What domain is horizontal gene transfer most common within? Multiple choice Horizontal gene transfer is common to all domains. Archaea Bacteria Bacteria and Eukarya Eukarya Solution Horizontal gene transfer is a mechanism by which short DNA fragments are transferred between organisms by direct uptake from environment (not via reproduction). It is most common in prokaryotes, although it occurs in other domains also. Horizontal gene transfer is a mechanism by which short DNA fragments are transferred between organisms by direct uptake from environment (not via reproduction). It is most common in prokaryotes, although it occurs in other domains also.Ans: c- bacteria.