The document discusses the cerebral cortex. Key points include:
- The cerebral cortex is the outer layer of gray matter covering the cerebral hemispheres. It accommodates an enormous number of neurons through its large surface area of gyri and sulci.
- The cortex has a total surface area of 2,200 cm2 and contains 10-15 billion neurons and 50 billion glial cells. It is organized into six layers and different cortical areas.
- The cortex receives sensory input from the thalamus and other subcortical structures and projects output to various brain regions. It is involved in functions like sensory processing, motor control, and higher cognition.
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Cbr cortex
1. CerebralCerebral
CortexCortex
Won Taek LeeWon Taek Lee,, M.D. Ph.DM.D. Ph.D..
Department of Anatomy,Department of Anatomy,
Yonsei University College of MedicineYonsei University College of Medicine
2. The layer of gray matter coveringThe layer of gray matter covering
the entire surface of cerebral hemispherethe entire surface of cerebral hemisphere
Migration of neurons from inner mantle layer ofMigration of neurons from inner mantle layer of
neural tubeneural tube
Accommodates enormous number of neuronsAccommodates enormous number of neurons
-- Large surface areaLarge surface area accommodatesaccommodates
more neurons than deep nucleimore neurons than deep nuclei
-- Gyri and sulciGyri and sulci also increase surface areaalso increase surface area
-- Laminar organizationLaminar organization also accommodatesalso accommodates
enormous number of neuronsenormous number of neurons
Cerebral CortexCerebral Cortex
3. Numerical DataNumerical Data
Total surface areaTotal surface area: 2200 cm: 2200 cm22
(2.5 ft(2.5 ft22
))
about 1/3 ------ surface areaabout 1/3 ------ surface area
about 2/3 ------ hidden in the sulciabout 2/3 ------ hidden in the sulci
ThicknessThickness: 1.5 mm (V I) - 4.5 mm (M I): 1.5 mm (V I) - 4.5 mm (M I)
Generally, thickest over the crest of the convolutionGenerally, thickest over the crest of the convolution
and, thinnest in the depth of sulciand, thinnest in the depth of sulci
WeightWeight: 600 gm (40 % of total brain weight): 600 gm (40 % of total brain weight)
180 gm --------- neurons180 gm --------- neurons
420 gm --------- glial cells420 gm --------- glial cells
CerebralCerebral CortexCortex
4. Numerical DataNumerical Data
Number of neuronal cells in cerebral cortexNumber of neuronal cells in cerebral cortex
neurons -----------neurons ----------- 10-15 billion10-15 billion
glial cells ----------glial cells ---------- 50 billion50 billion
Estimation of number of cortical neuronsEstimation of number of cortical neurons
von Economo and Koskinas (1925)von Economo and Koskinas (1925) 14.0 billion14.0 billion
Shariff (1953)Shariff (1953) 6.9 billion6.9 billion
Sholl (1956)Sholl (1956) 5.0 billion5.0 billion
Pakkenberg (1966)Pakkenberg (1966) 2.6 billion2.6 billion
CerebralCerebral CortexCortex
9. I.I. Molecular LayerMolecular Layer
II.II. External Granular LayerExternal Granular Layer
III.III. External Pyramidal LayerExternal Pyramidal Layer
Line of Kaes-BechterewLine of Kaes-Bechterew
IV.IV. Internal Granular LayerInternal Granular Layer
Outer band of BaillargerOuter band of Baillarger
- Line of Gennari- Line of Gennari in area 17in area 17
V.V. Internal Pyramidal LayerInternal Pyramidal Layer
Giant pyramidal cell of BetzGiant pyramidal cell of Betz
Inner Band of BaillargerInner Band of Baillarger
VI.VI. Polymorphic LayerPolymorphic Layer
GolgiGolgi NisslNissl WeigertWeigert
10. 1. corticocortical fiber1. corticocortical fiber
association fiberassociation fiber
commissural fibercommissural fiber
2. thalamocortical fiber2. thalamocortical fiber - specific and non-specific- specific and non-specific
3. extrathalamic subcortical fiber3. extrathalamic subcortical fiber
cholinergic fiber - acetylcholinecholinergic fiber - acetylcholine
basal nucleus of Meynertbasal nucleus of Meynert
mesolimbic dopaminergic fiber - dopaminemesolimbic dopaminergic fiber - dopamine
ventral tegmental areaventral tegmental area
serotonergic fiber – serotonine - raphe nucleiserotonergic fiber – serotonine - raphe nuclei
norepinephrinergic fiber - norepinephrinenorepinephrinergic fiber - norepinephrine
nucleus locus ceruleusnucleus locus ceruleus
Cortical Afferent FiberCortical Afferent Fiber
11. Cortical Afferent FiberCortical Afferent Fiber
1. association fiber1. association fiber
2. commissural fiber2. commissural fiber
3. specific3. specific
thalamocortical fiberthalamocortical fiber
4. non-specific4. non-specific
thalamocortical fiberthalamocortical fiber
14. A.A. pyramidal neuronpyramidal neuron
B. excitatoryB. excitatory
granular cellgranular cell
C.C. inhibitoryinhibitory
granular cellgranular cell
1.1. afferentafferent fiberfiber
2.2. efferent fiberefferent fiber
3.3. corticothalamic fibercorticothalamic fiber
Columnar Cortical Unit and Cortical CircuitaryColumnar Cortical Unit and Cortical Circuitary
15. A.A. Homotypical isocortexHomotypical isocortex
-------------- association cortexassociation cortex
B. Heterotypical isocortexB. Heterotypical isocortex
1. granular cortex1. granular cortex
------ primary sensory cortexprimary sensory cortex
V I (17), S I (3), A I (41)V I (17), S I (3), A I (41)
2. agranular cortex2. agranular cortex
------ motor cortexmotor cortex
M I (4), PM (6)M I (4), PM (6)
Regional Variation of Cortical LaminationRegional Variation of Cortical Lamination
18. Phrenology of Gall and SpurzheimPhrenology of Gall and Spurzheim
Clinical evidencesClinical evidences
Broca’s area (1861)Broca’s area (1861)
Jacksonian epilepsy (1864)Jacksonian epilepsy (1864)
Experimental evidencesExperimental evidences
Fritsch and Hitzig (1870) --- motor cortexFritsch and Hitzig (1870) --- motor cortex
von Gudden (1870) ---- visual cortexvon Gudden (1870) ---- visual cortex
Ferrier (1873) ---- auditory cortexFerrier (1873) ---- auditory cortex
Functional Localization of Cerebral CortexFunctional Localization of Cerebral Cortex
21. based on cytoarchitectonic studiesbased on cytoarchitectonic studies
Campbell (1905) --------Campbell (1905) -------- about 20 areasabout 20 areas
Brodmann (1909) ------Brodmann (1909) ------ 47 areas47 areas
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Vogt and Vogt (1919) -Vogt and Vogt (1919) - over 200 areasover 200 areas
von Economo (1929) --von Economo (1929) -- 109 areas109 areas
Morphological Classification of Cortical AreasMorphological Classification of Cortical Areas
24. Sensory areaSensory area
primary sensory areaprimary sensory area
secondary sensory areasecondary sensory area
Motor areaMotor area
primary motor areaprimary motor area
secondary motor areasecondary motor area
supplementary motor areasupplementary motor area
Association areaAssociation area
parietal, occipital and temporal cortexparietal, occipital and temporal cortex
- conceptual elaboration of sensory data- conceptual elaboration of sensory data
prefrontal (frontal) cortexprefrontal (frontal) cortex
- judgement, foresight- judgement, foresight
Functional Localization of Cerebral CortexFunctional Localization of Cerebral Cortex
25. Somesthetic Area (Somesthesia)Somesthetic Area (Somesthesia) S I, S IIS I, S II
Visual Area (vision)Visual Area (vision) V I, V IIV I, V II
Auditory Area (Hearing)Auditory Area (Hearing) A I, A IIA I, A II
Vestibular Area (Equilibrium)Vestibular Area (Equilibrium)
Gustatory Area (Taste)Gustatory Area (Taste)
Olfactory Area (Smell)Olfactory Area (Smell)
Sensory AreasSensory Areas
26. S IS I ----- 3, 1, 2 (postcentral gyrus)----- 3, 1, 2 (postcentral gyrus)
afferernts: ventrobasal complex (VPLc, VPM)afferernts: ventrobasal complex (VPLc, VPM)
discrimination of position and intensity of sensationdiscrimination of position and intensity of sensation
S IIS II ---- superior bank of lateral fissure---- superior bank of lateral fissure
no clinical disordersno clinical disorders
Somesthetic Association CortexSomesthetic Association Cortex
------- 5, 7 (parietal lobule, precuneus)------- 5, 7 (parietal lobule, precuneus)
afferents: S I, LP of thalamusafferents: S I, LP of thalamus
integration of geneal sensation with past experienceintegration of geneal sensation with past experience
tactile agnosia, astereognosistactile agnosia, astereognosis
Somesthetic AreaSomesthetic Area
30. V I -----V I ----- 17 (striate cortex - line of Gennari)17 (striate cortex - line of Gennari)
greatly thickened outer band of Baillargergreatly thickened outer band of Baillarger
heterotypical isocortexheterotypical isocortex
afferent: LGd of thalamusafferent: LGd of thalamus
visual field defect:visual field defect:
homonymous quadranopsia and macular sparinghomonymous quadranopsia and macular sparing
V II ----V II ---- 18, 19 (visual association area)18, 19 (visual association area)
afferents: V I, pulvinar of thalamusafferents: V I, pulvinar of thalamus
integration of vision with past experienceintegration of vision with past experience
visual agnosiavisual agnosia
cf. occipital eye fieldcf. occipital eye field
Visual CortexVisual Cortex
33. A I -----A I ----- 41, 42 (trannsverse temporal gyrus of Heschl)41, 42 (trannsverse temporal gyrus of Heschl)
heterotypical isocortexheterotypical isocortex
afferents: MGv of thalamus - core projectionafferents: MGv of thalamus - core projection
slight diminution in auditory acuityslight diminution in auditory acuity
A II ----A II ---- 22 (Wernike's area of original connotaion)22 (Wernike's area of original connotaion)
not well-definednot well-defined
afferents: non-laminar part (MGm, MGd) – belt projectionafferents: non-laminar part (MGm, MGd) – belt projection
A IA I
auditory agnosia - sensory aphasiaauditory agnosia - sensory aphasia
Auditory CortexAuditory Cortex
36. Vestibular AreaVestibular Area
Area 3a and 2v of S IArea 3a and 2v of S I
afferents: VPLoafferents: VPLo
[superior temporal gyrus anterior to A I][superior temporal gyrus anterior to A I]
Gustatory AreaGustatory Area
Area 43 (inferior end of postcentral gyrus)Area 43 (inferior end of postcentral gyrus)
afferents: VPMpcafferents: VPMpc
Olfactory AreaOlfactory Area
Piriform Lobe - Limbic SystemPiriform Lobe - Limbic System
Other Primary Sensory AreasOther Primary Sensory Areas
37.
38. primary Motor Area (M I)primary Motor Area (M I)
Premotor Area (PM)Premotor Area (PM)
Supplementary Motor Area (SMA)Supplementary Motor Area (SMA)
Frontal Eye FieldFrontal Eye Field
Motor AreasMotor Areas
40. M I ------- 4M I ------- 4
precentral gyrus of lateral surfaceprecentral gyrus of lateral surface
anterior part of paracentral lobuleanterior part of paracentral lobule
heterotypical agranular cortexheterotypical agranular cortex
giant pyramidal cell of Betzgiant pyramidal cell of Betz
afferents: premotor area, SMA, S Iafferents: premotor area, SMA, S I
VLc, VPLo of thalamusVLc, VPLo of thalamus
Motor HomunculusMotor Homunculus
Upper Motor Neuron (UMN) syndromeUpper Motor Neuron (UMN) syndrome
Primary Motor AreaPrimary Motor Area
41. Premotor Area (PM) ------Premotor Area (PM) ------ lateral surface of 6lateral surface of 6
afferents: VLc, VPLo of thalamus from cerebellumafferents: VLc, VPLo of thalamus from cerebellum
Supplementary Motor Area (SMA)Supplementary Motor Area (SMA)
---------------------------------------------------- medial surface of 6medial surface of 6
afferents: VLo, Vapc of thalamus from basal gangliaafferents: VLo, Vapc of thalamus from basal ganglia
Frontal Eye Field ----------Frontal Eye Field ---------- 88
voluntary tracking movementvoluntary tracking movement
Other Motor AreasOther Motor Areas
42. Brodman’s Map of Motor and Sensory AreasBrodman’s Map of Motor and Sensory Areas
43. Language Areas ----- 22, 39, 40, 44, 45Language Areas ----- 22, 39, 40, 44, 45
Posterior Parietal Association AreaPosterior Parietal Association Area
------------ 5, 75, 7 (39, 40)(39, 40)
body imagebody image
Temporal Association AreaTemporal Association Area
------------ 20, 21, 37,20, 21, 37, 3838 (22)(22)
multisensory integration, conceptual ideationmultisensory integration, conceptual ideation
Prefrontal Association AreaPrefrontal Association Area
---------- 9, 10, 11, 12, 46, 479, 10, 11, 12, 46, 47 (44, 45)(44, 45)
judgement, foresight, personalityjudgement, foresight, personality
Association AreasAssociation Areas
44. Order of Cortical MaturationOrder of Cortical Maturation
11
2233
33
33
22
11
11
45. AgnosiaAgnosia
Tactile agnosiaTactile agnosia
Visual agnosiaVisual agnosia
AlexiaAlexia
Auditory agnosiaAuditory agnosia
ApraxiaApraxia
AphasiaAphasia
Wernicke’s (receptive) aphasiaWernicke’s (receptive) aphasia
Broca’s (Motor) aphasiaBroca’s (Motor) aphasia
conduction aphasiaconduction aphasia
global aphasiaglobal aphasia
Disorders of Association CortexDisorders of Association Cortex
46. ApraxiaApraxia
The inability to execute a voluntary motor movement despiteThe inability to execute a voluntary motor movement despite
being able to demonstrate normal muscle function.being able to demonstrate normal muscle function.
47. Sensory Language Area (Wernike's area) ----Sensory Language Area (Wernike's area) ---- 22, 39, 4022, 39, 40
ReceptiveReceptive AphasiaAphasia -- area 22area 22
defect in comprehension, good spontaneous speechdefect in comprehension, good spontaneous speech
AnomicAnomic AphasiaAphasia -- word finding difficultyword finding difficulty
JargonJargon aphasiaaphasia -- fluent, but unintelligiable jargonfluent, but unintelligiable jargon
39 (supramarginal gyrus), 40 (angular gyrus)39 (supramarginal gyrus), 40 (angular gyrus)
Superior Longitudinal FasciculusSuperior Longitudinal Fasciculus
ConductionConduction AphasiaAphasia
good comprehension, good spontaneous speechgood comprehension, good spontaneous speech
poor repetition, poor responsepoor repetition, poor response
Motor Language Area (Broca’s area) --- 44, 45Motor Language Area (Broca’s area) --- 44, 45
MotorMotor ApahsiaApahsia
good comprehension, no speechgood comprehension, no speech
Language AreasLanguage Areas
49. Photograph of the brainPhotograph of the brain
of Paul Broca’s patientof Paul Broca’s patient
called “Tan” (real namecalled “Tan” (real name
is Leborgne).is Leborgne).
Broca’s AreaBroca’s Area
Pars triangularis andPars triangularis and
pars opercularis of thepars opercularis of the
inferior frontal gyrus ofinferior frontal gyrus of
dominant hemisphere.dominant hemisphere.
55. Roger SperryRoger Sperry
(1913-1994)(1913-1994)
1981 Nobel1981 Nobel
LaureateLaureate
Split BrainSplit Brain
CommissuratomyCommissuratomy
(split corpus callosum)(split corpus callosum)
Two minds in one brain?Two minds in one brain?
56. Frontal Granular CortexFrontal Granular Cortex
Lateral Prefrontal Association AreaLateral Prefrontal Association Area
------------ 9, 10, 469, 10, 46
judgement, foresight, problem solvingjudgement, foresight, problem solving
Orbitofrontal CortexOrbitofrontal Cortex
------------ 11, 12, 4711, 12, 47
emotion, olfaction, personalityemotion, olfaction, personality
Case ofCase of Phineas GagePhineas Gage
Prefrontal Leucotomy ofPrefrontal Leucotomy of MonizMoniz andand FreemanFreeman
Prefrontal Association AreasPrefrontal Association Areas