Diagrammatically differences Occurrences Structures Functions Encoded chromosomes Antigen-presenting Domains Responsive Cells

1. Different between MHC class 1 and MHC class 2
Presented by M Kamil Khan
Microbiologist

2. Content
• Diagrammatically differences
• Occurrences
• Structures
• Functions
• Encoded chromosomes
• Antigen-presenting Domains
• Responsive Cells

3. 1. Diagrammatically differences

4. 2. Occurrences
• MHC Class I – They are found on all nucleated cell types in
the body.
• MHC Class II – They are found on antigen presenting cells
like macrophages, dendritic cells, and B cells.

5. 3. Structures
• MHC Class I – They consist of 3 alpha domains and 1
beta domain.
• MHC Class II – They consist of 2 alpha and beta
domains.

6. 4. Function
• MHC Class I – Their main role is to clear endogenous
antigens that comes from the cytoplasm
• MHC Class II – Their main role is to clear exogenous
antigens that comes outside the foreign organisms

7. 5. Encoded Chromosomes
• MHC Class I – Alpha domains are found on the locus
of chromosome 6. On the other hand, beta chains
are found on chromosome 15.
• MHC Class II – They are found on chromosome 6.

8. 6. Antigen-presenting Domains
• MHC Class I – Both alpha 1 and 2 domains have
something to do with the presentation of antigens in
the molecules of MHC class I.
• MHC Class II – Both alpha 1 and beta 2 domains have
something to do with the presentation of antigen in
MHC Class II molecules.

9. 7. Responsive Cells
• MHC Class I – Present antigens to cytotoxic T cells by
binding on CD8 receptor on cytotoxic T cell
• MHC Class II – Present antigens to helper T cells by
binding on CD4 receptor on helper T cell

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