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𝗵𝘁𝘁𝗽𝘀://𝘄𝘄𝘄.𝗿𝘅𝘀𝗹𝗶𝗱𝗲𝘀.𝗰𝗼𝗺
𝐓𝐡𝐞 𝐭𝐞𝐦𝐩𝐥𝐚𝐭𝐞 𝐜𝐨𝐯𝐞𝐫𝐬 𝐭𝐡𝐞 𝐟𝐨𝐥𝐥𝐨𝐰𝐢𝐧𝐠 𝐭𝐨𝐩𝐢𝐜𝐬
𝐃𝐞𝐟𝐢𝐧𝐢𝐭𝐢𝐨𝐧
𝐀𝐬𝐭𝐡𝐦𝐚 is a chronic inflammatory airway disease characterized by recurrent episodes of wheezing, shortness of breath, chest tightness, and cough.
𝐀𝐧𝐚𝐭𝐨𝐦𝐲 𝐨𝐟 𝐍𝐨𝐫𝐦𝐚𝐥 𝐚𝐧𝐝 𝐀𝐬𝐭𝐡𝐦𝐚𝐭𝐢𝐜 𝐀𝐢𝐫𝐰𝐚𝐲𝐬
In normal airways, the smooth muscle surrounding the airways is relaxed, allowing for unobstructed airflow.
In asthmatic airways, the smooth muscle is hyperreactive, constricting more easily in response to various stimuli.
𝐜𝐚𝐮𝐬𝐞𝐬
• Exposure to allergens such as dust mites, pollen, mold, and pet dander
• Exposure to air pollutants such as cigarette smoke and secondhand smoke
• Viral respiratory infections
• Occupational exposure to irritants or chemicals
𝐒𝐲𝐦𝐩𝐭𝐨𝐦𝐬
• Wheezing
• Shortness of breath
• Chest tightness
• Cough
𝐏𝐚𝐭𝐡𝐨𝐩𝐡𝐲𝐬𝐢𝐨𝐥𝐨𝐠𝐲
. When an individual with asthma is exposed to an allergen or irritant, their immune system mounts an exaggerated inflammatory response, leading to bronchoconstriction, airway edema, and mucus plugging.
𝐃𝐢𝐚𝐠𝐧𝐨𝐬𝐭𝐢𝐜 𝐦𝐞𝐭𝐡𝐨𝐝𝐬
• Spirometry
• Peak expiratory flow (PEF) monitoring
• Allergy testing
𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐎𝐩𝐭𝐢𝐨𝐧𝐬 T
• Inhaled corticosteroids (ICS): The mainstay of long-term asthma control
• Long-acting beta2-agonists (LABAs): Provide bronchodilation for extended periods
• Leukotriene modifiers: Block the action of leukotrienes, inflammatory mediators involved in asthma
𝐓𝐲𝐩𝐞𝐬
• Allergic asthma: Triggered by exposure to specific allergens
• Non-allergic asthma: Not triggered by specific allergens but may be exacerbated by environmental irritants, infections, or exercise
• Occupational asthma: Caused by exposure to workplace irritants or allergens
𝐂𝐨𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬
• Frequent asthma attacks requiring emergency care
• Hospitalization due to severe asthma exacerbations
• Impaired lung function and reduced quality of life
• Increased risk of respiratory infections
• Psychological distress and anxiety
𝐏𝐫𝐞𝐯𝐞𝐧𝐭𝐢𝐯𝐞 𝐌𝐞𝐭𝐡𝐨𝐝𝐬
• Identifying and avoiding personal triggers
• Maintaining a healthy lifestyle, including regular exercise and a balanced diet
• Controlling allergies and managing environmental exposures
• Getting regular vaccinations, especially flu and pneumonia vaccines
• Adhering to prescribed asthma medications and treatment
3. Asthma Definition
Asthma is a chronic
inflammatory airway
disease characterized
by recurrent episodes
of wheezing, shortness
of breath, chest
tightness, and cough
4. Asthma Definition
These episodes
are caused by
hypersensitivity
of the airways,
leading to
bronchoconstri
ction, airway
edema, and
mucus
plugging.
6. Asthma Prevalence
Asthma affects
approximately 27
million individuals in
the United States,
equating to about 1
in 12 people.
Children are
particularly
susceptible to
asthma, with
around 4.5 million
children under the
age of 18 having the
condition.
7. Asthma Prevalence
Asthma is a
prevalent chronic
respiratory
condition affecting
millions of
individuals
worldwide.
According to the
World Health
Organization
(WHO), asthma
impacted an
estimated 262
million people in
2019, causing over
455,000 death
9. Normal and Asthmatic Airways
In normal airways,
the smooth muscle
surrounding the
airways is relaxed,
allowing for
unobstructed
airflow. The lining of
the airways is
covered with cilia,
which help clear
mucus and debris.
11. Normal and Asthmatic Airways
In asthmatic airways,
the smooth muscle is
hyperreactive,
constricting more
easily in response to
various stimuli. The
lining of the airways is
also inflamed,
producing excessive
mucus that can
further obstruct
airflow
13. Asthmatic Respiration:
Difficulty exhaling
(expelling air from
the lungs)
Airflow is restricted
due to swollen and
narrowed airways
Lungs become
trapped with air,
making it hard to
breathe out
completely
Wheezing, a
whistling sound
during breathing, is
a common
symptom
Shortness of
breath, especially
during activities or
when exposed to
triggers, is also a
common symptom
14. Asthma pathpphysiology
The immunological
response plays a
central role in the
development and
progression of
asthma. This
response is
characterized by an
exaggerated Th2-
type immune
response, which
leads to the
production of high
levels of IgE
antibodies. These
IgE antibodies bind
to allergens and
trigger the release of
inflammatory
mediators from mast
cells, which
contributes to the
airway inflammation
characteristic of
asthma.
16. Asthma
Interleukin-4 (IL-4): IL-4
is a key mediator of Th2
cell differentiation and is
involved in IgE antibody
production. It also
promotes the
proliferation and
activation of eosinophils,
which are inflammatory
cells that are increased
in the airways of people
with asthma.
Interleukin-5 (IL-5): IL-5
is responsible for the
differentiation, survival,
and activation of
eosinophils. It also plays
a role in the recruitment
of eosinophils to the
airways.
17. Asthma Pathogenesis
Asthma is a
complex chronic
inflammatory
disorder that
involves a
multitude of
factors, including
airway
inflammation,
hyperresponsivene
ss of the airways,
and remodeling of
the airway wall.
The immunological
response plays a
central role in the
development and
progression of
asthma,
characterized by
an exaggerated
Th2-type immune
response and IgE
antibody
production
18. Asthma Symptoms
• Wheezing: A
whistling sound
produced during
exhalation
• Shortness of
breath: Difficulty
breathing,
especially during
exercise or when
lying down
• Chest tightness: A
feeling of
pressure or
tightness in the
chest
• Cough: A
persistent cough
that may be
productive of
mucus
19. Asthma Risk factors
• Family history
of asthma
• Personal
history of
allergies or
eczema
• Exposure to
environmental
allergens and
irritants
• Obesity
• Vitamin D
deficiency
• Preterm birth or
low birth weight
• Frequent
respiratory
infections in
early childhood
23. Asthma Types
• Allergic asthma:
Triggered by
exposure to specific
allergens
• Non-allergic asthma:
Not triggered by
specific allergens but
may be exacerbated
by environmental
irritants, infections, or
exercise
• Occupational asthma:
Caused by exposure
to workplace irritants
or allergens
25. Asthma Diagnosis
• Spirometry:
Measures lung
function by
assessing airflow
volumes
• Peak expiratory flow
(PEF) monitoring:
Tracks daily PEF
readings to identify
patterns of airway
obstruction
• Allergy testing:
Identifies specific
allergens that may
trigger asthma
symptoms
26. Asthma Treatment
• Inhaled
corticosteroids
(ICS): The
mainstay of long-
term asthma
control
• Long-acting
beta2-agonists
(LABAs): Provide
bronchodilation
for extended
periods
• Leukotriene
modifiers: Block
the action of
leukotrienes,
inflammatory
mediators
involved in
asthma
27. Asthma Prevention
• Identifying and
avoiding personal
triggers
• Maintaining a
healthy lifestyle,
including regular
exercise and a
balanced diet
• Controlling allergies
and managing
environmental
exposures
• Getting regular
vaccinations,
especially flu and
pneumonia
vaccines
• Adhering to
prescribed asthma
medications and
treatment