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  1. 1. Anatomical Parts of Stomach
  2. 2. Fundus of Stomach Gastric Rugae (GR) Longitudinal branching Folds in empty stomach. GR 4 Layers: 1) Mucosa (M) 2) Submucosa (SM) 3) Musculosa ; *Inner oblique (IO) *Middle Circular (MC) *Outer Longitudinal (OL) 4) Serosa M SM IO MC OL
  3. 3. Wall of Fundus of the Stomach Mucosa, Submucosa, Musculosa & Serosa
  4. 4. Parts & Cells of Fundic Glands
  5. 5. Fundic Glands: * Occupy most of mucosal thickness. * Perpendicular to the surface, reaching to muscularis mucosa (MM). MM *Very Crowded Minimal C.T. .
  6. 6. * Simple Branched Tubular Glands. * Open into lumen by short narrow ducts (Gastric Pits) * Pit: Secretory Portion : 1:3
  7. 7. MM MM: Muscularis Mucosa
  8. 8. Surface Mucous Cells: * Simple Columnar cells with basal oval Nuclei. * Line the surface epithelium and extend to line the pits . Function: Secrete “Neutral Mucus” which forms a “thick Blanket” for lubrication & protection.
  9. 9. Fundic Stomach with a short pit Surface mucus secreting epithelium
  10. 10. Mucous Neck Cells * Located at the neck of the glands. * Low Columnar Cells with Vacuolated foamy cytoplasm. * Function: Secrete “Acidic Mucus” which protect gastric mucosa.
  11. 11. <ul><li>Found mainly in the upper parts of the gland </li></ul><ul><li>Large , rounded or triangular with central rounded nucleus. </li></ul><ul><li>DO NOT reach lumen. </li></ul><ul><li>Deeply acidophilic cytoplasm. </li></ul>OXYNTIC (PARIETAL) Cells: (Arrows) <ul><li>Functions: </li></ul><ul><li>Secretion of: </li></ul><ul><li>HCL. </li></ul><ul><li>2) Intrinsic </li></ul><ul><li>Anti-pernicious anemia Factor </li></ul>
  12. 12. Peptic (Chief) Cells: The most numerous type. Found mainly at the BASE of glands . Pyramidal cells with basal rounded nuclei. Basal basophilic cytoplasm & apical zymogen granules . <ul><li>Functions: </li></ul><ul><li>Secretion of: </li></ul><ul><li>Pepsinogen-------Pepsin </li></ul><ul><li>2) Re nn in. </li></ul><ul><li>3) Little amount of lipase . </li></ul>
  13. 15. Fundic Gastric Glands Parietal Cells
  14. 16. Musculosa of Fundus: 3 Layers Inner oblique (IO), Middle Circular (MC) and Outer Longitudinal (OL).
  15. 17. GP: Gastric Pits, MM: Muscularis Mucosa. M: Mucosa S: Submucosa. O: Inner Oblique C: Middle Circular L: Outer Longitudinal.
  16. 18. Pyloric Stomach MM – muscularis mucosa G Pits (P) are Deep, long and Wide. Pyloric Glands: <ul><li>Not Crowded, short occupy ½ thickness of mucosa . </li></ul><ul><li>Highly coiled, branched tubular. </li></ul><ul><li>Lined mainly with mucous cells . </li></ul>
  17. 19. Ratio between Pit (P): secretory Portion (G) : 1:1 P G
  18. 21. Musculosa Of Pylorus 2 Layers Inner Circular (IC) Outer Longitudinal (OL) Circular muscle is Thickened to form “ Pyloric Sphincter ” (PS ) IC OL (PS)
  19. 22. Pyloroduodenal Junction duodenum pylorus Pyloric sphincter Brunner’s glands
  20. 23. Pyloro-Duodenal Junction
  21. 24. Identify the organ (be specific). Describe the characters of the glands. (2)
  22. 25. This is a section in the fundic glands Identify the cell indicated by the arrow. (3)
  23. 26. (4) a) Identify the cell indicated by the black arrow. b) Identify the layer indicated by the red arrow. This is a section in the lower part of the fundic glands:
  24. 27. (a) (b) (5) (a) & (b) are sections in the fundus of the stomach. Identify the layer indicated by the arrow in (a) & (b).
  25. 28. (a) (b) (6) i) In slides a & b , identify the organs. ii) Identify 1, 2 & 3 in each slide.
  26. 29. (8) <ul><li>Identify the organ (be specific). </li></ul><ul><li>b) What does the black arrow point to? </li></ul><ul><li>c) Mention the type of glands pointed to by the red arrow? </li></ul>
  27. 30. 13- Identify the organ. 14- Identify the structure indicated by the arrow. 15- Identify the tissue indicated by the arrow. 16- identify the structure indicated by the arrow. 16 (9)
  28. 31. (10) a) Identify the type of junction. b) Name the abbreviations marked by the letters: S – D – PS – G- CM - LM
  29. 32. <ul><li>This is a section in the Fundus of Stomach </li></ul><ul><li>Identify the layer indicated by the arrow . </li></ul><ul><li>Identify ME. </li></ul>