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Mosquito Repellents


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Mosquito Repellents

  1. 1. Mosquito qRepellents
  2. 2. Mosquito Repellent q pAny Substance applied to ‐ Skin, Ski ‐ Clothing ‐ Other surfaceswhich discourages insects (& arthropods)from landing or climbing on that surfaceis called Insect Repellents.Insect repellents help Prevent & Control the outbreakof i f insect‐borne di tb diseases such as malaria. P t animals h l i Pest i lcommonly serving as vectors for disease include theinsects flea, fly, and mosquito; and the arachnid tick.
  3. 3. Repellent Formulations
  4. 4. Repellent Formulations
  5. 5. Repellent Formulations
  6. 6. Repellent Formulations
  7. 7. Selected ‐ Mosquito RepellentDEET: (N,N‐diethyl‐m‐toluamide or N,N‐diethly‐3‐methyl‐benzamide)methyl benzamide)Picaridin: (KBR 3023), 2‐(2‐hydroxyethyl)‐1‐piperidinecarboxylic acid 1‐methylpropyl ester )Oil of Lemon Eucalyptus* or PMD (para‐Menthane‐3,8‐ yp (p ,diol) the synthesized version of oil of lemon eucalyptusIR3535 (Chemical Name: 3 [N Butyl N acetyl] (Chemical Name: 3‐[N‐Butyl‐N‐acetyl]‐aminopropionic acid, ethyl ester)Permethrin: Oil of Citronella: 
  8. 8. Selected ‐ Mosquito Repellent Available FormulationsDEET: is available in multiple formulations, includingsolutions, lotions, creams, gels,solutions lotions creams gels aerosol and pumpsprays, and impregnated towelettesPicaridin:Pi idi Sprays, P S Pump, L ti Lotion, C Creams, Li id LiquidsPMD: Spray and a LotionIR3535: Lotions, Creams, Gels, Sprays.Permethrin Sprays (Only for Cloths)Oil of Citronella: Sprays, Lotions,Creams,Arosoles
  9. 9. Selected ‐ Mosquito RepellentAvailable / Allowable Concentrations DEET: from 5‐40% and 100%. Picardine:  Picardine: 5 20% 5‐20% PMD:        30‐40 % IR3535:     7.5‐15%, and 20% Permethrin:  Permethrin: 4 to 70 % 4 to 70 % Oil of Citronella:  0.1% to 10%
  10. 10. Selected ‐ Mosquito Repellent Protection TimeDEET: Depending on Concentration, 5‐12 HoursPicaridin: 2 8 hours, 2‐8 hoursPMD: 2‐3 hoursIR3535: 2.7‐4 hoursPermethrin T apply t clothing, spray each side ofP th i To l to l thi h id fthe fabric (outdoors) for 30‐45 seconds. The clothingshould then be allowed to dry for 2‐4 hours beforebeing worn. Its potency for at least 2 weeksOil of Citronella: 30‐60 minutes.
  11. 11. Selected ‐ Mosquito Repellent Peadiatric Use DEET: The American Academy of Pediatrics currentlyrecommends that children older than 2 months cansafely use DEET up to 30% concentration.Picaridin:Pi idi Can be C b used S f l d SafelyPMD: Can be used safelyIR3535: Can be used safelyPermethrin: Should not be usedOil of Citronella: Should not use under 3 years children
  12. 12. Selected ‐ Mosquito Repellent Toxicity DEET: Neutotoxicity ‐ if used at higher concentrationPicaridin: The li i d d i idi h limited data available on this product il bl hi dsuggests that it has low potential for toxicity.PMD: The synthesized version of oil of lemon eucalyptusshows no adverse effects except for eye irritationIR3535: not harmful when ingested, inhaled, or used onskin. Eye irritation could occur if the chemical enters apersons eyes.
  13. 13. Selected ‐ Mosquito Repellent Toxicity Permethrin: Likely to be Carcinogenic to Humans” bythe oral route Very high doses will have tangible route.neurotoxic effects on mammals and birds, includinghuman beings.“Oil of Citronella Oil of Citronella has been usedextensively since 1948 without any reports of adverseeffects of concern.
  14. 14. Selected ‐ Mosquito Repellent Some Other Important Points DEET ‐ Contact with plastics (eg watch crystals (eg, crystals,eyeglass frames), rayon, spandex, and painted orvarnished surfaces should be avoided becauseDEET can damage these surfaces.Picaridin: The repellent is cosmetically pleasant p y pand does not harm plastics or fabric.
  15. 15. Synthetic ‐ Mosquito RepellentSynthetic repellents tend to be more effective /longer. Lasting than "natural" repellents. Essential oilrepellents can be short‐lived in their effectiveness,since essential oils can evaporate completely.In comparative studies, IR3535 was as effective or p ,better than DEET in protection against mosquitoes.A test of various insect repellents by an independentconsumer organization found that repellentscontaining DEET or picaridin are more effective thanrepellents with " ll h "natural“ active ingredients. l“ d
  16. 16. Safety ‐ Mosquito RepellentChildren may be at greater risk for adversereactions to repellents, in part, because theirexposure may be greater. Keep repellents out of the reach of children. ‐ Do not allow children to apply repellents to themselves. ‐ Use only small amounts of repellent on children. ‐ Do not apply repellents to the hands of you g c d e young children because this may result in s ay esu accidental eye contact or ingestion.
  17. 17. Safety ‐ Mosquito RepellentChildren may be at greater risk for adversereactions to repellents, in part, because theirexposure may be greater.‐ Try to reduce the use of repellents by dressing children in long sleeves and long pants tucked into boots or socks whenever possible. Use netting over strollers, playpens, etc. tti t ll l t‐ As with chemical exposures in general, pregnant women should take care to avoid exposures to repellents when practical, as the fetus may be vulnerable vulnerable.
  18. 18. Other Mosquito Repellent (Natural)There are many preparations from naturally occurringsources that are repellent to certain insects. Some ofthese act as insecticides while others are only repellent. ‐ Lemon Eucalyptus (Corymbia Citriodora) essential oil and its active ingredient p‐ g p menthane‐3,8‐ diol (PMD) ‐ Neem Oil (Azadirachta Indica) (Repels or kills mosquitoes, their larvae and a plethora of other insects including those in agriculture)
  19. 19. Other Mosquito Repellent (Natural)There are many preparations from naturally occurring y p p y gsources that are repellent to certain insects. Some ofthese act as insecticides while others are only repellent. Achillea alpina Eucalyptus oil Alpha Terpinene (70%+ eucalyptol) Carvacrol Fennel oil Castor il C t oil (Foeniculum vulgare) (F i l l ) (Ricinus communis) Lemongrass oil Catnip oil (Cymbopogon species) Cedar il C d oil Citronella oil Rosemary Cloves Oil (Rosmarinus officinalis) Celery extract y Tea tree oil (Apium graveolens) Thyme (Thymus species)
  20. 20. Market Need for Mosquito RepellentWe understand that Pharmaceutical / Consumer productpcompanies, may offer formulations (Cream – Gel &Lotions) to protect common persons. We may offer ‐ Bulk Material to formulation in Pakistan ‐ Ready to fill solutions to pack in Pakistan ‐ Product in Ready to Sell PackagingFor pricing & other details, please provide; ‐ Your Market Review ‐ Your Marketing & Business Plan Please Contact:- M. Hassan Ansari Asiya Riaz Siddiqui Manager Marketing Doctor of Pharmacy
  21. 21. Need More Details Details, Please Talk to usM. Hassan Ansarii Asiya Riaz Siddiqui i i iddi iManager Marketing Doctor of Ch l h Chemicals i l Repharm S h Services iA – 119, Block – 5, Main Sardar Ali Sabri Road,Gulshane Iqbal - 5, Karachi - 75300, Pakistan