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Acid base disorders
1. ACID BASE DISORDERS
DR KALYAN DEBNATH
PHASE -A
Dept of Anaesthesia , Analgesia
& Intensive care medicine
2. Some important definition
Acidaemia: blood PH < 7.35.
Alkalaemia: blood PH > 7.45.
Acidosis: is the abnormal process that
tends to lower the blood PH.
Alkalosis: is the abnormal process that
tends to raise the blood PH.
Mixed disorder: two or more primary
acid base disorder coexist.
3. Compensation: the normal body
process that returns blood PH
towards normal
Buffer: a substance that counteracts
the effect of Acid or Base on blood
PH
Pa02 : is the partial pressure of 02
in arterial blood.
PaC02 : is the partial pressure of
C02 in arterial blood.
HCO3-: is the blood bicarbonate
concentration.
4. PH
An acidaemia (low pH) result from
either a low HCO3(Metabolic) OR high
C02(Respiratory).
An alkalemia (high pH) result from
either a high HCO3(Metabolic) OR low
C02(Respiratory).
5. How body buffers work
Immediately, buffers in
blood(NAHC03) change strong acid to
weak acid.
After several minutes, this weak
acid decomposes to co2 carried by Hb
to be expired by lungs.
After several hours, kidney
smoothly reabsorbs the HCO3
wasted.
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10. Assess oxygenation
Look at oxygenation (pa02 and Sa02)
Look at Pao2/Fio2 ratio
Normally, the ratio is around 1:400-
1:500.
Less than 1:400—sugesstive of V-Q
mismatch or diffusion defect or
intracardiac shunt
Less than 300 with bilateral lung
infiltrate in CXR: ARDS.
11. A-a gradient
A-a gradient= PA02-Pa02
Here, PA02 is alveolar P02 & Pao2 is
arterial P02.
In general, A-a gradient can be calculated
by:
A-a gradient=[Fi02*(Patm-PH20)-
(PaC02/0.8)]-Pao2
On room air & at sea level, Fi02 is
0.21,Patm is 760 mmHg and PH20 is
47 mmHg.
12. On room air , PA02 calculated by:
150-PaC02/0.8
Normal A-a gradient in a 20 year old
person is 5 mmHg which increase to
10 in a 35 year old person. If A-a
gradient is 20 mmHg at any age, is
abnormal .
13. Metabolic Acidosis
Definition
Metabolic acidosis can be defined as
a low arterial blood pH in conjunction
with low serum bicarbonate
concentration caused either by
increased acid generation or
decreased acid secretion or loss of
bicarbonate.
14. Types
A. M. Acidosis with increased anion gap
B. M. Acidosis with normal anion gap (
hyperchloraemic M. acidosis)
It is very important to calculate the Anion
gap if primary disorder is M. acidosis.
Anion Gap= (Na+ + K+) – (Cl- + HCO3)
Normal Anion Gap 12 – 16 mEq/L.
18. Treatment of M.acidosis
Treatment of metabolic acidosis can
vary markedly with underlying
disorder.
In severe metabolic acidosis,
assuming that respiratory function is
normal, a PH of 7.20 would be
reasonable to target and usually
requires rising serum HCO3 to 10 to
12 mEq/L.
Deficit can be calculated by formula:
HCO3 deficit= 0.5*lean body wt*(24-
HCO3)
19. Sodium bicarbonate can be given as oral
tablets, powder as a hypertonic
bicarbonate bolus or isotonic sodium
bicarbonate .For patients with volume
depletion , administration of three
ampoules of bicarbonate (each contain
50mEq of sodium bicarbonate)in 1L of
dextrose 5% in water(5%DA ) solution
will help both volume expansion and
alkalization.
20. Replace 50% of deficit in 1st 24
hours and determine future
dosage based on response to
therapy and target bicarbonate.
Renal replacement therapy is
employed for refractory severe
metabolic acidosis.
21. METABOLIC ALKALOSIS
• Metabolic alkalosis reflects an increase in
plasma HCO3.
• It is due to either gain of HCO3 or
extracellular volume contraction.
• It can be classified into Chloride responsive
or non responsive. for this spot urinary
chloride is to be checked.
• More than 20 mEq/l urinary chloride is
Chloride unresponsive and less than 20
mEq/l urinary chloride is Chloride
responsive.
22. Causes of chloride
responsive m. alkalosis
Vomiting, NG suction
Thiazide
Loop diuretics
Chronic hypercapnoea
Villous adenoma of colon
23. Causes of chloride resistant
m. alkalosis
Mineralocorticoid excess
(hyperaldosteronism, Cushing’s
syndrome, ACTH secreting tumor,
renin secreting tumor)
Bartter syndrome, Gitelmann’s
syndrome
Decreased effective circulating volume
in setting of heart failure / cirrhosis.
Hypokalaemia.
25. Treatment of M. Alkalosis
Chloride responsive alkalosis --
The increase in bicarbonate resorption
can be counteracted by administration
of normal saline or by volume
expansion. Increased distal chloride
delivery will increase the bicarbonate
secretion in CT. effect can be
monitored by increase in urinary pH
(>7).
26. Chloride resistant alkalosis
includes discontinuing diuretics, trail of
acetazolamide, dialysis.
Acetazolamide is a carbonic anhydrase
inhibitor that increase excretion of
bicarbonate and potassium. Need to
monitor hypokalaemia.Typically seen in
edematous states (CHF, Cirrhosis,
nephrotic syndrome) following diuretic
therapy.
dose 250mg to 375 mg once or twice
daily. . effect can be monitored by
increase in urinary pH (>7).
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28. Treatment of R. acidosis
The goal is to increase the exhalation of CO2.
The treatments are :
I. Based on underlying cause.
II. By providing ventilation therapy.
III. IV administration of HCO3.
IV. Reversal of sedation or neuromuscular
relaxants.
V. Intubation and artificial ventilation, in severe
cases.
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30. Treatment of R. alkalosis
Correct the underlying disorder.
Slow the rate of breathing.
Administer of pain medication.
Breathe into paper bag helps raise of
CO2 level, person rebreathes CO2
back in after breathing out.
Hold the breath as long, as possible
and repeat the sequence 6 to 10
times.
31. Important consideration
about ABG sample
If possible, take an ABG sample at
room air.
Radial artery is preferred for colleting
the sample.
Prefer to use 22 gauge needle.
Avoid air bubbles.
Cool the sample immediately.
32. Potential sampling error-
Air contamination-spurious increase in
PO2.
Duration of exposure is more
important than volume of air bubbles.
Expel air immediately.
Discard the sample if froth present.
33. Venous sample- absence of flash of
blood on entry into vessel & absence
of autofilling of the syringe.
Timing of measurement-blood cell
consume 02 , produce C02 & lower
pH. magnitude of changes depends
on time.