Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...
Primary pulmonary neuroendocrine tumors
1.
2. INTRODUCTION
NETs – heterogenous group of malignancies arising from NEC throughout
the body, m/c lungs, SI, rectum
Broncho-pulmonary carcinoids : 25% of all carcinoid tumors
1 - 2% primary lung tumors in adults
M/c primary lung tumor in children
Editor's Notes
F>M
Compared to bronchogenic Ca incidence more frequent in younger, less smoking history
The neuroendocrine cell system is divided into cell types that form glands (ie, adenohypophysis, parathyroid, etc.)
and diffusely distributed cell types….
diffuse neuroendocrine system (DNES)
Gustaffson & colleagues – DIPNECH
TC gross pathologic examination
Every 3 years…as incidence is much higher than previously believed
2015 WHO update …..
high-grade lung NETs (>40%) and carcinoids (<20%)….particularly in crushed biopsies in which carcinoids maybe mistaken for SCLC
SRS to localize & METS
FDG-PET…chong et al SUV in TC 3.2-3.4
AC – Suv 4-7
Sleeve resection if ….. Negative margins can be obtained, remaining lung healthy
Everolimus – mTOR receptor inhibitor
PRRT may be used to treat metastases of TC
and AC, with currently 90 Yttrium-DOTA Octreotide
Antiangiogenesis – sunitinib, …tyrosine kinase inhibitor
Bevacizumab….mab for VEGF
Antiangiogenesis – sunitinib, …tyrosine kinase inhibitor
Bevacizumab….mab for VEGF
Antiangiogenesis – sunitinib, …tyrosine kinase inhibitor
Bevacizumab….mab for VEGF
