Revision with a Master Quiz of 34 questions based on NEET PG Sample Questions on Mumps from Previous Year NEET PG Online Exams.

1. A middle aged man with a long history of sexual activity slowly develops testicular
enlargement. Needle biopsy demonstrates the presence of obliterative endarteritis with
perivascular cuffing of lymphocytes and plasma cells. A diffuse interstitial inflammation
with edema and prominent plasma cell infiltrate is also present. Which of the following is
the most likely diagnosis?
A: Gonorrhea
B:
Mump
s
C: Nonspecific orchitis
D: Syphilis
Correct Ans:D
Explanation
This is one presentation of syphilis, which can involve the testis and epididymis in both the
acquired and congenital types of the disease. Characteristically, the testis is usually
involved before the epididymis. Microscopically, the testis may show either gumma
formation or the findings described in the question stem.Gonorrhea usually causes an acute
epididymitis and orchitis with prominent neutrophils.
Mumps orchitis would usually be accompanied by parotitis.
Nonspecific orchitis is characterized by prominent neutrophils.
Ref: Brooks G.F. (2013). Chapter 24. Spirochetes and Other Spiral Microorganisms. In G.F.
Brooks (Ed), Jawetz, Melnick, & Adelberg's Medical Microbiology, 26e.
The presence of Negri inclusion bodies in host cells is characteristic of?
A: Mumps
B: Infectious mononucleosis
C: Rabies
D: Congenital rubella
Correct Ans:C
Explanation

2. The definitive diagnosis of rabies in humans is based on the finding of Negri
bodies, which are cytoplasmic inclusions in the nerve cells of the spinal cord and
brain, especially in thehippocampus. Negri bodies are eosinophilic and generally
spherical in shape; several may appear in a given cell. Negri bodies, although
pathognomonic forrabies, are not found in all cases of the disease.
Also Know:
The rabies virus is a bullet-shaped, enveloped, RNA virus, 180 by 70 nm, of the
Lyssavirus genus within the Rhabdovirus family.
Ref:Ray C.G., Ryan K.J. (2010). Chapter 17. Rabies. In C.G. Ray, K.J. Ryan
(Eds),Sherris Medical Microbiology, 5e
All are TRUE about respiratory viruses, EXCEPT:
A: RSV - common cause of bronchiolitis in infants
B:
Mumps causes septic
meningitis
C: SSPE is a late complication of measles
D: Parainfluenza attaches to cell by hemagglutinin
Correct Ans:B
Explanation
In children and young adults, enteroviruses are the cause of up to 90% of cases of
aseptic meningitis in which an etiologic agent can be identified. Bacterias cause
septic meningitis.
Respiratory syncytial virus is the most important cause of (bronchiolitis) lower
respiratory tract illness in infants and young children.
SSPE, the rare late complication of measles infection, occurs with an incidence of
about 1:300,000 cases. The disease begins insidiously 5–15 years after a case of
measles; it is characterized by progressive mental deterioration, involuntary
movements, muscular rigidity, and coma. It is usually fatal within 1–3 years after
onset. Patients with SSPE exhibit high titers of measles antibody in cerebrospinal
fluid and serum and defective measles virus in brain cells. With the widespread
use of measles vaccine, SSPE has become less common.

3. Parainfluenza viruses are ubiquitous and cause common respiratory illness in
persons of all ages. They are major pathogens of severe respiratory tract disease
in infants and young children. Only RSV causes more cases of serious
respiratory disease in children. They attach via haemagglutinin to sialic acid
containing receptors on the cell surface of respiratory epithelium.
Ref: Brooks G.F., Carroll K.C., Butel J.S., Morse S.A., Mietzneron T.A. (2010).
Chapter 40. Paramyxoviruses & Rubella Virus. In G.F. Brooks, K.C. Carroll,
J.S. Butel, S.A. Morse, T.A. Mietzneron (Eds), Jawetz, Melnick, & Adelberg's
Medical Microbiology, 25e.
An 8 year old boy is taken to a pediatrician because of behavioral changes, mild
intellectual deterioration, and "laziness." Over the next several months the boy
develops increasing clumsiness and periodic, involuntary, jerky movements every
3 to 6 seconds. Visual deterioration is apparent upon visual field testing, and
optic atrophy is evident on funduscopic examination. Cerebrospinal fluid studies
do not show significant pleocytosis, but oligoclonal bands of IgG are present on
CSF electrophoresis. The electroencephalogram shows periodic discharges that
are synchronous with the periods of myoclonus. Computed tomography (CT) of
the head shows low-density white matter lesions and cerebral atrophy. At the age
of 10, the boy dies. Prior infection with which of the following agents was
probably related to the patient's condition?
A: Measles virus
B:
Mumps
virus
C: Papillomavirus
D: Poliovirus
Correct Ans:A
Explanation
The rare disease illustrated is subacute sclerosing panencephalitis (SSPE), which
typically presents as in the question stem. SSPE appears to be due to a
combination of persistent, possibly abnormal measles virus and to autoimmune
damage caused by antibodies directed against the virus. Many patients
developing SSPE have had measles at 2 years of age or younger; there is typically
a six-year interval between measles infection and symptom development. A small
proportion of cases have followed vaccination with live measles virus.
Unfortunately, no effective therapy has been developed, although some

4. experimental work with drugs such as isoprinosine shows some promise.
Postinfectious encephalomyelitis, rather than SSPE, can follow mumps or
varicella. Latent infection with the varicella virus causes shingles (herpes zoster).
Papillomaviruses are associated with warts. They do not usually infect the
brain. Poliovirus causes gastrointestinal disturbances, viremia, and paralysis.
Ref: Ray C.G., Ryan K.J. (2010). Chapter 10. Mumps Virus, Measles, Rubella,
and Other Childhood Exanthems. In C.G. Ray, K.J. Ryan (Eds), Sherris Medical
Microbiology, 5e.
Which of the following type of virus is known as Lymphoproliferative virus?
A: Adenovirus
B:
Hepatitis
A
C: Mumps
D: EB virus
Correct Ans:D
Explanation
EBV is known to cause lymphoproliferative disease especially in patients with
primary or secondary immunodeficiency. The incidence of these lymphomas is
1% to 2% after renal transplantations and 5% to 9% after heart–lung
transplantations. Most of the patients presents with persistent fever,
lymphadenopathy, and hepatosplenomegaly.
EBV is known to cause infectious mononucleosis, burkitt's lymphoma,
nasopharyngeal carcinoma, and in AIDS patients its known to cause hairy
leukoplakia of tongue, interstitial lymphocytic pneumonia and lymphoma.
In Sub saharan africa Burkitt lymphoma is the most common malignancy in
young children. It is thought to result from an early EBV infection that produces
a large pool of infected B lymphocytes. It can be diagnosed by presence of
increased IgA antibody levels to both VCA and early EBV antigens.
Nasopharyngeal carcinoma is endemic in Southern China, where it is responsible
for 25% of mortality from cancer.

5. Ref: Ray C.G., Ryan K.J. (2010). Chapter 14. Herpesviruses. In C.G. Ray, K.J.
Ryan (Eds), Sherris Medical Microbiology, 5e. Ray C.G., Ryan K.J. (2010).
Chapter 14. Herpesviruses. In C.G. Ray, K.J. Ryan (Eds), Sherris Medical
Microbiology, 5e.
Primary atypical pneumonia is caused by all of the following organisms,
EXCEPT:
A: Coxiella burnetii
B:
Influenz
a
C: Measles
D: Mumps virus
Correct Ans:D
Explanation
Primary atypical pneumonia is not a known complication of mumps. Clinical
manifestations of mumps includes parotitis, epididymoorchitis, aseptic
meningitis and mumps pancreatitis. Myocarditis and endocardial fibroelastosis
are rare and self-limited severe complications. Other unusual complications
include thyroiditis, nephritis, arthritis, hepatic disease, keratouveitis, and
thrombocytopenic purpura.
Features of atypical pneumonias includes:
 Exhibition of a non lobar, patchy, ill defined infiltrate on chest X
ray
 Failure to show a causative organism on gram stain or culture of
sputum as routinely performed.
Bacterial causes of atypical pneumonia includes Mycoplasma pneumoniae,
Chlamydia pneumoniae, Legionella pneumophila, Coxiella burnetii and
Chlamydophila psittaci.
Viral causes of atypical pneumonia includes Influenzae virus, respiratory
syncytial virus and adenovirus.

6. Ref: Rubin S., Carbone K.M. (2012). Chapter 194. Mumps. In D.L. Longo, A.S.
Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's
Principles of Internal Medicine, 18e. Guide to Infectious Diseases by Body System
By Jeffrey C. Pommerville page 11.
Evaluation of an adult demonstrates chronic headaches accompanied by chronic
mild nuchal rigidity. Cerebrospinal fluid sampling demonstrates a chronic
inflammatory infiltrate with lymphocytes, plasma cells, macrophages, and
fibroblasts. Which of the following is the most likely etiologic agent?
A:
Herpes
virus
B: Mumps virus
C: Mycobacterium tuberculosis
D: Neisseria meningitidis
Correct Ans:C
Explanation
Nuchal rigidity suggests meningitis. It is convenient to classify meningitis based
on the cerebrospinal fluid (CSF) findings: 1) acute pyogenic meningitis if
neutrophils are markedly increased; 2) acute lymphocytic meningitis if
lymphocytes (alone) are markedly increased, and 3) chronic meningitis if
lymphocytes, plasma cells, macrophages, and fibroblasts are increased. This
patient has chronic meningitis. The classical cause of chronic meningitis is
tuberculosis, whose etiologic agent is Mycobacterium tuberculosis. Other causes
include other indolent meningeal infections such as syphilis, brucellosis, and
chronic fungal infections.
The granulomas that are characteristic findings in other tissues may or may not
be present in the meningeal tissue, and are usually not recognizable in CSF.
Tubercular meningitis is now uncommon in this country. In immigrants from
third world countries, a history of pulmonary tuberculosis may be distant,
undiagnosed, or deliberately concealed.
Herpes virus and mumps virus are causes of acute lymphocytic
meningitis. Neisseria meningitidis and Streptococcus pneumoniae are causes of
acute pyogenic meningitis.

7. Ref: Ray C.G., Ryan K.J. (2010). Chapter 27. Mycobacteria. In C.G. Ray, K.J.
Ryan (Eds), Sherris Medical Microbiology, 5e.
Isolation is strictly recommended for:
A:
Mump
s
B: Measles
C: Hepatitis A
D: Pneumonic plague
Correct Ans:D
Explanation
Strict isolation is usually recommended in cases where it could prevent the transmission of
infection. Though isolation can be recommended in the cases of mumps and measles but
resultant effect in preventing the transmission is less compared to pneumonic plague.
Strict isolation has no role in the control of transmission of hepatitis A due to the following
two reasons:
? The shedding of virus is highest during the incubation period and during the early phase
of illness
? Sub clinical cases occur in large numbers
Ref: Park Textbook of Social and Preventive Medicine, 19th Edition, Pages 126-129, 131–
132, 173–175, 244-249
An infant develops cough and fever. The X-ray examination is suggestive of
bronchopneumonia. All of the following viruses can be the causative agent, EXCEPT:
A: Parainfluenza viruses
B:
Influenza virus
A
C: Respiratory syncytial virus
D: Mumps virus
Correct Ans:D
Explanation

8. Mumps occur between the ages of 5 & 15. Infants are rarely involved due to presence of
transplacentally acquired maternal mumps antibodies.
Ref: O P Ghai Essential Pediatrics, 6th Edition, Page 209
Which of the following is the most common cause of meningoencephalitis in children?
A: Mumps
B: Arbovirus
C: HSV
D: Enterovirus
Correct Ans:D
Explanation
80% of cases of viral meningocencephalitis are caused by enteroviral group of viruses such as
echovirus and coxsackie virus.
Ref: Adams and Victor's principles of neurology By Allan H. Ropper, Raymond Delacy
Adams, Maurice Victor, Robert H. Brown page633.
With reference to mumps which of the following is true?
A: Meningoencephalitis can precede parotitis
B: Salivary gland involvement is limited to the parotids
C: The patient is not infectious prior to clinical parotid enlargement
D: Mumps orchitis frequency leads to infertility
Correct Ans:A
Explanation
Meningoencephalitis is an extra salivary manifestation of mumps. It can develop before,
with or after the appearance of parotid swelling. Early onset encephalitis occur within 1-
2weeks of onset of illness and is due to mumps infection of brain.
Mumps can involve all the 3 salivary glands parotid, submaxillary and sublingual. Patients
are infectious 7 days prior to and 9 days after the appearance of parotid or salivary gland
swelling. Mumps orchitis rarely leads to sterility.
Ref: Essential Pediatrics, 6th Edition By O P Ghai, Page 209.

9. An infant develops cough and fever. The X-ray examination is suggestive of
bronchopneumonia. All of the following viruses can be the causative agent, EXCEPT:
A: Parainfluenza viruses
B:
Influenza virus
A
C: Respiratory syncytial virus
D: Mumps virus
Correct Ans:D
Explanation
Mumps occur between the ages of 5 & 15. Infants are rarely involved due to presence of
transplacentally acquired maternal mumps antibodies.
Ref: O P Ghai Essential Pediatrics, 6th Edition, Page 209
Which of the following is the most common cause of meningoencephalitis in children?
A: Mumps
B: Arbovirus
C: HSV
D: Enterovirus
Correct Ans:D
Explanation
80% of cases of viral meningocencephalitis are caused by enteroviral group of viruses such as
echovirus and coxsackie virus.
Ref: Adams and Victor's principles of neurology By Allan H. Ropper, Raymond Delacy
Adams, Maurice Victor, Robert H. Brown page633.
Which of the following is the most common cause of meningoencephalitis in children?

10. A: Mumps
B: Arbovirus
C: HSV
D: Enterovirus
Correct Ans:D
Explanation
Enterovirus is thought to be responsible for majority of viral
meningitis cases.
The primary cause of aseptic (nonbacterial) meningitis in children is Enterovirus.
Ref: The Central Nervous System in Pediatric Critical Illness and Injury By Derek S.
Wheeler, Hector R. Wong, Thomas P. Shanley, Page 101; Blueprints Clinical Cases in
Pediatrics By Vedang A. Londhe, Andrea K. Marmor, Abhay S. Dandekar, Page 40
Which of the following viruses does not causes pneumonia?
A:
Mump
s
B: Measles
C: RSV
D: Influenza
Correct Ans:A
Explanation
Most common viruses associated with pneumonia are:
 Influenza
 RSV
 Measles
 Chickenpox
 Hantavirus

11. Mumps does not cause pneumonia. Complications of mumps includes meningitis, orchitis,
pancreatitis, oophoritis, thyroiditis, neuritis, hepatitis, myocarditis, thrombocytopenia,
migratory arthralgia, nephritis and endocardial fibroelastosis.
A 2 year old un immunised child from a hilly tribal area developed Keratomalacia after a
viral infection. Which of the following could have lead to the development of
Keratomalacia?
A:
Rubell
a
B: Rubeola
C: Mumps
D: Varicella
Correct Ans:B
Explanation
Measles/rubeola is associated with increased catabolism and may precipitate acute vitamin
A deficiency which may lead to Keratomalacia and blindness.
The doses of Vit A to be given in case of measles is given
below:
< 6 months - 50000 IV
6 - 11 months - 100000 IV
>= 12 months - 200000 IV
Ref: Park, Edition 21, Page - 138
A 50-year-old female complains of dry mouth and foreign body sensation in her eyes. It is
difficult for her to speak for more than a few minutes. There is no history of diabetes
mellitus or neurological disease. The patient is on no medications. During clinical
examination the buccal mucosa appears dry and the salivary glands are enlarged bilaterally.
The next step in evaluation would be?
A: Use of corticosteroids
B: Schirmer test and measurement of autoantibodies
C: IgG antibody to mumps virus
D: Lip biopsy
Correct Ans:B
Explanation

12. Primary Sjogren’s syndrome, an autoimmune disease with presenting symptoms of dry eyes
and dry mouth. Positive Schirmer test is an objective evidence of dry eyes.
Autoantibodies are directed against non-organ-specific antigens such as immunoglobulins
(rheumatoid factors) and extractable nuclear and cytoplasmic antigens (Ro/SS-A, La/SS-
B). Lip biopsy also can prove the diagnosis of Sjogren’s syndrome. Noninvasive tests like
Schirmer test and measurement of autoantibodies should be the first step in the evaluation
of primary Sjogren’s syndrome.
Which is the commonest complication of Mumps in adults ?
A: Encephalitis
B:
Orchiti
s
C: Pancreatitis
D: Carditis
Correct Ans:B
Explanation
Meningoencephalitis is common in children. Unilateral deafness and thyroiditis are also known
complication.
Isolation is required to break the transmission of all the following diseases, except:
A: Swine flue
B:
Tetanu
s
C: Mumps
D: Measles
Correct Ans:B
Explanation
Tetanus is not transmitted from person to person. Its spores
or bacteria enters the body through abrasions, wounds or
umbilical stump. In presence of an anaerobic environment, it
grows and relaeses the toxin and cause the disease. Mumps,

13. measles and swine flu are spread through respiratory
droplets and require isolation to prevent transmission.
Uveoparotitis is seen in which of the following systemic conditions?
A: Sarcoidosis
B: SLE
C: Scleroderma
D: Mumps
Correct Ans:A
Explanation
Uveoparotitis (uveoparotid fever or Heerfordt's syndrome) is an uncommon manifestation
of sarcoidosis. It is characterised by bilateral granulomatous pan-uveitis, painful
enlargement of parotid glands, cranial nerve palsies, skin rashes, fever and malaise.
The patient ordinarily comes to medical attention because of visual impairment and a
painful eye. The mouth is dry and the parotid gland is swollen. Facial nerve compression
and palsy are present in 40% of cases.
Ref: Opthalmology By A. K. Khurana, 2007, Page 156