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Asthma
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Asthma
Asthma Definition
Asthma is a chronic
inflammatory airway
disease characterized
by recurrent episodes
of wheezing, shortness
of breath, chest
tightness, and cough
Asthma Definition
These episodes
are caused by
hypersensitivity
of the airways,
leading to
bronchoconstri
ction, airway
edema, and
mucus
plugging.
Asthma Prevalence
Asthma Prevalence
Asthma affects
approximately 27
million individuals in
the United States,
equating to about 1
in 12 people.
Children are
particularly
susceptible to
asthma, with
around 4.5 million
children under the
age of 18 having the
condition.
Asthma Prevalence
Asthma is a
prevalent chronic
respiratory
condition affecting
millions of
individuals
worldwide.
According to the
World Health
Organization
(WHO), asthma
impacted an
estimated 262
million people in
2019, causing over
455,000 death
Asthma
asthma affected
an estimated 262
million people in
2019 and caused
455 000 deaths
Normal and Asthmatic Airways
In normal airways,
the smooth muscle
surrounding the
airways is relaxed,
allowing for
unobstructed
airflow. The lining of
the airways is
covered with cilia,
which help clear
mucus and debris.
Normal and Asthmatic Airways
Normal and Asthmatic Airways
In asthmatic airways,
the smooth muscle is
hyperreactive,
constricting more
easily in response to
various stimuli. The
lining of the airways is
also inflamed,
producing excessive
mucus that can
further obstruct
airflow
Normal Respiration:
Smooth, effortless
breathing
Airflow is
unobstructed
Lungs expand and
contract freely
No wheezing or
shortness of breath
Asthmatic Respiration:
Difficulty exhaling
(expelling air from
the lungs)
Airflow is restricted
due to swollen and
narrowed airways
Lungs become
trapped with air,
making it hard to
breathe out
completely
Wheezing, a
whistling sound
during breathing, is
a common
symptom
Shortness of
breath, especially
during activities or
when exposed to
triggers, is also a
common symptom
Asthma pathpphysiology
The immunological
response plays a
central role in the
development and
progression of
asthma. This
response is
characterized by an
exaggerated Th2-
type immune
response, which
leads to the
production of high
levels of IgE
antibodies. These
IgE antibodies bind
to allergens and
trigger the release of
inflammatory
mediators from mast
cells, which
contributes to the
airway inflammation
characteristic of
asthma.
Asthma pathophysiology
Asthma
Interleukin-4 (IL-4): IL-4
is a key mediator of Th2
cell differentiation and is
involved in IgE antibody
production. It also
promotes the
proliferation and
activation of eosinophils,
which are inflammatory
cells that are increased
in the airways of people
with asthma.
Interleukin-5 (IL-5): IL-5
is responsible for the
differentiation, survival,
and activation of
eosinophils. It also plays
a role in the recruitment
of eosinophils to the
airways.
Asthma Pathogenesis
Asthma is a
complex chronic
inflammatory
disorder that
involves a
multitude of
factors, including
airway
inflammation,
hyperresponsivene
ss of the airways,
and remodeling of
the airway wall.
The immunological
response plays a
central role in the
development and
progression of
asthma,
characterized by
an exaggerated
Th2-type immune
response and IgE
antibody
production
Asthma Symptoms
• Wheezing: A
whistling sound
produced during
exhalation
• Shortness of
breath: Difficulty
breathing,
especially during
exercise or when
lying down
• Chest tightness: A
feeling of
pressure or
tightness in the
chest
• Cough: A
persistent cough
that may be
productive of
mucus
Asthma Risk factors
• Family history
of asthma
• Personal
history of
allergies or
eczema
• Exposure to
environmental
allergens and
irritants
• Obesity
• Vitamin D
deficiency
• Preterm birth or
low birth weight
• Frequent
respiratory
infections in
early childhood
Asthma Types
Mild asthma
Moderate
asthma
Sever asthma
Asthma Types
Asthma Types
Asthma Types
• Allergic asthma:
Triggered by
exposure to specific
allergens
• Non-allergic asthma:
Not triggered by
specific allergens but
may be exacerbated
by environmental
irritants, infections, or
exercise
• Occupational asthma:
Caused by exposure
to workplace irritants
or allergens
Asthma Types
Asthma Diagnosis
• Spirometry:
Measures lung
function by
assessing airflow
volumes
• Peak expiratory flow
(PEF) monitoring:
Tracks daily PEF
readings to identify
patterns of airway
obstruction
• Allergy testing:
Identifies specific
allergens that may
trigger asthma
symptoms
Asthma Treatment
• Inhaled
corticosteroids
(ICS): The
mainstay of long-
term asthma
control
• Long-acting
beta2-agonists
(LABAs): Provide
bronchodilation
for extended
periods
• Leukotriene
modifiers: Block
the action of
leukotrienes,
inflammatory
mediators
involved in
asthma
Asthma Prevention
• Identifying and
avoiding personal
triggers
• Maintaining a
healthy lifestyle,
including regular
exercise and a
balanced diet
• Controlling allergies
and managing
environmental
exposures
• Getting regular
vaccinations,
especially flu and
pneumonia
vaccines
• Adhering to
prescribed asthma
medications and
treatment

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Asthma

  • 3. Asthma Definition Asthma is a chronic inflammatory airway disease characterized by recurrent episodes of wheezing, shortness of breath, chest tightness, and cough
  • 4. Asthma Definition These episodes are caused by hypersensitivity of the airways, leading to bronchoconstri ction, airway edema, and mucus plugging.
  • 6. Asthma Prevalence Asthma affects approximately 27 million individuals in the United States, equating to about 1 in 12 people. Children are particularly susceptible to asthma, with around 4.5 million children under the age of 18 having the condition.
  • 7. Asthma Prevalence Asthma is a prevalent chronic respiratory condition affecting millions of individuals worldwide. According to the World Health Organization (WHO), asthma impacted an estimated 262 million people in 2019, causing over 455,000 death
  • 8. Asthma asthma affected an estimated 262 million people in 2019 and caused 455 000 deaths
  • 9. Normal and Asthmatic Airways In normal airways, the smooth muscle surrounding the airways is relaxed, allowing for unobstructed airflow. The lining of the airways is covered with cilia, which help clear mucus and debris.
  • 11. Normal and Asthmatic Airways In asthmatic airways, the smooth muscle is hyperreactive, constricting more easily in response to various stimuli. The lining of the airways is also inflamed, producing excessive mucus that can further obstruct airflow
  • 12. Normal Respiration: Smooth, effortless breathing Airflow is unobstructed Lungs expand and contract freely No wheezing or shortness of breath
  • 13. Asthmatic Respiration: Difficulty exhaling (expelling air from the lungs) Airflow is restricted due to swollen and narrowed airways Lungs become trapped with air, making it hard to breathe out completely Wheezing, a whistling sound during breathing, is a common symptom Shortness of breath, especially during activities or when exposed to triggers, is also a common symptom
  • 14. Asthma pathpphysiology The immunological response plays a central role in the development and progression of asthma. This response is characterized by an exaggerated Th2- type immune response, which leads to the production of high levels of IgE antibodies. These IgE antibodies bind to allergens and trigger the release of inflammatory mediators from mast cells, which contributes to the airway inflammation characteristic of asthma.
  • 16. Asthma Interleukin-4 (IL-4): IL-4 is a key mediator of Th2 cell differentiation and is involved in IgE antibody production. It also promotes the proliferation and activation of eosinophils, which are inflammatory cells that are increased in the airways of people with asthma. Interleukin-5 (IL-5): IL-5 is responsible for the differentiation, survival, and activation of eosinophils. It also plays a role in the recruitment of eosinophils to the airways.
  • 17. Asthma Pathogenesis Asthma is a complex chronic inflammatory disorder that involves a multitude of factors, including airway inflammation, hyperresponsivene ss of the airways, and remodeling of the airway wall. The immunological response plays a central role in the development and progression of asthma, characterized by an exaggerated Th2-type immune response and IgE antibody production
  • 18. Asthma Symptoms • Wheezing: A whistling sound produced during exhalation • Shortness of breath: Difficulty breathing, especially during exercise or when lying down • Chest tightness: A feeling of pressure or tightness in the chest • Cough: A persistent cough that may be productive of mucus
  • 19. Asthma Risk factors • Family history of asthma • Personal history of allergies or eczema • Exposure to environmental allergens and irritants • Obesity • Vitamin D deficiency • Preterm birth or low birth weight • Frequent respiratory infections in early childhood
  • 23. Asthma Types • Allergic asthma: Triggered by exposure to specific allergens • Non-allergic asthma: Not triggered by specific allergens but may be exacerbated by environmental irritants, infections, or exercise • Occupational asthma: Caused by exposure to workplace irritants or allergens
  • 25. Asthma Diagnosis • Spirometry: Measures lung function by assessing airflow volumes • Peak expiratory flow (PEF) monitoring: Tracks daily PEF readings to identify patterns of airway obstruction • Allergy testing: Identifies specific allergens that may trigger asthma symptoms
  • 26. Asthma Treatment • Inhaled corticosteroids (ICS): The mainstay of long- term asthma control • Long-acting beta2-agonists (LABAs): Provide bronchodilation for extended periods • Leukotriene modifiers: Block the action of leukotrienes, inflammatory mediators involved in asthma
  • 27. Asthma Prevention • Identifying and avoiding personal triggers • Maintaining a healthy lifestyle, including regular exercise and a balanced diet • Controlling allergies and managing environmental exposures • Getting regular vaccinations, especially flu and pneumonia vaccines • Adhering to prescribed asthma medications and treatment