A self-reactive B cell with IgM that recognizes self-antigens can become anergic under certain circumstances. When a self-reactive cell is activated by encountering its specific self-antigen, it undergoes rewiring of its cellular processes and becomes non-responsive or anergic. This process of inducing anergy in self-reactive cells is helpful for conditions where it is necessary to reduce a patient's immunity, such as organ transplantation.

1. There are three possible fates for immature B cells with IgM that recognizes self-antigens...
Under what circumstances would a self-reactive cell become anergic?
Solution
Self reactive cell activated when cell is encountered by their specific antigen and cell undergoing
rewiring of cellular processes. In response of antigen reactive cell become non responsive
(anergic)
This helpful in certain condition where requirement to reduce immunity of patient like organ
transfer or any other.