This document discusses the need for radically open-minded leadership in times of uncertainty and change. It recommends that leaders stop focusing on the past and current problems, and instead develop their organization's capabilities for the future. Specifically, the document recommends that leaders: 1) identify potential future challenges, 2) prepare their organization's capabilities and capacities for the future, 3) start experimenting with new practices, and 4) learn from failures and successes to continually improve. Radically open-minded leaders can inspire transformation by providing a vision of opportunities rather than threats and focusing on "next practices" rather than past successes. They understand that fields of expertise are converging in the changing world.