What is the difference between Information System and Information Technology? What is the difference between Information System and Information Technology? Solution Information System is all about the machines which hold the data/information, where as information technology is not limited to the systems, but is extended to the I/O devices, and networking devices that will keep the systems together, and the networking peripherals, the technology used to keep the machines, and the information in the machines secure, something like Database Management Systems, firewalls, etc all together will form the Information Technology. Simply speaking the set of tangible machines will form the Information Systems, where are the combination of all the things together including the tangible and intangible things will form the information technology. .