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Think about the similarities and differences that benign (non-cancerous) and malignant
(cancerous) tumors. Which mutations do both malignant and benign tumors most likely have and
what characteristic of the tumor does that mutation cause?
Solution
Similarites
1. Both grow in uncontrolled manner.
2. Both can form tumor even after surgery.
3.Both become dangerous if untreated eg.Begin brain tumor and Lung cancer.
4. Both increases the size of the tumor.
Difference
Benign Maligant
1. Growth rate very slow Growth rate Fast
2. No metastatis Metastatis - Spread to other part of the body
3. No Angiogenesis Angiogenesis - Forming new blood vessels
4. Treatment easy surgery Treatment - Radiation, Chemotherapy etc
5. It is sticky to surface It dont produce any sticky molecule. So, it float and metastatis occur.
APC gene responsible for both Benign and maligant colon cancer. Polyps Precancerous cells
initially evolve inside
of colon wall. After period of time if not treated another mutation happen in ras gene turns into
maligant.
Characteristic of tumor
Rapid growth
Density independent growth
No differentiation
No contact inhibition
No apotosis

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Think about the similarities and differences that benign (non-cancer.pdf

  • 1. Think about the similarities and differences that benign (non-cancerous) and malignant (cancerous) tumors. Which mutations do both malignant and benign tumors most likely have and what characteristic of the tumor does that mutation cause? Solution Similarites 1. Both grow in uncontrolled manner. 2. Both can form tumor even after surgery. 3.Both become dangerous if untreated eg.Begin brain tumor and Lung cancer. 4. Both increases the size of the tumor. Difference Benign Maligant 1. Growth rate very slow Growth rate Fast 2. No metastatis Metastatis - Spread to other part of the body 3. No Angiogenesis Angiogenesis - Forming new blood vessels 4. Treatment easy surgery Treatment - Radiation, Chemotherapy etc 5. It is sticky to surface It dont produce any sticky molecule. So, it float and metastatis occur. APC gene responsible for both Benign and maligant colon cancer. Polyps Precancerous cells initially evolve inside of colon wall. After period of time if not treated another mutation happen in ras gene turns into maligant. Characteristic of tumor Rapid growth Density independent growth No differentiation No contact inhibition No apotosis