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Vera Matyushenkova

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this is a Manufacturing Planning and Scheduling Techniques assignment. Case Study To complete this assignment, select one of the following engineering manufacturing businesses relevant to your engineering speciality (electrical and electronics) to refer to in your answers throughout this assignment: 1. Alloy Wheel manufacturer and distributer 2. Communication Cable manufacturer and distributer Alternatively, you can select your product or employer business as a case study and refer to in your answers.

009 manufacturing planning_and_schudiling_techniques__13-14

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"Engineering Biology to Address Global Problems: Synthetic Biology Markets, Needs, and Applications" Nancy J. Kelley, David J. Whelan, Ellyn Kerr, Aidan Apel, Robyn Beliveau, and Rachael Scanlon Nancy J. Kelley & Associates, New York, NY This Industry Report includes key findings and excerpts from the report "Synberc Sustainability Initiative: Initial Findings & Recommendations", prepared by Nancy J. Kelley & Associates, February 2014, co-funded by the Alfred P. Sloan Foundation and Synberc. The full report is available at http://bit.ly/NJKAsynbio. The information and views contained in this document are those of the authors. They do not necessarily represent the views of Industrial Biotechnology, Mary Ann Liebert, Inc., publishers, or their affiliates. Furthermore, none of the above organizations or companies, nor any persons acting on their behalf, is responsible for the use that might be made of the information contained in this publication. INDUSTRIAL BIOTECHNOLOGY JUNE 2014 DOI : 10.1089/ind.2014.1515

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Syngulon’s technology expands the capacity for selection of microorganisms. The ability to select individual microbes with a behavior of interest is essential, whether for simple cloning at the bench, or for industry-scale production. Synthetic biology uses the concept of “bioengineering” to improve or modify existing genetic systems to create microbes with desired behaviors, and Syngulon uses this approach to develop its selection technologies. This selection technology is based on bacteriocins, ribosomally-produced peptides naturally made by most bacteria to kill competitive microbial species. These bacteriocins can have a limited or wide target range against other microbial species. This technology offers advantageous over antibiotic selection for several reasons: it avoids the use of antibiotics in the first place, helping to reduce the spread of antibiotic resistant microbes. The technology also increases product yield; as bacteriocins are generally smaller peptides, they do not impose a heavy metabolic burden on the producing cell. They can have a wide target specificity, helping to avoid genetic drift. Finally, our system is 100% plasmid-based (e.g. without chromosomal mutations), making it applicable for use in any E. coli strains.

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