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A female carrier of Tay-Sachs wants to have a child with a male carrier for Tay-Sachs. Tay-
Sachs is inherited in an autosomal recessive manner. Using the letters "T" and T fill out the
following table.
Solution
Autosomal recessive conditions are associated with non sex chromosomes and the disease allele
must be present in homozygous condition to inflict the disease. Tay-Sachs is a sphingolipidoses
associated with mutation in the HEXA gene situated on the chromosome 15. A defective copy of
both the allele for HEXA gene will lead to Tay sachs. Lets say that the wild type HEXA gene is
T and defective gene is t.
genotype of Mother - Tt; phenotype of mother- carrier
genotype of father-Tt; phenotype of father- carrier
Cross between the two:
Parents: Tt X Tt
offsprings: TT; Tt; Tt; ttFemaleMaleGenotypeTT; Tt; Tt; ttTT; Tt; Tt; ttPhenotypeNormal;
carrier; carrier; affectedNormal; carrier; carrier; affectedGenotypes of sperm/ovaSame as the
individualsame as the individual

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