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INTRODUCTION
 NETs – heterogenous group of malignancies arising from NEC throughout
the body, m/c lungs, SI, rectum
 Broncho-pulmonary carcinoids : 25% of all carcinoid tumors
 1 - 2% primary lung tumors in adults
 M/c primary lung tumor in children
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors
Primary pulmonary neuroendocrine tumors

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Primary pulmonary neuroendocrine tumors

  • 1.
  • 2. INTRODUCTION  NETs – heterogenous group of malignancies arising from NEC throughout the body, m/c lungs, SI, rectum  Broncho-pulmonary carcinoids : 25% of all carcinoid tumors  1 - 2% primary lung tumors in adults  M/c primary lung tumor in children

Editor's Notes

  1. F>M Compared to bronchogenic Ca incidence more frequent in younger, less smoking history
  2. The neuroendocrine cell system is divided into cell types that form glands (ie, adenohypophysis, parathyroid, etc.) and diffusely distributed cell types…. diffuse neuroendocrine system (DNES)
  3. Gustaffson & colleagues – DIPNECH
  4. TC gross pathologic examination
  5. Every 3 years…as incidence is much higher than previously believed
  6. 2015 WHO update …..
  7. high-grade lung NETs (>40%) and carcinoids (<20%)….particularly in crushed biopsies in which carcinoids maybe mistaken for SCLC
  8. SRS to localize & METS FDG-PET…chong et al SUV in TC 3.2-3.4 AC – Suv 4-7
  9. Sleeve resection if ….. Negative margins can be obtained, remaining lung healthy
  10. Everolimus – mTOR receptor inhibitor PRRT may be used to treat metastases of TC and AC, with currently 90 Yttrium-DOTA Octreotide
  11. Antiangiogenesis – sunitinib, …tyrosine kinase inhibitor Bevacizumab….mab for VEGF
  12. Antiangiogenesis – sunitinib, …tyrosine kinase inhibitor Bevacizumab….mab for VEGF
  13. Antiangiogenesis – sunitinib, …tyrosine kinase inhibitor Bevacizumab….mab for VEGF