What is E coli? Solution E.coli is a bacteria that normally live in the intestine of humans or animals some type of E.coli can form infection which can cause diarrhea, abdominal pain, and fever if the infection is severe it can cause bloody diarrhea even kidney failure. E. coli is most studied free living organism indeed some of the E.coli are beneficial. the major cause for E.coli infection is the contaminated food. Molecular biologist love E.coli because they have some features that make them perfect DNA and protein producing facteries for genetic engineering. They have a short life span of (20 min betwwen two cell division) can cultivated easily in large amount under very simple condition they contains circular DNA in addition to Nucleoid. Such extrachromosomal circular DNA molecule are called plasmids..