molecular lates news

1. Molecular Machine Could Hold Key to More Efficient
Manufacturing.
And
Protein Origami: Quick Folders Are the Best.
José Alejandro Ramírez Quirós
Medicine Student. UPB. 2013

4. INTRODUCCIÓN
The structure of proteins is
so important, these give
them the posibility to have
actives sites, and these
folding proces is guard by
R.E.R and chaperones.

5. MOLECULAR MACHINE COULD HOLD KEY
TO MORE EFFICIENT MANUFACTURING.
Jan. 10, 2013 — journal Science.
Their model: The ribosome. "The
ribosome can put together 20
aminoacids in a second, we only can
link together 4 blocks in 12 hours”.
They said.

6. This innovatión is a micriscopic
mecenic sistem that works, using an
arm, which join together aa, making
an enlongation section.

8.  Their advantage, is that the machines can work in
parallel, now they have millions of this working together.
The next level, is to build more complex molecules, and
some type of proteins never seen. This is a very exciting
possibility for the future.


9. IN MY OPINION…
 I think, that this invent is a
great advance for the
molecular science, because
it gives the possibility to
really create new proteins
ever seen, and in the same
line, we could use them to
produce cellular effects .

10. PROTEIN ORIGAMI: QUICK FOLDERS
ARE THE BEST.
Jan. 31, 2013 — published inPLoS
Computational Biology.
Heidelberg Institute for Theoretical
Studies (HITS) and the University of
Illinois at Urbana Champaign:
chaperones is an example of the
intense machinary in the cell to well
folding process, to repair and
protect a protein.

11. Proteins are elementary building blocks of life, and
all in the body Works, thanks to them. In order to be
functionally the proteins have to fold into a
tridimensional molecule.

12. The damage in this process
could cause diseases like
Alzheimer's or Creutzfeld-
Jakob.

13.  Whit a speed folding process, the protein is less
susceptible to aggregation and has a fast
conformational change.

14.  This study helps in correct
understanding of the protein
properties, and a bigger
knowledge in the form it work
make possible, to design better
investigative methods to make
cellular interactions. Other
advantage is the possibility to
know the age of a protein,
looking its folding speed, this
could help the world of
anthropology.

15. MEDICAL UTILITY:
 Both news impact the pharmacological industry,
because whit the synthetic protein machine, we can
create a completely new protein, and studying the
folding process we could improve the synthetic
protein production.

16. Scientifics could in a few years, build a new receptor,
or a new component that whit an specific structure,
inactivate or activate a genome, a metabolic
process or even induce apoptosis in tumor.

17. I through, the industrial production of drugs
benefits with this contribution, in a long term.

18. In the case of folding process, is an incredible
advance in understanding the protein kinetics, and
these investigation could help to understand the
importance of folding in interaction messenger-
receptor, and in the protect function of chaperones.

19.  B. Lewandowski, G. De Bo, J. W. Ward, M. Papmeyer, S. Kuschel, M. J.
Aldegunde, P. M. E. Gramlich, D. Heckmann, S. M. Goldup, D. M. D'Souza,
A. E. Fernandes, D. A. Leigh. Sequence-Specific Peptide Synthesis by an
Artificial Small-Molecule Machine. Science, 2013.
 DEBÈS Cédric, WANG Minglei, CAETANO-ANOLLÉS Gustavo, GRÄTER
Frauke. Evolutionary Optimization of Protein Folding. PLoS Computational
Biology, 2013; 9 (1)