PRION DEFINATION STRUCTURE FIBRIL MODEL kEY FEATURE PROPERTIES

1. Prion :
Presented by : Khushbu’ Microbiology

2.  DEFINATION : Misfolded proteins with the ability to transmit their misfolded shape
onto normal variants of the same protein.
 Pronunciation : ˈpriːɒn/ (listen), /ˈpraɪɒn/
 Prion : derives from "proteinaceous infectious particle
 Protein as an infectious agent stands in contrast to all other known infectious agents
such as viruses, bacteria, fungi & parasites all of which contain DNA , RNA or both.

3. Heterodimer model of
prion propagation

5. KEY FEATURES OF PIRONS
 Even smaller than viruses
 (pronounced “pree-ons”)
 simplest infectious agents.
 Like viruses they are obligate parasites,
 no genetic material.
 Although prions are merely self-perpetuating proteins, they have been
implicated as the cause of various diseases including bovine spongiform
encephalopathy (mad cow disease)
 suspected of playing a role in a number of other disorders.

6. PRION :PROPERTIES
 Prion : proteins multiply
 Not broken down by proteases and instead accumulate
within neurons,destroying them.
 Progressive neuron destruction eventually causes
brain tissue to become filled with holes in a spongelike, or
spongiform, pattern.

7. Prion :
Pathogenic type of misfolded protein

8. THANKS