An antiviral that is a nucleotide analog would have an antiviral mode of action that blocks maturation. blocks penetration. inhibits DNA synthesis. blocks transcription and translation. Solution ANSWER: C. Inhibits DNA synthesis Some anti-viral drugs which are nucleoside analogues lacks free 3\' groups for the addition of another nucleotide so when it is added to the growing chain, it stops synthesis. some are involved in inactivating the viral DNA Polymerase.