This document summarizes the key differences between prokaryotic and eukaryotic cells. Prokaryotic cells lack a membrane-bound nucleus and organelles, have circular DNA or plasmids instead of chromosomes, are generally unicellular, and are smaller than eukaryotic cells. Eukaryotic cells have a membrane-bound nucleus and organelles, multiple linear chromosomes, can be uni- or multicellular, and are larger than prokaryotic cells. The document provides examples of organisms for each cell type and describes differences in cell structures.