Concept map with key points regarding B. anthracis Partner: L.R.

1.  Edema factor
 Lethal factor
 Protective antigenfactor
 Malignant pustule
(black eschar)
 Nonpittingedema
 Warfare
 Hemorrhagic
meningoencephalitis
 Hemorrhagic mediastinal
adenopathy
 Oropharyngeal swelling
 Septicemia (death)
 Hemorrhagic diarrhea
Bacillus
Anthracis
General
Features
Pathogenesis
Lab
Diagnosis
Types of
Anthrax
Treatment
Prevention
 Septum
 Blood
 CSF
 Skin biopsy(PCR)
 Medusa head
appearance
 Gamma-
hemolytic
 Bamboostick
appearance
 Gram +ve
Factors Capsule
 D-glutamic acid
 Gram +ve bacilli
 Gamma-
hemolytic
 Catalase positive
 Causative agent
for Anthrax
Vaccine with
alum adjuvant
and protective
antigen
Antibiotic
prophylaxis
Ciprofloxacin
Doxycycline
Rifampin
Penicillin
Vancomycin, etc.
+
Louis
Pasteur
Demonstrated
by R. Koch
Cutaneous
Gastrointestinal
Inhalational
Virulence Factors
Specimen
Gram stain
Bloodagar
Motilitytest
 Nonmotile
India Ink
Staining
Determining
stain
Anthrax = ‘coal’
(black eschar)
Endospores require
autoclaving to be destroyed
Edema factor acts as adenylate
cyclase, causing water and
electrolyte secretion from cell
Bacillus anthracis has
been used for
bioterrorism in the US
95% of anthrax cases in humans are cutaneous