International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
The complexation of metals with ligands can drastically change the physico–chemical and biological properties of the metal species. The large number of ionizable sites in the ligand molecule, mainly phenolic and carboxylic groups, provide the appreciable ability to form stable complexes and chelates with heavy metal cations (Pb(II), Cu(II), Zn(II) and Cd(II)). In this paper We would like to review the transition metal complexes of salicylic acid.
The complexation of metals with ligands can drastically change the physico–chemical and biological properties of the metal species. The large number of ionizable sites in the ligand molecule, mainly phenolic and carboxylic groups, provide the appreciable ability to form stable complexes and chelates with heavy metal cations (Pb(II), Cu(II), Zn(II) and Cd(II)). In this paper We would like to review the transition metal complexes of salicylic acid.
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International Journal of Engineering and Science Invention (IJESI)inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Effect of Water And Ethyl Alcohol Mixed Solvent System on the Stability of Be...IJERDJOURNAL
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But if the paracetamol was bidentate, it is coordinated by atoms (O-carbonyl and N-amide), (O-hydroxyl and
N-amide) or (O-carbonyl and O-hydroxyl). The authors also found that free paracetamol and its complexes
have antimicrobial activity.
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International Journal of Engineering and Science Invention (IJESI)
1. International Journal of Engineering Science Invention
ISSN (Online): 2319 – 6734, ISSN (Print): 2319 – 6726
www.ijesi.org Volume 2 Issue 7 ǁ July. 2013 ǁ PP.20-24
www.ijesi.org 20 | Page
Coordination Chemistry of Orotic acid
1,
Ch.V.Padmarao, 2,
K.Praveen , 3,
B.Kishore Babu*4,
K.Rajkumar,5,
K.Mohanarao ,
6,
J.Nagasirisha , 7,
B.Venkateswara Rao , 8,
G.Susheelabai, 9,
K.Raghu Babu,
10,
K.Vijaya Raju
Department of Engineering Chemistry,AUCE(A), Andhra University,Visakhapatnam
ABSTRACT: Our research group have been working on transistion metal complexes and their activity in the
biology field, especially antimicrobial and anticancer properties. Novel pseudohalide ligands with orotic acid
and its metal salt Ni(II) have been synthesized1
and evaluated for their antimicrobial activities by disc diffusion
method. The complexes have been characterized by IR, SEM, Raman, P-Xrd and UV-Visible spectroscopic
techniques.TheDiaquabis(imidazole)orotatoNickel(II),[Ni(HOr)(H2O)2(Imd)2](1),Diazidobis(orotato)nickel(II)],
[Ni(HOr)2(N3)2](2),Diisocyanatobis(orotato)nickel(II)],[Ni(HOr)2(NCO)2]andDithiocyanatobis(orotato)nickel(I
I)],[Ni(HOr)2(NCS)2] have been synthesized1
and characterized by means of elemental analysis, IR, UV–Vis
studies. The Ni(II) ions in [M(C5H2N2O4)(H2O)2(C3H4N2)2] the complex has a distorted octahedral coordination
geometry comprised of one deprotonated pyrimidine N atom and the adjacent carboxylate O atom of the orotate
ligand, two tertiary imidazole N atoms and two aqua ligands.
KEYWORDS: Antimicrobial activity, Complex, Ligand, Orotic acid.
I. IMPORTANCE OF OROTIC ACID
Orotic acid (Vitamin B13, uracil carboxylic acid) plays a key role in the biosynthesis of pyrimidine
bases of nucleic acids 2
. Some metal compounds of the acid itself and derivatives have successful applications in
curing syndromes related with metal ion deficiencies3
and promising applications as therapeutic agents for
cancer 4
.
N
H
O
HN
O
O
OH
FIG 1 : OROTIC ACID
II. RELATED LITERATURE WORK
The Biocoordination-Chemistry:
The biocoordination chemistry of vitamin B13 therefore demands a better understanding regarding its
interactions with metal ions. The orotic acid molecule (H3Or) has a multidentate nature . The most potential
coordination sites in the pH range of 3 to 9 are the carboxylic oxygen and the adjacent pyrimidine nitrogen atom
(N1), for the formation of a stable chelate ring. In very alkaline solutions, deprotonation occurs from (N1) and
coordination through the other sites becomes available as well due to the existence of different tautomeric forms
5-7
and the references therein. The literature lists several reports on mononuclear and polynuclear orotato
complexes.
Bioconversion reactions of orotic acid occur in the presence of enzymes. Their activation and normal
functioning require metal ions. For this reason a number of papers devoted to the interaction of metal ions with
orotic acid and its derivatives have appeared in publications.8,9
Attention has been devoted mainly to the
interrelation between the chemistry of the metal ions and their role in the life of organisms.
It also exhibits bacteriostatic and cytostatic properties. Besides the biological relevance, the orotic acid
and its anions H2Or2, HOr22 and Or32 are interesting multidentate ligands as they can coordinate through the two
pyrimidine nitrogen atoms, the two carbonyl oxygens and the, oxygens from the carboxyl group. The
equilibrium composition of the reactant mixture and thus the solution pH are critical factors which determine the
mode of coordination. Between pH 3 and 9, orotic acid exists mainly as readily-coordinating monodeprotonated
2. Coordination Chemistry of Orotic Acid
www.ijesi.org 21 | Page
H2Or2. It is preferred in ketonic form at low and neutral pH so it coordinates monoanionic from the –COOH
group. At higher pH values, enolic form is preferred and makes the deprotonated heterocyclic ring N atoms
avaliable for bidentate coordination 10
. The tautomerism between the ketonic and enolic forms allows
multifaceted coordinations 11
and thus makes the acid an interesting ligand.
Recent interest has focused on the proposed biological carrier function of orotic acid and the
corresponding anionic species for metal ions, which is held responsible for the obviously successful application
of metal orotates in curing syndromes associated with a deficiency of a variety of metals such as calcium,
magnesium, zinc or iron 12,13
. In the literature review we have mentioned calcium and magnesium
structural,spectral and biological chemistry of orotato metal complexes.
So far many complexes containing orotate anions have been prepared and structurally
studied14,15,16,17,18-28
. In previous works, others have prepared and structurally characterized a series of cobalt(II),
nickel(II), copper(II) and zinc(II) complexes containing the orotate anion and 2-methylimidazole ligand 29
. We
have been preparing similar complexes but the ligands are different.We have chosen bridging ligands ,
psuedohalides for our thesis work.
III. PROMISING LIGAND (H3Or) CHEMISTRY WITH METALS
Transition metal complexes of orotic acid and its mixed ligand derivatives continue to attract attention
because of orotic acid’s multidentate functionality and its considerable role in bioinorganic chemistry 30.
Metal
orotates are also widely applied in medicine 31
. In addition, platinum, palladium and nickel orotates with wide
variety of substituents have been screened as therapeutic agents for cancer 32
as we mentioned in the introduction
chapter. Furthermore, zinc(II) and cobalt(II) orotate complexes have shown antimicrobial activity 33
. Orotic
acid, besides being biologically important, is also an interesting organic building block in coordination
chemistry 34-36
. The deprotonated orotates are a widely used ligand for the construction of coordination
compounds due to their versatile bridging modes, such as monodentate, bidentate, tridentate bridging and mixed
chelating bridging35-44,45
. Great interest has been focused on design and syntheses of novel metal-organic hybrid
coordination compounds in recent decades,of which multi nuclear clusters show unique catalysis and
magnetism46,47
and polymeric complexes can afford the intriguing topological network as well as many potential
applications in many areas such as optical,seperation and gas storage 48-50
. One of the key challenges in
purposeful construction of the new hybrid frameworks depends particularly on appropriate organic ligands or
building blocks,of which the cluster cores and multidentate bridging ligands are fine candidates in most cases51
.
In addition to a unique role in bio inorganic and pharmaceuticalchemistry 52
, On the other hand, it contains
potentially hydrogen-bond acceptor and hydrogendonor, and can play disply differently hydrogen-bonding
interactions in supra molecular systems53
. In terms of coordination manners, oroticacid exhibits inter- esting
behaviors, in which it employs its carbonyl oxygen or nitrogen atom to links metal ions and the carboxylate
oxygen atoms remain free 54,55
. In terms of valences,oroticacid can act as mono or bi-valence anions to connect
metal cations in general, as well as a neutral free ligand to locate in the lattices of the supramolecules
sometimes 54
.
The literature lists many reports on the coordinating preferences of the orotate moiety in metal
complexes. It was found that in solutions with neutral or slightly acidic pH, Cu(II), Zn(II), Co(II), Mn(II),
Fe(III), Cr(III), VO(II), Cd(II), Hg(II) and Ag(I) are coordinated through the carboxylate group, while Ni(II),
Co(II) and Cu(II) are coordinated through the carboxylate end and the adjacent N1 56-60
. Bidentate binding
through N1 and the carboxylate group was observed by several crystal structure determinations 61-65
. In the
complexes [Co(HOr)(OH)(H2O)(NH3)]n and [Ni(HOr)(OH)(H2O)2(NH3)]n the orotate anion bridges the metal
ions through the carboxylate and the N1 and O2 atoms, forming one-dimensional polymeric chains 66
. A recent
reinvestigation of nickel(II) orotate pentahydrate [Ni(HOr)(H2O)4]·H2O by modern diffraction, spectroscopic
and theoretical methods revealed novel structural features 67
. In the present study, we have synthesized and
characterized the analogous hexahydrate salt of nickel(II).
The crystal structures of mononuclear Ni 68,69
, Mg 70
, Co 71
, Zn 72
complexes have been described
where orotate dianions (HOr)2K act as bidentate ligands. In polymeric complexes, (HOr)2K acts as a
polydentate ligand and bridges the metal ions forming 1D-polymeric chains with Ca 73
, Cd74
, Mn, Cu 75
, Ni 76,77
or 2D-layer structures in mixed metal complexes where the layers are interconnected with hydrogen bonds to
form the final network structures 78
. Relatively little information is available regarding the compounds with
orotate monoanion,(H2Or)1K. Crystal studies with Mg 79
, Zn 80
and Ni 81
have showed that aquated metal
cations interact with the (H2Or)1K counter ions through hydrogen bonds. In these isotopic compounds, the
orotate monoanion does not enter the inner coordination sphere of the metal.
3. Coordination Chemistry of Orotic Acid
www.ijesi.org 22 | Page
Magnesium orotate complexes:
Both vitamin B13 and magnesium orotate have beneficial effects in prophylaxis and treatment of heart
diseases 82
. Moreover, complexes of orotic acid and diaminocyclohexane ligands (DACH) with platinum(II) and
palladium(II) ions have been investigated as potential anticancer agents 83
.
Calcium orotate complexes :
An orientation is given concerning the clinical effects of calcium orotate (called Ca orotate for short).
Because calcium orotate is free from side effects, It is superior to conventional calcium salts, which have certain
problems when applied in osteoporosis with concomitant arteriosclerosis of the abdominal aorta. Calcium
orotate, an the other hand, protects the body from arteriosclerosis. Calcium, for this reason, is of value as a food
supplement when used in the form of calcium orotate, which can penetrate the cell membranes as a complex
form, compensating for defective calcium transit into the cells. In addition, calcium orotate has a special affinity
for cartilage and other bradtrophic tissue, where it is metabolized.
Not only is the basic principle of action quite simple, but the long time therapeutic effects are of
considerable interest. A new dimension of therapy now appears with the improvements in osteochondrosis and
disk degeneration treatment. Far better than the present therapeutic possibilities. Much the same observations
seem to apply to osteoporosis. Parallel investigations point to the important pathogenetic significance of a
defective calcium transport through the cell membrane. This is the case, for example, in hypertensions--
especially essential hypertension--in fatty liver, in disturbances of the ductile of the heart, and in contractile and
metabolic insufficiency of the hypertrophic myocardium. In respect to all of these indications, calcium seems to
bring about the most promising therapeutic results, when combined with the carrier orotic acid for better
transmembrane transport, in the form of calcium orotate.
Lead orotate complexes :
There has been a resurgence of interest in the coordination chemistry of lead(II) in recent years, not
only owing to their biological activities 84
, but also because lead(II) possesses a large radius, a variable
stereochemical activity, and a flexible coordination environment, which provides unique opportunities for the
construction of novel network of topologies 85
. There are two kinds of classifications in lead(II) complexes,
holodirected and hemidirected configurations depending on mainly the coordination number 85c, 86
. It is showing
luminiscent property.
IV. CONCLUSIONS
This review mainly focus on complexes of orotic acid with different metals and their spectroscopical
studies and biological importance in various human diseases.The bioactivity of these synthesized compounds is
a complex phenomenon related to different factors and the metal complexes are more active than the free
ligands. These active compounds may serve as a starting point for further studies on metal complexes acting as
drugs.
V. ACKNOWLEDGMENTS
BKB acknowledges grants from the Ref No: 42-354/2013 UGC (INDIA), New Delhi . KP and CHP is
grateful to UGC (INDIA) for providing the fellowship grants. We are grateful for the technical assistance
provided by the Department of Engineering Chemistry at the andhra University ,visakhapatnam (INDIA) and
the University of Hyderabad for providing the spectral data.
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