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This 𝐀𝐬𝐭𝐡𝐦𝐚 animated template is designed by RxSlides, a medical professional team covering the following topics about 𝐀𝐬𝐭𝐡𝐦𝐚
𝐃𝐞𝐟𝐢𝐧𝐢𝐭𝐢𝐨𝐧
• Bronchial asthma is a lung disease that causes the airways to become narrow, swollen, and filled with mucus, making breathing difficult.
𝐩𝐫𝐞𝐯𝐚𝐥𝐞𝐧𝐜𝐞
• affects over 300 million people worldwide
• Increasing prevalence worldwide
• Highest prevalence in developed countries
• significant impact on public health
𝐑𝐢𝐬𝐤 𝐅𝐚𝐜𝐭𝐨𝐫𝐬
• Smoking
• Obesity
• Family history
• Age
𝐓𝐫𝐢𝐠𝐠𝐞𝐫𝐬:
• Irritants
• Outdoor allergens
• Viruses
• Indoor allergens
𝐏𝐚𝐭𝐡𝐨𝐩𝐡𝐲𝐬𝐢𝐨𝐥𝐨𝐠𝐲
• Allergens are picked up by dendritic cells and presented to TH2 cells.
• TH2 cells produce cytokines like IL-4 and IL-5, which activate eosinophils.
• The smooth muscle around the bronchioles spasms and secretes more mucus, narrowing the airways and making breathing harder.
• The endothelium of the lungs is damaged, leading to edema, scarring, and fibrosis.
• Reversible changes: Early inflammatory changes, including mucus production and smooth muscle contraction, can be reversed with treatment.
• Irreversible changes: Chronic inflammation and remodeling lead to structural changes in the airways, such as thickening and fibrosis, which are difficult to reverse.
• Importance of early intervention: Early diagnosis and treatment can prevent or minimize irreversible changes, improving long-term outcomes.
𝐓𝐲𝐩𝐞𝐬:
• Allergic asthma: Triggered by exposure to allergens such as dust mites, pollen, and mold.
• Seasonal asthma: Symptoms worsen during specific seasons, often linked to pollen or airborne allergens.
• Occupational asthma: Triggered by exposure to workplace irritants and chemicals.
• Non-allergic asthma: Not triggered by specific allergens, but rather by irritants, weather changes, or exercise.
• Difficult asthma: Severe and persistent asthma that requires intensive management and specialized care.
𝐒𝐲𝐦𝐩𝐭𝐨𝐦𝐬
• Sneezing
• Wheezing
• Coughing
• Shortness of breath
• Fatigue
𝐃𝐢𝐚𝐠𝐧𝐨𝐬𝐭𝐢𝐜 𝐦𝐞𝐭𝐡𝐨𝐝𝐬
• Chest X-rays
• Lung function tests
• Allergy testing
• Arterial blood gas analysis
𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐎𝐩𝐭𝐢𝐨𝐧𝐬
• Quick-relief medicines
• Short-acting beta-2 agonists
• Corticosteroids
• Animated illustrations explain how short-acting beta-2 agonists work.
• Treatment options are updated according to the latest asthma guidelines.
𝐏𝐫𝐞𝐯𝐞𝐧𝐭𝐢𝐯𝐞 𝐌𝐞𝐭𝐡𝐨𝐝𝐬:
• Taking preventive medication
• Reducing exposure to allergens
• Avoiding triggers
• Maintaining a healthy lifestyle
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3. Asthma Attack
An asthma attack is a
sudden episode of
worsening asthma
symptoms that can be
mild, moderate, or
severe. It can cause
difficulty breathing,
wheezing, coughing,
chest tightness, and
shortness of breath. In
severe cases, an
asthma attack can be
life-threatening if not
treated promptly
4. Asthma Definition
Asthma is a chronic
inflammatory lung
disease characterized
by reversible airway
narrowing. This
narrowing occurs due to
inflammation and
increased mucus
production, which leads
to airflow obstruction
and difficulty breathing.
Asthmatic airways are
also more responsive to
various triggers, such as
allergens, irritants, and
exercise.
6. Asthma Prevalence
The prevalence of
asthma is increasing
worldwide, with the
highest rates observed
in developed
countries. Asthma has
a significant impact on
public health, causing
substantial economic
burden and decreased
quality of life
7. Asthma Risk factors- smoking
• Major
risk factor for
asthma
development and
exacerbations
•
Cause
s airway
inflammation and
damage
•
Increa
ses mucus
production
•
Worse
ns asthma
symptoms
•
Smoki
ng cessation is
crucial for asthma
management
8. Asthma Risk factors – obesity
• Linked to
increased risk of
asthma development
and severity
•
Contribu
tes to airway
inflammation and
hyperresponsiveness
• May
worsen asthma
symptoms and control
• Weight
management is
essential for improving
asthma outcomes
9. Risk factors-Family History
• Strong
genetic component
to asthma
• Having
a family member
with asthma
increases risk
• Risk
increases with the
number of affected
family members
• Early
diagnosis and
intervention are
crucial
10. Risk factors- age
•
Asthm
a can develop at any
age
• More
common in children
and young adults
• Risk of
childhood asthma
increases with
exposure to
allergens and
pollutants
• Early
identification and
management are
crucial for long-term
health
15. Asthma Diagnosis
• Medical
history and physical
examination:
Assessing symptoms,
triggers, and family
history.
•
Spirom
etry: Measures lung
function and detects
airway obstruction.
• Allergy
testing: Identifies
potential allergens
triggering asthma
attacks.
• Chest
X-ray: May reveal
evidence of airway
inflammation or other
lung conditions.
22. Nom- allergic Asthma
Not triggered by
specific allergens,
but rather by
irritants, weather
changes, or exercise.
23. Difficult Asthma
Definition: Difficult
asthma is a severe
and persistent form of
asthma that requires
intensive
management and
specialized care.
Prevalence:
Approximately 5-10%
of individuals with
asthma fall into the
difficult-to-treat
category.
Characteristics:
Difficult asthma is
often characterized by
frequent and
uncontrolled
symptoms, poor
response to standard
treatment, and
significant impact on
quality of life.
24. Difficult Asthma
Risk factors: Family
history, early onset
of asthma, severe
exacerbations,
presence of allergic
rhinitis or eczema,
obesity, exposure to
environmental
triggers, and
occupational
hazards.
Comorbidities: Sleep
apnea,
gastroesophageal
reflux disease
(GERD), anxiety and
depression, and
other chronic
respiratory
conditions.
25. Asthma Types
Comprehensive
evaluation: Detailed
medical history, physical
examination, lung
function tests
(spirometry), allergy
testing, and assessment
of potential
comorbidities.
Biomarkers: Emerging
role of biomarkers, such
as FeNO (fractional
exhaled nitric oxide) and
sputum eosinophil levels,
to aid in diagnosis and
treatment monitoring.
Phenotyping:
Subcategorizing difficult
asthma based on specific
clinical characteristics
and inflammatory
pathways for
personalized treatment
approaches.
26. Childhood asthma
• Unique
challenges:
Rapidly growing
airways and
increased
susceptibility to
infections.
• Early intervention
is critical:
Establishing
proper
management
strategies to
prevent long-term
complications.
Comorbidities: May co-
occur with other
conditions like allergies
or eczema
27. Adult-onset Asthma
• Different
presentation: Symptoms
may develop later in life
and be less typical than
childhood asthma.
•
Occupatio
nal and environmental
triggers: Assessing
workplace exposures and
environmental factors is
crucial.
•
Manageme
nt adaptations:
Treatment strategies may
need to be adjusted
based on individual
needs and lifestyle
changes.
32. Reversible and irreversible bronchiole
changes
• Reversible
changes: Early
inflammatory changes,
including mucus
production and smooth
muscle contraction, can
be reversed with
treatment.
•
Irreversibl
e changes: Chronic
inflammation and
remodeling lead to
structural changes in the
airways, such as
thickening and fibrosis,
which are difficult to
reverse.
•
Importanc
e of early intervention:
Early diagnosis and
treatment can prevent or
minimize irreversible
changes, improving
long-term outcomes.
34. Asthma
• Short-acting
beta-2 agonists (SABAs):
Used for quick relief of
symptoms, such as
wheezing and shortness of
breath.
• Long-acting
beta-2 agonists (LABAs):
Used for long-term control
of asthma by preventing
airway constriction.
• Inhaled
corticosteroids (ICS): Used
for long-term control of
asthma by reducing
inflammation in the
airways.
• Combination
inhalers: Combine a LABA
and an ICS for both quick
relief and long-term
control.
• Leukotriene
modifiers: Specifically
target and block the activity
of leukotrienes, a class of
inflammatory mediators.
• Biologics:
Target specific molecules
in the immune system
involved in the
inflammatory process.
35. Short-acting beta-2 agonist mechanism of
action
• Bind
to beta-2 receptors
on airway smooth
muscle.
•
Activat
e adenylyl cyclase,
which converts ATP
to cAMP.
•
Increa
se intracellular
cAMP levels, leading
to protein kinase A
activation.
•
Phosp
horylate target
proteins, resulting in
smooth muscle
relaxation and
bronchodilation.
36. Short-acting beta-2 agonist adverse
reactions
•
Tachycar
dia (increased heart
rate)
• Tremor
•
Palpitatio
ns
• Anxiety
•
Headach
e
• Nausea
•
Hypokale
mia (low potassium
levels)
37. corticosteroids
Corticosteroids
suppress inflammation
by inhibiting the release
of inflammatory
mediators and reducing
the activity of immune
cells.
• Onset and
duration of action:
Slower onset of action
but provides long-term
control of inflammation.
• Common
medications: Inhaled
corticosteroids (ICS),
oral corticosteroids
(OCS).
38. Corticosteroids mechanism of action
• Bind to
glucocorticoid
receptors in the
cytoplasm.
•
Translo
cate to the nucleus
and bind to DNA.
•
Activat
e gene transcription
of anti-inflammatory
proteins.
• Inhibit
the release of
inflammatory
mediators, such as
cytokines and
leukotrienes.
• Reduce
inflammation in the
airways.
39. Asthma Prevention
•
Avoida
nce of triggers:
Identifying and
avoiding personal
triggers, such as
allergens and
irritants.
•
Smoki
ng cessation:
Smoking
significantly
worsens asthma and
quitting is crucial for
improving lung
function and
reducing symptoms.
•
sympt
oms.
40. Asthma prevention
Immunization:
Maintaining up-to-date
vaccinations to
prevent respiratory
infections that can
trigger asthma attacks.
• Healthy
diet and exercise:
Maintaining a healthy
weight and engaging in
regular physical
activity can improve
overall health and
reduce asthma