blood

1. Dr. Maria Idrees
PT (TUF)
Ms nmpt (RIU)

2. Composition of RES
 Kupffer cells of liver
 Microglia of brain
 Alveoler macrophages
 Bone marrow lymph nodes
 Macrophages in the intestine

3. Reticulo endothelial cells are found in the following
structures:
 Endothelial lining of vascular and lymph channels
 Connective tissue and some organs like spleen, liver,
lungs, lymph nodes, bone marrow etc.

4. Classification
Classified into 2 types
 Fixed reticuloendothelial cells or tissue macrophages
 Wandering reticuloendothelial cells

5. Fixed reticuloendothelial cells
Also called fixed histiocytes because these cells are usually
located in the tissues.
Tissue macrophages are present in following area
 Connective tissue
 Endothelium of blood sinusoids
 Reticulum
 CNS
 Lungs
 Subcutaneous tissue

6. Wandering reticuloendothelial cells
Also called free histiocytes
 2 types
1. Free histiocytes of blood
Neutrophils
Monocytes
1. Free histiocytes of solid tissue

7. Functions of RES
 Phygocytic function
 Secretion of bactericidal function
 Secretion of IL-1-6-12
 Secretion of TNF
 Secretion of CSF
 Secretion of PDGF
 Removal of carbon particles and silicon
 Destruction of senile RBCs
 Destruction of Hb

8. Gross & microscopic structure