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Characteristics Exotoxins Endotoxins Source Living gram positive and gram negative bacteria Lysed gram negative bacteria Location Released from the cell Part of cell Chemical Composition Protein Lipopolysaccaride Heat Sensitivity Liable (60-80C) Stable (250C) Immune Reactions Strong Weak Conversion to Toxoids Possible Not possible Fever No Yes Enzyme Activity It has mostly enzymatic activity. It has no enzymatic activity. Molecular Weight Its molecular weight is 10KDa. Its molecular weight is 50-1000KDa. Denaturing On boiling it get denatured. On boiling it cannot be denatured. Specificity Specific to particular bacterial strain Non specific Antigencity High Poor Examples Staphylococcus aureus, Bacillus cereus, Streptococcus pyogenes, Vibrio cholera, E.coli, Salmonella typhi, Shigella.

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exotoxins and endotoxins.pptx

  • 1. Characteristics Exotoxins Endotoxins Source Living gram positive and gram negative bacteria Lysed gram negative bacteria Location Released from the cell Part of cell Chemical Composition Protein Lipopolysaccaride Heat Sensitivity Liable (60-80C) Stable (250C) Immune Reactions Strong Weak Conversion to Toxoids Possible Not possible Fever No Yes Enzyme Activity It has mostly enzymatic activity. It has no enzymatic activity. Molecular Weight Its molecular weight is 10KDa. Its molecular weight is 50-1000KDa. Denaturing On boiling it get denatured. On boiling it cannot be denatured. Specificity Specific to particular bacterial strain Non specific Antigencity High Poor Examples Staphylococcus aureus, Bacillus cereus, Streptococcus pyogenes, Vibrio cholera, E.coli, Salmonella typhi, Shigella.