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True or False?Translesion synthesis is carried out by an error -prone DNA polymerase which
replicates past damaged DNA without regard to whether a mutation in the DNA sequence is
introduced.The age of the mother but not the father correlates with birth defects caused by point
mutations.Forward genetics refers to starting with a phenotype and figuring out the underlying
genetics.Codon bias refers to the preference for ribosomes to translate certain mRNA molecules
but not others.One of the most challenging aspects of sequencing a large genome like human is
the presence of a large amount of repetitive sequences which makes it difficult to align
sequenced fragments.Exome sequencing refers to sequencing just the introns in the human
genome in order to identify splice sites.In order to identify links to human disease from genetic
data, as in Genome Wide Association Studies (GWAS), one must sequence the entire human
genome.Mouse knockout technology consists of deleting the target gene from the genome of
mouse embryonic stem cells followed by implantation of those cells into a human blastocyst.The
mouse insulin 1 gene is a paralog of the human insulin 2 gene.Synteny refers to large portions of
chromosomes that are highly similar between two species such as human and mouse.
True or False?

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