folding about two articles

1. T R A N S L AT I O N O F G E N E T I C
I N F O R M AT I O N , P R O T E I N S , T H E I R
F U N C T I O N A N D S T R U C T U R E
M I G U E L C A S TA Ñ O B OT E R O
M E D I C I N E S T U D E N T

2. TRANSLATION OF GENETIC
INFORMATION, PROTEINS,
THEIR FUNCTION AND
STRUCTURE
Miguel Castaño Botero
Medicine student
BIBLIOGRAPHY
- Osaka university (2017,september
7) Proteins keep a grip on cells.
Sciencedaily. retrived September
9, 2017 from
www.sciencedaily.com/releases/20
17/09/170907103832.htm
- Whitehead Institute for Biomedical
Research (2017, june 14) Elegant
switch controls translation in
transition from egg to embryo.
Sciencedaily. retrived September
9, 2017 from
www.sciencedaily.com/releases/20
17/06/170614210915.htm
- Martinez Sanchez, Lina Maria.
Biología Molecular. 8 ed. Medellín:
UPB. Fac.Medicina
MEDICA
UTILITY
Both of the articles doesnt
have an especific medical
ultility, because both articles
treat with big concepts, but
the same idea of “big
concepts” helps to found and
understant a lot of diseas,
and now in 2017 is most
likely to found a cure or
treatment if first is
understood why it happened
(this is were big conepts the
relevance).
integrins are related with the
unión between cell-cell, so in
a place that the article could
take importance is on the
skin.

3. IN TH
PROTEINS KEEP A GRIP
ON CELLS.
ELEGANT SWITCH
CONTROLS TRANSLATION IN
TRANSITION FROM EGG TO
EMBRYO
 The cells to be funcional
depend of the set of
cells (they need tu be
united) the integrins
acomplish that mision,
but the integrin also
depend of anothers
proteins like the laminin
511 . student
opinion:
The fact that
they are
discovering
new
components of
this structural
complex is
quite good
because it
means a
possible
treatments to
sicknes related
with the
estructural
function of the
cell
 The pass of egg to
embryo involve a lot of
process, one of this is the
regulation that RNAm has
at the moment of
translate proteins
Student opinion:
Knowing the beginning of this
part of life has a important
inlfuence at the moment of
embrionary diseases.
It would be good to see this kind
of study on humans cells
INTRODUCTION
• Proteins are composed by
aminoacids, depending of
which aminoacid, the protein
will have especific
caracteristics like movement
of water or transportation of
charges. Also the proteins
acomplish a lot of functions in
the body, just to mention
some : they regulate the
genetic expresion, make a
important part of the inmune
system.
• The central dogma of
molecular biology ends with
the translation a part were
proteins are produced. This
proces uses a lot of
components like RNAm,
RNAt,RNAr, ribosoms etc.

4. INTRODUCTION
• Proteins are composed by
aminoacids, depending of which
aminoacid, the protein will have
especific caracteristics like
movement of water or transportation
of charges. Also the proteins
acomplish a lot of functions in the
body, just to mention some : they
regulate the genetic expresion, make
a important part of the inmune
system• The translation of the RNAm is what
make posible the existence of proteins

5. PROTEINS KEEP A GRIP ON CELLS
Date: September 7 of 2017
Source : Osaka university

6. PROTEINS KEEP A GRIP ON CELLS
• There are a lot of proteins that interact with de integrins, one of those proteins are the
laminin 511( the one that was being study on the new).
• The laminins are composed by three chains: alpha, beta gama
• The chains that offer the mayority of information, was the chain alpha and gamma

7. PROTEINS KEEP A GRIP ON CELLS
“It is known that the specific domains of the alpha chain (LG1-3) and the gamma chain
are essential for binding to integrin, but scientists are unsure if the gamma chain directly
interacts with integrin or facilitates interaction with LG1-3”
The glutamic acid is important to bend to the integrin
This information is based on another study

8. PROTEINS KEEP A GRIP ON CELLS
• The adhesión between the integrin a laminin ata the end depends of the glutamic acid
and its interactions with a metal
• The function of the gamma chain is the one that stabilizate the complex integrin-
laminin, the gamma chain acompish this mission by creating a union with the metal

9. STUDENT OPINION
The idea of founding de mechanism of
inteaction between these proteins is quite
amazing, they specify that cells define their
function because the cell that is near them,
so this informaiton would be useful for
example to transplants.

10. ELEGANT SWITCH CONTROLS
TRANSLATION IN TRANSITION FROM
EGG TO EMBRYO
Date: june 14 of 2017
Source: Whitehead Institute for
Biomedical Research

11. ELEGANT SWITCH CONTROLS TRANSLATION
IN TRANSITION FROM EGG TO EMBRYO
“When fertilized the egg becomes an embryo, the stashed maternal mRNAs are pressed
into service for a brief window before the embryo starts transcribing its own mRNAs”
This happens on humans on the first 4 division

12. ELEGANT SWITCH CONTROLS TRANSLATION
IN TRANSITION FROM EGG TO EMBRYO
The change of te translation by the
mothers RNAm to the translation
using the RNAm from the embryon,
is made by three PNG kinase
( PNG, PLU, and GNU)

13. ELEGANT SWITCH CONTROLS TRANSLATION
IN TRANSITION FROM EGG TO EMBRYO
“When an egg is activated, levels of another enzyme that adds phosphates to GNU in the
egg precipitously drop, allowing GNU to lose its phosphates and bind to PNG-PLU. Once
together, the trio comprises the PNG kinase that triggers the translational control of the
maternal mRNAs. Because PNG kinase also triggers the break down of GNU, the kinase
self-destructs, which quickly and irreversibly squelches the translation of maternal
mRNAs.”

14. STUDENT OPINION
The translation of RNAm is the base of the
proteins in the body, just knowing how the
embryo how control a moment were the cells
change of RNAm can help with a lot of possible
treatments to embryonary problems
It wolud be great to see this study in humans cells,
because the one of the article was with
Drosophila, and just a chnage on a specie changes
a lot of factors, like porteins, gen expersion, e.t.c

15. MEDICAL UTILITY
Knowing the estructural function of
protein maybe doesnt find a cure for
especific sickness o disease, but what
really does is to give more information ,
and the information gives more ways to
treat by finding a way to use the
laminin 511, for example a use on
transplants, on decrease of an growing
cancer.

16. MEDICAL UTILITY
the RNAm is a important facrtor on the
translataion, also on how the proteins
are expresed and produced (in a
functioal way), so by controling wich
RNAm is expresed (the one of the
mother or the one of the embryon)
during de groing of the embryon, can
help to cure or treata lot of congenital
diseases.

17. BIBLIOGRAPHY
• Osaka university (2017,september 7) Proteins keep a grip on cells. Sciencedaily.
retrived September 9, 2017 from
www.sciencedaily.com/releases/2017/09/170907103832.htm
• Whitehead Institute for Biomedical Research (2017, june 14) Elegant switch controls
translation in transition from egg to embryo. Sciencedaily. retrived September 9, 2017
from www.sciencedaily.com/releases/2017/06/170614210915.htm
• Martinez Sanchez, Lina Maria. Biología Molecular. 8 ed. Medellín: UPB. Fac.Medicina

18. THANKS