Hexokinase A. Catalyzes the conversion of glucose 6-phosphate into fructose 1,6 bisphosphate B. Requires Ca^+2 for activity C. Uses pyrophosphate to form glucose 6-phosphate D. Catalyzes the transfer of a phosphate group to variety of hexose sugars E. Catalyzes a phosphoryl shift reaction Solution The answer is: D. catalyzes the transfer of a phosphate group to a variety of hexose sugar. Hexokinase can phosphorylate sugars like glucose, mannose etc..