/12
        Regeneration of Animals
Plants can easily grow new leaves or stems when one is cut off.
 Animals find this much more difficult. Here are a few
exceptions:
04/01/12
              Stem cell research
Stem cells are cells that have not yet specialised:

                                     These stem cells have the
                                     potential to develop into
                                     any kind of cell. The rest
                                     of the embryo is
                                     destroyed. Most of these
             Embryo                  embryos come from
                                     unused IVF treatments.
Egg and
 sperm                      Cloned
                           embryos

                       The ethical issue:
          Should these embryos be treated as humans?
04/01/12
The Hayflick Limit

   In 1965 I discovered that a human
   cell can only divide around 52 times
    before it shows signs of old age.
   This is called “The Hayflick Limit”.

   Stem cells and cancer cells have no
             Hayflick limit.
04/01/12
                  Making decisions
Some questions cannot be answered by science and need to be
considered on ethical grounds.

Factors that might influence a decision:

• Beliefs/religion
• What does “the right thing” mean?
• “Playing God”
• Risks – acceptable or unacceptable?
• Social and economic contexts
04/01/12
                 Cloning Animals
Method 1 – “Embryo transplants”




 A developing embryo is “split” before the cells specialise and
    the identical embryos are implanted into host mothers.
04/01/12
Selective breeding
  I raise cows. Each type of
 cow is good at a certain job.
  The Friesian cow produces
 large quantities of milk, the
  Jersey cow produces very       Friesian
  nice milk and the Hereford
   cow produces lot of beef.




                                  Jersey

 If, for example, I want lots
  of milk I would only breed
   Friesian cows with each
 other – this is SELECTIVE
         BREEDING.
                                 Hereford
04/01/12
Selective breeding vs. Cloning
            Advantages   Disadvantages



 Cloning




Selective
breeding
04/01/12
Selective breeding vs. Cloning
               Advantages             Disadvantages
            1) Allows large          1) Causes reduced
               numbers of               numbers of alleles
               organisms with good   2) Loss of variation
 Cloning       characteristics to       could harm survival
               be produced              chances if the
            2) Very efficient           environment changes

            1) Produced organisms    1) Causes reduced
               with favoured            numbers of alleles
               characteristics
Selective                            2) Loss of variation
            2) Very efficient and       could harm survival
breeding       economically viable      chances if the
                                        environment changes
04/01/12
                  Gene Therapy
Gene therapy is when a disease is treated by modifying a
person’s “genome” (genetic makeup). Consider the example of
cystic fibrosis, a disease causing lung problems:

                 The patient is anaesthetised

                 They inhale a “vector virus”
                   carrying a normal gene

                 The normal genes enter lung
                            cells

                   Patients feel better for
                       around 4 weeks
Gene therapy can also be used to treat breast cancer but it is
very expensive.
04/01/12
“Designer Babies”




  Should we be able to
  “design” our children?
04/01/12
     Abortion




Should the abortion limit of
24 weeks be lowered to 18?

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Ed divide and develop

  • 2. 04/01/12 Mitosis Each daughter cell has the same number of chromosomes and genetic information as the parent (“diploid”)
  • 3. 04/01/12 Meiosis Each daughter cell has half the number of chromosomes of the parent (“haploid”).
  • 4. 04/01/12 Mitosis vs. Meiosis Mitosis: Meiosis: 2. Used for growth and repair of 2. Used to produce gametes for cells sexual reproduction 3. Used in asexual reproduction 3. Each daughter cell has half the 4. Cells with identical number of number of chromosomes of the chromosomes and genetic parent information are produced
  • 5. 04/01/12 Cell Growth There are three ways in which a cell might “grow”: 1) Cell division: 2) Cell expansion: 3) Cell specialisation:
  • 6. 04/01/12 Measuring Growth Dry mass vs. wet mass Dry mass is a more accurate measure of mass but it involves removing all the water from an organism, so wet mass is usually used instead. Mass Mass Plant growth Animal growth
  • 7. 04/01/12 Environmental differences Clearly, not all differences are due to just our genes (“Nature vs. Nurture”)… Variation due to Variation due to Variation due to a inheritance only environment only bit of both For example, height is affected by our genes, our hormones and our diet.
  • 8. 04/01/12 5 Things needed for Growth in Plants SUNLIGHT Gives the plant energy NUTRIENTS Roots absorb these from WATER the soil Travels up from the roots CARBON DIOXIDE Enters the leaf through small …and the right holes on the underneath temperature
  • 9. 04/01/12 Artificial Plant Hormones Hormones can be used to help plant growth and the development of fruit: 1) Auxin 2) Ethene This hormone helps This hormone helps fruit to develop fruit to ripen
  • 10. 04/01/12 Performance-Enhancing Drugs Reasons for taking performance-enhancing drugs
  • 11. 04/01/12 Regeneration of Animals Plants can easily grow new leaves or stems when one is cut off. Animals find this much more difficult. Here are a few exceptions:
  • 12. 04/01/12 Stem cell research Stem cells are cells that have not yet specialised: These stem cells have the potential to develop into any kind of cell. The rest of the embryo is destroyed. Most of these Embryo embryos come from unused IVF treatments. Egg and sperm Cloned embryos The ethical issue: Should these embryos be treated as humans?
  • 13. 04/01/12 The Hayflick Limit In 1965 I discovered that a human cell can only divide around 52 times before it shows signs of old age. This is called “The Hayflick Limit”. Stem cells and cancer cells have no Hayflick limit.
  • 14. 04/01/12 Making decisions Some questions cannot be answered by science and need to be considered on ethical grounds. Factors that might influence a decision: • Beliefs/religion • What does “the right thing” mean? • “Playing God” • Risks – acceptable or unacceptable? • Social and economic contexts
  • 15. 04/01/12 Cloning Animals Method 1 – “Embryo transplants” A developing embryo is “split” before the cells specialise and the identical embryos are implanted into host mothers.
  • 16. 04/01/12 Selective breeding I raise cows. Each type of cow is good at a certain job. The Friesian cow produces large quantities of milk, the Jersey cow produces very Friesian nice milk and the Hereford cow produces lot of beef. Jersey If, for example, I want lots of milk I would only breed Friesian cows with each other – this is SELECTIVE BREEDING. Hereford
  • 17. 04/01/12 Selective breeding vs. Cloning Advantages Disadvantages Cloning Selective breeding
  • 18. 04/01/12 Selective breeding vs. Cloning Advantages Disadvantages 1) Allows large 1) Causes reduced numbers of numbers of alleles organisms with good 2) Loss of variation Cloning characteristics to could harm survival be produced chances if the 2) Very efficient environment changes 1) Produced organisms 1) Causes reduced with favoured numbers of alleles characteristics Selective 2) Loss of variation 2) Very efficient and could harm survival breeding economically viable chances if the environment changes
  • 19. 04/01/12 Gene Therapy Gene therapy is when a disease is treated by modifying a person’s “genome” (genetic makeup). Consider the example of cystic fibrosis, a disease causing lung problems: The patient is anaesthetised They inhale a “vector virus” carrying a normal gene The normal genes enter lung cells Patients feel better for around 4 weeks Gene therapy can also be used to treat breast cancer but it is very expensive.
  • 20. 04/01/12 “Designer Babies” Should we be able to “design” our children?
  • 21. 04/01/12 Abortion Should the abortion limit of 24 weeks be lowered to 18?