Flexura Tablets (Generic Metaxalone Tablets) are used along with rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mechanism of action of this medicine is not clearly known, but may be related to its sedative properties. Metaxalone tablets does not directly relax tense skeletal muscles in man. Flexura is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects.

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Flexura Tablets (Generic Metaxalone Tablets)

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Flexura Tablets (Generic Metaxalone Tablets)
Flexura Tablets (Generic Metaxalone Tablets) are used
along with rest, physical therapy, and other measures for
the relief of discomforts associated with acute, painful
musculoskeletal conditions.
The mechanism of action of this medicine is not clearly
known, but may be related to its sedative properties.
Metaxalone tablets does not directly relax tense skeletal
muscles in man. Flexura is considered to be a
moderately strong muscle relaxant, with relatively low
incidence of side effects.

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Flexura Tablets (Generic Metaxalone Tablets)
Active Ingredient
The active ingredient present in Flexura tablets is
Metaxalone.
Each Flexura tablet contains 400 mg of Metaxalone.

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Flexura Tablets (Generic Metaxalone Tablets)
Chemical Structure
The structure of Metaxalone is given below:

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Flexura Tablets (Generic Metaxalone Tablets)
Flexura tablets, manufactured by Sun Pharmaceutical
Industries Limited, India are available in the strength of
400 mg.
(Website: https://sunpharma.com/ )
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Flexura Tablets (Generic Metaxalone Tablets)
Metaxalone Tablets – Brand Names
Metaxalone tablets are available under
various drug trade names that include
Skelaxin and Flexura.
It is also available in combination with
other medications under various brand
names.

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Flexura Tablets (Generic Metaxalone Tablets)
Uses of Flexura Tablets
Flexura Tablets (Generic Metaxalone Tablets) is used to help relax
the muscles in your body and relieve the discomfort caused by acute
(short-term), painful muscle or bone conditions. However, this
medicine does not take the place of rest, exercise, physical therapy,
or other treatments that your doctor may recommend for your
condition.
Metaxalone is a skeletal muscle relaxant. It acts on the central
nervous system (CNS) to relax muscles.
The mode of action of this medication has not been clearly
identified, but may be related to its sedative properties. Metaxalone
does not directly relax tense skeletal muscles in man.
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Flexura Tablets (Generic Metaxalone Tablets)
Flexura Tablets Dosage
The dosage of Flexura tablets (Generic Metaxalone
Tablets) is given below:
The recommended dosage of Generic Metaxalone (Flexura
Tablets) for adults and children over 12 years of age is one
400 mg tablet orally, three to four times a day.
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Flexura Tablets (Generic Metaxalone Tablets)
Contraindications
Flexura tablets are contraindicated in patients with a
hypersensitivity to Metaxalone or any other component of this
medication.
This medicine is also contraindicated in patients with a Known
tendency to drug induced, hemolytic, or other anemias as well
as patients with Significantly impaired renal or hepatic function.
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Flexura Tablets (Generic Metaxalone Tablets)
Storage Instructions
Flexura tablets (Generic Metaxalone tablets)
have to be stored at controlled room
temperature i.e. from 20°C to 25°C (68°F to
77°F) with excursions permitted between 15°
to 30°C (59° to 86°F).
Keep this as well as all other medicines away
from children and pets.
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Flexura Tablets (Generic Metaxalone Tablets)
Warnings
Cases of Serotonin syndrome, a potentially life-threatening condition ,
have been observed during concomitant use of serotonergic drugs with
Flexura Tablets (Generic Metaxalone) used within the recommended
dosage range and with Flexura tablets as a single agent taken at doses
higher than the recommended dose.
Flexura Tablets (Generic Metaxalone) could increase the effects of
alcohol and other CNS depressants.
Metaxalone tablets should be administered with great care to patients
with pre-existing liver damage. Serial liver function studies should be
performed in these patients.
False-positive Benedict's tests, due to an unknown reducing substance,
have been noted. A glucose-specific test will differentiate findings.

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Flexura Tablets (Generic Metaxalone Tablets)
Warnings
Taking Flexura tablets with food may enhance general CNS depression;
elderly patients may be especially susceptible to this CNS effect.
Generic Metaxalone could impair mental and/or physical abilities
necessary for performance of hazardous tasks, such as operating
machinery or driving a motor vehicle, especially when used with
alcohol or other CNS depressants.
Flexura Tablets (Generic Metaxalone) could increase the effects of
alcohol, barbiturates and other CNS depressants.
The sedative effects of Generic Metaxalone tablets and other CNS
depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic
antidepressants (TCAs)) may be additive. Exercise caution with patients
who take more than one of these CNS depressants simultaneously.

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Flexura Tablets (Generic Metaxalone Tablets)
Driving or Operating Heavy Machinery
Flexura tablets (Generic Metaxalone) may impair mental
and/or physical abilities required for performance of
hazardous tasks, such as operating machinery or driving a
motor vehicle, especially when used with alcohol or other CNS
depressants.

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Flexura Tablets (Generic Metaxalone Tablets)
Side Effects
The most frequent Metaxalone (Flexura Tablets)Side effects include:
CNS: drowsiness, dizziness, headache, and nervousness or “irritability”;
Digestive: nausea, vomiting, gastrointestinal upset.
Other side effects are:
Immune System: hypersensitivity reaction, rash with or without pruritus;
Hematologic: leukopenia; hemolytic anemia;
Hepatobiliary: jaundice.
Though rare, anaphylactoid reactions have been reported with
Metaxalone.
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Flexura Tablets (Generic Metaxalone Tablets)
Overdose
Deaths by deliberate or accidental overdose have occurred with
Metaxalone tablets, particularly in combination with antidepressants and
have been reported with this class of medications in combination with
alcohol. Serotonin syndrome has been reported when Flexura tablets
were used at doses higher than the recommended dose.
When determining the LD 50 (Median lethal dose) in rats and mice,
progressive sedation, hypnosis and finally respiratory failure were noted
as the dosage increased.
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Flexura Tablets (Generic Metaxalone Tablets)
Overdose
Gastric lavage and supportive therapy is recommended in
cases of overdose. Consultation with a regional poison
control center is also recommended.
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Flexura Tablets (Generic Metaxalone Tablets)
Flexura Tablets During Pregnancy
Metaxalone (Flexura Tablets) has been classified by the US
FDA as Pregnancy Category B.
Reproduction studies in rats have not revealed evidence of
impaired fertility or harm to the fetus due to Metaxalone.
There are, however, no adequate and well-controlled
studies in pregnant women.
Because animal reproduction studies are not always
predictive of human response, this medicine can be used
during pregnancy only if clearly needed.
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Flexura Tablets (Generic Metaxalone Tablets)
For more details on
Flexura Tablets click here
Flexura Tablets (Generic Metaxalone Tablets) by Sun
Pharmaceutical Industries Limited, India.
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