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HIV protease activates waterfor a hydrolysis reactions using what type of two residues?
Solution
The question deals with the action of mechanism of HIV protease.. The main active site for the
lies in the identical sub units which has a sequence of (Asp-Thr-Gly) .. The position of these are
(25-26-27) .
As it is a homodimer hence both the Asp(25) residues act as a catalytic site for this.. The water
plays an important role in the mechanism where water acts as a Nucleophile..
This water along with the (2 -Asp) residues discussed above brings out the mechanism of
breaking or hydrolysis of scissile bonds peptides bonds,(these are covalent bonds which can be
broken by enzymes)..!!
The two residues are 2 - Asp which are at position 25..!

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HIV protease activates waterfor a hydrolysis reactions using what ty.pdf

  • 1. HIV protease activates waterfor a hydrolysis reactions using what type of two residues? Solution The question deals with the action of mechanism of HIV protease.. The main active site for the lies in the identical sub units which has a sequence of (Asp-Thr-Gly) .. The position of these are (25-26-27) . As it is a homodimer hence both the Asp(25) residues act as a catalytic site for this.. The water plays an important role in the mechanism where water acts as a Nucleophile.. This water along with the (2 -Asp) residues discussed above brings out the mechanism of breaking or hydrolysis of scissile bonds peptides bonds,(these are covalent bonds which can be broken by enzymes)..!! The two residues are 2 - Asp which are at position 25..!