The document summarizes research on functional materials based on metal complexes. Specifically, it discusses the coordination of organic ligands to lanthanide metals and the synthesis of Schiff base ligands. Lanthanide complexes have applications such as tumor detection and MRI contrast agents due to their luminescent properties. The research involves synthesizing Schiff base ligands, coordinating them to lanthanide ions, growing crystals via vapor diffusion, and determining crystal structures using X-ray crystallography. This allows studying the complexes for useful optical and magnetic properties.
Synthesis, Characterization and antimicrobial activity of some novel sulfacet...iosrjce
IOSR Journal of Applied Chemistry (IOSR-JAC) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of applied chemistry and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Chemical Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Growth, structural, optical, electrical and SHG studies of N-N′ allylthiourea...IJERA Editor
Potassium Dihydrogen Phosphate (KDP) crystals are one of the most popular crystals used for Non-linear
Optical (NLO) applications. Pure KDP single crystals and KDP crystals doped with N-N′ allylthiourea were
grown by the method of slow evaporation from aqueous solutions. The grown pure and doped crystals were
confirmed by X-ray single crystal and powder diffraction studies. The pure and doped crystals were
characterized by FTIR spectroscopy studies. Absorptions of these grown crystals were analyzed using UV–Vis–
NIR studies, and it was found that these crystals possess minimum absorption in the entire visible region.
Nonlinear optical studies of pure and doped crystals were carried out and it reveals that the dopants have
increased the efficiency of KDP crystals. Dielectric measurements were carried out along both the unique axis
and perpendicular directions at various temperatures ranging from 40 to 150 °C. The dielectric constant and the
dielectric loss values of N-N′ allylthiourea doped KDP crystals were lower than the pure KDP crystals. Also, it
indicates that 0.8 mole% N-N′ allylthiourea addition to KDP leads to low permittivity value dielectrics. The
results are discussed.
Synthesis, Characterization and antimicrobial activity of some novel sulfacet...iosrjce
IOSR Journal of Applied Chemistry (IOSR-JAC) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of applied chemistry and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Chemical Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Growth, structural, optical, electrical and SHG studies of N-N′ allylthiourea...IJERA Editor
Potassium Dihydrogen Phosphate (KDP) crystals are one of the most popular crystals used for Non-linear
Optical (NLO) applications. Pure KDP single crystals and KDP crystals doped with N-N′ allylthiourea were
grown by the method of slow evaporation from aqueous solutions. The grown pure and doped crystals were
confirmed by X-ray single crystal and powder diffraction studies. The pure and doped crystals were
characterized by FTIR spectroscopy studies. Absorptions of these grown crystals were analyzed using UV–Vis–
NIR studies, and it was found that these crystals possess minimum absorption in the entire visible region.
Nonlinear optical studies of pure and doped crystals were carried out and it reveals that the dopants have
increased the efficiency of KDP crystals. Dielectric measurements were carried out along both the unique axis
and perpendicular directions at various temperatures ranging from 40 to 150 °C. The dielectric constant and the
dielectric loss values of N-N′ allylthiourea doped KDP crystals were lower than the pure KDP crystals. Also, it
indicates that 0.8 mole% N-N′ allylthiourea addition to KDP leads to low permittivity value dielectrics. The
results are discussed.
degradation of pollution and photocatalysisPraveen Vaidya
The presentation deals with the use of conduction of photocatalytic reaction using the transition metal doped transparent semiconducting thinfilms. The precursor to film is prepared by the SILAR method, which is a chemical method.
International Journal of Engineering and Science Invention (IJESI)inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Chemo bio synthesis of silver nanoparticlesJagpreet Singh
Silver nanoparticles have a lot of ways of synthesis like physical and chemical
methods; some of these methods use a lot of chemical substances and are
very hazardous for humans and environment, so a novel, great, environmental
friendly, cheap and easy to use world of green chemistry has been used. A
number of characterization techniques such as UV-visible spectroscopy, Fourier
transformation infrared spectroscopy, X-ray diffraction study and scanning
electron microscopy revealed that silver nanoparticles have been used. Thus
the different response of the functional groups and the difference in the peaks
and UV-visible data was studied and then compared to understand and know
the way these different reducing agents react to the same starting material. The
green synthesis had a UV-visible peak at 446 nm while the one with chemical
synthesis had a peak at 395 nm. FTIR results of silver nanoparticles synthesis
by trisodium citrate (TSC) showed a peak at 1505 cm-1 which shows that the
compound has a stretching of the -C=C – bond. In another case, which was done
by using Sodium borohydride (NaBH4) a peak at 1695 cm-1 showed a –C=O- bond
indicating stretching and a weak absorption intensity. Another peak was present
which indicates a –O-H bond formation and presence which is a strong bond are
found to exist. A notable peak came for synthesis by orange peel at 1517 cm-1
which represents a –C=C- bond stretching as in aromatic compounds. Another
peak at 1732 cm-1 indicates the –C=O- bond. The XRD results on one of the
silver sample prepared by green methods showed silver nanomaterials formed
which had a average particle size of around 42 nm. FE-SEM results revealed that
silver nanomaterials were formed and had a flake like appearance in one of the
results. All the overall comparison showed that different modes of synthesis
of silver nanomaterials and different reducing agents give same materials but
with different peaks and intensities. All this data provided knowledge about the
fact that an alternative method can be used to create new nanoparticles if one
of the previously considered to tried method fails thus helping in extending the
broadways for research.
Photocatalytic degradation of some organic dyes under solar light irradiation...Iranian Chemical Society
Nanoparticles of the ZnO and TiO2 were synthesized and the physicochemical properties of the compounds were characterized by IR, X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The XRD patterns of the ZnO and TiO2 nanoparticles could be indexed to hexagonal and rutile phase, respectively. Aggregated nanoparticles of ZnO and TiO2 with spherical-like shapes were observed with particle diameter in the range of 80-100 nm. These nanoparticles were used for photocatalytic degradation of various dyes, Rhodamine B (RhB), Methylene blue (MB) and Acridine orange (AO) under solar light irradiation at room temperature. Effect of the amount of catalyst on the rate of photodegradation was investigated. In general, because ZnO is unstable, due to incongruous dissolution to yield Zn(OH)2 on the ZnO particle surfaces and thus leading to catalyst inactivation,the catalytic activity of the system for photodegradation of dyes decreased dramatically when TiO2 was replaced by ZnO.
Photosynthesis is an anabolic process by which simple inorganic substances like CO2 and H2O are converted into a complex substance like a carbohydrate in the presence of light and chlorophyll.
ABSTRACT
The use of Spirulina as a nutraceutical has been popularized owing to its high essential amino acid, vitamin, carotenoid, chlorophyll content, antioxidant and antiinflamatory properties. This organism can also bioaccumulate and biosorb essential and non essential heavy metals. These properties have been exploited in this study using the organism, Spirulina platensis ARM 728. The fortification of the biomass in different concentrations of Selenium (10 ppm, 40 ppm and 100 ppm) and Zinc (1 ppm, 5 ppm and 10 ppm) was carried out and an increased content of proteins, chlorophyll, carotenoids, SOD, CAT and total antioxidant activity was seen. The biosorption and desorption capacity of the organism for antimony at 80 ppm was also seen with fair results.
Keywords: antioxidant properties, bioaccumulation, biosorption, heavy metals, Spirulina fortification.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
degradation of pollution and photocatalysisPraveen Vaidya
The presentation deals with the use of conduction of photocatalytic reaction using the transition metal doped transparent semiconducting thinfilms. The precursor to film is prepared by the SILAR method, which is a chemical method.
International Journal of Engineering and Science Invention (IJESI)inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Chemo bio synthesis of silver nanoparticlesJagpreet Singh
Silver nanoparticles have a lot of ways of synthesis like physical and chemical
methods; some of these methods use a lot of chemical substances and are
very hazardous for humans and environment, so a novel, great, environmental
friendly, cheap and easy to use world of green chemistry has been used. A
number of characterization techniques such as UV-visible spectroscopy, Fourier
transformation infrared spectroscopy, X-ray diffraction study and scanning
electron microscopy revealed that silver nanoparticles have been used. Thus
the different response of the functional groups and the difference in the peaks
and UV-visible data was studied and then compared to understand and know
the way these different reducing agents react to the same starting material. The
green synthesis had a UV-visible peak at 446 nm while the one with chemical
synthesis had a peak at 395 nm. FTIR results of silver nanoparticles synthesis
by trisodium citrate (TSC) showed a peak at 1505 cm-1 which shows that the
compound has a stretching of the -C=C – bond. In another case, which was done
by using Sodium borohydride (NaBH4) a peak at 1695 cm-1 showed a –C=O- bond
indicating stretching and a weak absorption intensity. Another peak was present
which indicates a –O-H bond formation and presence which is a strong bond are
found to exist. A notable peak came for synthesis by orange peel at 1517 cm-1
which represents a –C=C- bond stretching as in aromatic compounds. Another
peak at 1732 cm-1 indicates the –C=O- bond. The XRD results on one of the
silver sample prepared by green methods showed silver nanomaterials formed
which had a average particle size of around 42 nm. FE-SEM results revealed that
silver nanomaterials were formed and had a flake like appearance in one of the
results. All the overall comparison showed that different modes of synthesis
of silver nanomaterials and different reducing agents give same materials but
with different peaks and intensities. All this data provided knowledge about the
fact that an alternative method can be used to create new nanoparticles if one
of the previously considered to tried method fails thus helping in extending the
broadways for research.
Photocatalytic degradation of some organic dyes under solar light irradiation...Iranian Chemical Society
Nanoparticles of the ZnO and TiO2 were synthesized and the physicochemical properties of the compounds were characterized by IR, X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The XRD patterns of the ZnO and TiO2 nanoparticles could be indexed to hexagonal and rutile phase, respectively. Aggregated nanoparticles of ZnO and TiO2 with spherical-like shapes were observed with particle diameter in the range of 80-100 nm. These nanoparticles were used for photocatalytic degradation of various dyes, Rhodamine B (RhB), Methylene blue (MB) and Acridine orange (AO) under solar light irradiation at room temperature. Effect of the amount of catalyst on the rate of photodegradation was investigated. In general, because ZnO is unstable, due to incongruous dissolution to yield Zn(OH)2 on the ZnO particle surfaces and thus leading to catalyst inactivation,the catalytic activity of the system for photodegradation of dyes decreased dramatically when TiO2 was replaced by ZnO.
Photosynthesis is an anabolic process by which simple inorganic substances like CO2 and H2O are converted into a complex substance like a carbohydrate in the presence of light and chlorophyll.
ABSTRACT
The use of Spirulina as a nutraceutical has been popularized owing to its high essential amino acid, vitamin, carotenoid, chlorophyll content, antioxidant and antiinflamatory properties. This organism can also bioaccumulate and biosorb essential and non essential heavy metals. These properties have been exploited in this study using the organism, Spirulina platensis ARM 728. The fortification of the biomass in different concentrations of Selenium (10 ppm, 40 ppm and 100 ppm) and Zinc (1 ppm, 5 ppm and 10 ppm) was carried out and an increased content of proteins, chlorophyll, carotenoids, SOD, CAT and total antioxidant activity was seen. The biosorption and desorption capacity of the organism for antimony at 80 ppm was also seen with fair results.
Keywords: antioxidant properties, bioaccumulation, biosorption, heavy metals, Spirulina fortification.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
In recent years, different types of inorganic nanoparticles (iNPs) with unique physicochemical properties have emerged.1−4 Among these, quantum dots (QDs) have proved to be very versatile,finding applications in electroluminescent displays, quantumcomputing, photovoltaics , solar cells,transistors,and biological imaging.For biological imaging applications, QDs are now excellent alternatives to organic chromophores.given that they can have similar sizes, shapes,and surface functional groups. A potentially prolific new direction in inorganic chemistry and nanochemistry could be to combine NPs with small metal complexes to seek synergistic and/or cooperative effects. In this context,combining QDs with coordination complexes is being explored as a new strategy to obtain cooperative systems with improved properties for applications in sensing, biological imaging, and molecular therapy. A prominent area of research in coordination chemistry is the development of metal complexes that can act as artificial nucleases. Overall, these synthetic DNA-cleaving reagents
Classification of dispersed systems & their general characteristics, size & shapes of colloidal particles, classification of colloids & comparative account of their general properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation, peptization& protective action.
A free radical is a molecule or molecular fragment that contains one or more unpaired electrons in its outermost orbital.
Free radical is generally represented by superscript dot.
One pot synthesis of cu(ii) 2,2′ bipyridyl complexes of 5-hydroxy-hydurilic acid
2016 URF Poster
1. Functional Materials Based on Metal Complexes
Presenters: Bailey Bouley, Colton D’Ambra, Huy Lam, Jason Ross
Research Educator: Dr. Lauren DePue
Faculty Professors: Dr. Richard Jones, and Dr. Bradley Holliday
3D-Structure
Funding and Support
Conclusion
Publications by the Functional Materials Stream
1) Chan, C.; Yang, X.; Jones, R. A; Holliday, B. J.; Stanley, J. M. “{μ-6,6’-Dimeth-Oxy-2,2'-[butane-1,4-Diylbis(nitrilo-Methyl-Idyne)]diphenolato-1:2κO,O,O,O:O,N,N',O}tris-(nitrato-
1κO,O')copper(II)gadolinium(III)” Acta Crystallogr. Sect. E. Struct. Rep. 2010, 66, m576–7.
2) Liao, A.; Yang, X.; Stanley, J. M.; Jones, R. A.; Holliday, B. J. “Synthesis and Crystal Structure of a New Heterotrinuclear Schiff-Base Zn–Gd Complex.” J. Chem. Crystallogr. 2010, 40, 1060–1064.
3) Stanley, J. M.; Chan, C. K.; Yang, X.; Jones, R. A.; Holliday, B. J. “Synthesis, X-Ray Crystal Structure and Photophysical Properties of tris(dibenzoylmethanido)(1,10-phenanthroline)samarium(III).”
Polyhedron 2010, 29, 2511–2515.
4) Yang, X.; Chan, C.; Lam, D.; Schipper, D.; Stanley, J. M.; Chen, X.; Jones, R. A; Holliday, B. J.; Wong, W.-K.; Chen, S. “Anion-Dependent Construction of Two Hexanuclear 3d-4f Complexes with a
Flexible Schiff Base Ligand”. Dalton Trans. 2012, 41, 11449–11453.
5) Yang, X.; Lam, D.; Chan, C.; Stanley, J. M.; Jones, R. A; Holliday, B. J.; Wong, W.-K. “Construction of 1-D 4f and 3d-4f Coordination Polymers with Flexible Schiff Base Ligands.” Dalton Trans.
2011, 40, 9795–9801.
6) Yang, X.; Schipper, D.; Jones, R. A; Lytwak, L. A; Holliday, B. J.; Huang, S. “Anion-Dependent Self-Assembly of near-Infrared Luminescent 24- and 32-Metal Cd-Ln Complexes with Drum-like
Architectures.” J. Am. Chem. Soc. 2013, 135, 8468–8471.
7) Yang, X.; Schipper, D.; Liao, A.; Stanley, J. M.; Jones, R. A.; Holliday, B. J. “Anion Dependent Self-Assembly of Luminescent Zn–Ln (Eu and Tb) Salen Complexes.” Polyhedron 2013, 52, 165–169.
8) Yang, X.; Schipper, D.; Zhang, L.; Yang, K.; Huang, S.; Jiang, J.; Su, C.; Jones, R. A. “Anion dependent self-assembly of 56-metal Cd–Ln nanoclusters with enhanced near-infrared luminescence
properties.” Nanoscale. 2014, 6, 10569.
9) Jones, R. A.; Gnanam, A. J.; Arambula, J. F.; Jones, J. N.; Swaminathan, J.; Yang, X.; Schipper, D.; Hall, J. W.; DePue, L. J.; Dieye, Y.; et al. “Lanthanide nano-drums: a new class of molecular
nanoparticles for potential biomedical applications.” Faraday Discuss. 2014, 175, 241–255.
10) Brown, K. A.; Yang, X.; Schipper, D.; Hall, J. W.; DePue, L. J.; Gnanam, A. J.; Arambula, J. F.; Jones, J. N.; Swaminathan, J.; Dieye, Y.; et al. “A self-assembling lanthanide molecular nanoparticle for
optical imaging.” Dalt. Trans. 2015, 44 (6), 2667–2675.”
X-ray Crystallography
Coordination of Ligands to Lanthanides
Synthesis of Schiff Base Ligands
Introduction to our Research
The coordination of a ligand to a lanthanide begins by selecting the appropriate reagents for the desired result. Using Hard/Soft
Acid/Base Theory it is established that lanthanides bind well to ligands containing oxygen and nitrogen. Most of the lanthanide
metals luminesce at specific wavelengths in either the visible or near-infrared region. Others have different applications, such as
gadolinium whose magnetic properties allow it to act as a contrast agent during an MRI scan. Selecting the appropriate ligand
depends on the functional groups as well. Most ligands used have derivatives with an added bromine that can substitute other
functional groups. The ligand chosen also affects the crystal structure, so the ligand can be chosen based on a desired structure.
General Procedure:
1. Dissolve lanthanide salt in desired solvents.
2. Add ligand to the solution.
3. Reflux ligand for 45-60 minutes.
4. Allow solution to cool.
5. Filter solution to remove solid impurities.
6. Pipette solution into test tubes.
7. Put test tubes in a jar filled with diethyl ether.
8. Using Slow Vapor Diffusion, wait until formation of crystals.
The typical solvents used are ethanol and toluene because the complexes are soluble in ethanol, but not toluene, so this reduces the
overall solubility, promoting crystallization. The general procedure can be modified for different ligands based on what has worked
in the past. For example, letting the solution sit for a couple of days before filtering sometimes causes complexes to crystallize
directly in the round bottom flask. Additional reagents can be added to the reaction flask to attempt the formation of a multi-nuclear
coordination compound.
The jars create an environment that allows slow vapor diffusion to form crystals. The highly volatile diethyl ether slowly diffuses
into the test tubes mixing together and forming a new solution. The complexes are insoluble with diethyl ether, so they will be
supersaturated in the solution after the diethyl ether enters. If the complex can find a nucleation site in the test tube (i.e. a
microscopic scratch on the side), crystallization will begin. If there are no nucleation sites, the complex will precipitate out. The
diethyl ether enters the test tubes slowly allowing for the crystals to form in high enough quality to allow their structure to be found
via X-ray crystallography.
Figure 4. Lanthanide metals luminesce at specific wavelengths in narrow bands
primarily in the visible or NIR spectrum. The specific wavelength allows the
lanthanide metals to be found when they attach to something, creating uses in fields
such as cancer diagnosis.
Figure 7. Reaction set-up for typical synthesis.
Figure 2. Luminescent lanthanide containing
compounds under UV lamp (Sm – pink; Tb – green;
Eu – red).
Figure 3a & 3b. Growing
crystals via slow vapor
diffusion.
Ligand
Synthesis
Lanthanide
Coordination
Crystal Growth
X-ray
Crystallography
Group
Imine synthesis begins by combining the amine and aldehyde components in a round bottom flask
containing ethanol as a solvent. The solutions are refluxed on medium heat and high stir for 1-2
hours to ensure progression of the reactions. After the refluxes are complete, the solutions were
left to cool to room temperature to promote precipitation.
Figure 6. Sample vanillin derivatives used as aldehydes and sample amines used in synthesizing Schiff base ligands.
Figure 8. Synthesis of bidentate and monodentate Schiff-based ligands from vanillin
derivatives and amines.
Single crystal X-ray diffraction is a valuable tool in determining the structures of complexes synthesized in the
functional materials lab. As the name implies, a single crystal is required for analysis and must be free of cracks,
twinning, and other deformities. After initial screening under a microscope with polarized light, a single crystal may be
mounted onto a loop for diffraction.
Once the crystal is mounted and centered a beam of X-rays is directed at the center of the crystal. This initial beam is used to
determine if the crystal is of sufficient quality to continue diffraction. If the crystal is acceptable, the diffraction continues and
data is collected as the crystal is rotated on its loop. Depending on the specific machine being used, an initial crude structure is
given and the software Olex2 is then used to refine the structure in preparation for publication.
Figure 5. Crystal structure of the complex that results from the
coordination of a lanthanide metal to the Schiff base ligand composed
of o-vanillin and o-phenyldiamine. The oxygen atoms of the ligand
donate their electron pairs to make a bond coordinate bond with the
ligand.
If a significant amount of the ligand formed a solid, the solution
was filtered via vacuum filtration and the imine collected. For many
of the monodentate ligands however, they are liquids at room
temperature and had to be stored as either a molar solution in
ethanol or as a pure liquid. Some ligands that were solid at room
temperature but soluble in ethanol and were rotary evaporated to
remove the ethanol to recover the imine.
After the products were isolated, NMR samples were run to show the absence of the aldehyde and
amine peaks and the presence of the imine peaks, indicating the success of the reaction.
Figure 1. The lanthanide luminesces through the antenna effect. Light
is absorbed by the ligand and transfers energy to the lanthanide, causing
it to enter an excited state. The lanthanide then relaxes and releases
light through luminescence.
Lanthanide complexes have many applications due to their spectroscopic, magnetic and luminescent properties.
These applications include: (1) detecting tumors under a UV light and observing whether the area contains a
luminescent lanthanide; (2) multiple variations of Gd(III) chelates are used in MRI as contrasting agents; (3) and
lanthanides are prevelant in OLED television displays due to these sharp, strong lanthanide emissions. These
luminescent properties would not be possible without the use of organic ligands on lanthanide ions to provide stability
and utilize the Antennae Effect.
The organic ligands absorb UV light and transfer the energy to
lanthanide ion. Once the lanthanide ion is excited by the ligand,
it releases the energy in a narrow light emission that depends on
the lanthanide ion in the complex. The experiments conducted
used organic Schiff base salen-type ligands with lanthanide
ions, transition metal ions, or both to make interesting metal
complexes. Single crystal X-ray crystallography determines the
structure of the complexes, which can then be further studied
for other useful properties.
Figure 9. Examples of the crystal structures that results from the ligand reacted in certain conditions: (a) The pictured
ligand reacted with Nd(NO3)3 to form a neodymium compound containing two ligands bound via the oxygens; (b) The
pictured ligand reacted with Cd(OAc)2 and Nd(OAc)3 to form a barrel-shaped structure containing 12 ligands and 8
neodymium atoms.
Figure 10. X-ray quality crystals are removed from test tubes and collected in oil to prevent the solvent from drying out.
They’re then placed on a loop in preparation for X-ray diffractometry. Once the X-ray diffraction data is collected, the
structure can usually be deciphered.
Further research will consist primarily of synthesizing more ligands and metal complexes. Additional characterization of the
metal complexes will be done involving fluorimetry, IR spectroscopy, and NMR spectroscopy. Fluorimetry of the metal
complexes will determine the quantum yield. Knowledge of this helps determine if the complexes will be good candidates for
applications utilizing their luminescence.
Some of the ligands synthesized will contain a bromine functional group which will allow a number of substitutions to occur in
order to functionalize the complex. Once substituted, the metal complexes can find potential uses as contrast reagents, NMR
shift reagents, or as biomarkers. The ring structure shown in Figure 10 shows promise as a biomarker due to the high number of
lanthanide metals and lack of toxic cadmium as in the barrel structures. The high number of lanthanides increases the chances of
the lanthanide centers reaching the targeted area as well as causing the targeted area to luminesce brighter once subjected to UV
light.
Figure 11. Example of MRI taken without contrast
agent (left) and with a Gd complex as a contrast
agent (right).
Figure 12. Example of the effect of a Eu NMR shift reagent on n-pentanol. The
overlapping peaks shown in (a) are separated enough to be distinguished in (b).