Project plan, antimicrobial peptide, drug discovery

1. Project Development of
Peptide-based Antimicrobial Agents
THET SU WIN
5736940 MTMT/D

2. Outline
1. Project Introduction
2. Project development process
3. Project management
4. Searching of Relevance IP
5. Expected Outcome of the project

3. Project introduction
Research Problem
Research Hypothesis
Research Purpose
Targeted Areas
1. Project Introduction

4. Antimicrobial Resistance (AMR)
 Medicines for treating infections lose effect because the
microbes change genetic information
 AMR is a natural phenomenon accelerated by use of
antimicrobial medicines.
 Resistant strains survive and aggregate.
4
Research Problem
Project Introduction

5. 5
Project Introduction
Research Problem

6.  Solution for AMR
6
Ongoing emergence of resistance worldwide continues to spur the
search for novel anti-infectives to replace and/or supplement
conventional antibiotics
Existing Antibiotics
Novel Drugs

7.  Changing trends in Drug Design
Chemistry
Natural Products
Screening
Rational Design
Molecular Biology
Biologics
(Insulin,
Growth Factors,
EPO)
Genome & Proteomics
New target
identification and
validation
Peptide Drugs
Personalized
medicine
Increased
specificity
Cheaper
manufacture
7
Activity Paramount Safety Paramount
1960 1980 2000 2020

8. Objectives
• To develop Antimicrobial Peptide as highly effective
treatment for Drug resistant microbial infections

9. Focused Therapeutic Areas
WHO Global Report on AMR (2014)

10. Drug Development Process
https://pharma.bayer.com/en/research-and-development/processes/index.php

11. 2. Project Development
Project Development
Development Process
Project Plan
Project Timeline

12. Project Development Process
Hit and Lead
Identification
Candidate
optimization
Candidate
Identification
Pre-clinical
development

13. Project Plan
Literature
review
Overall
approach and
Detail Plan
Data collection
Computational
analysis
Optimization
of Peptide
design
Laboratory
experiments
Ethical
considerations
Evaluation of
Outcome
Approach to
Future Project

14. Time Frame of Project
 3 Years Project Plan
 From July, 2015 to June, 2018

15. Project Timeline
2015 2016 2017 2018
7-9 10-12 1-3 4-6 7-9 10-12 1-3 4-6 7-9 10-12 1-3 4-6
Pre-planning
(Background
Reading)
Develop Product
Concept
Begin
Development
Cycle
Hit and lead
identification
Candidate
optimization
Candidate drug
identification
Preclinical drug
development

16. 3. Project Management
Project Management
Project Team
Monitoring and
Reporting Process
Funding Management

17. Team Organization
Principal
Investigator
Research Team 1
Bioinformatics
and Data
Mining
Research Team 2
Laboratory
Examination
Financial
Administrative
Team
Project
Development
Leader

18. • review meetings (weekly/monthly/year)
○ progress and schedule completion,
○ activities behind schedule
○ potential problems
○ Issues related to sufficient resource supply
○ delayed information
Progress monitoring and Reporting

19. Funding Management
• Finding sources of funding
– Identify relevant funding agencies
– Write a responsive proposal
– Get feedback and revise

20. Funding Management
• Research funding
– Supported by
Mahidol University
The leading research university in
Thailand with strong research expertise in
medicines, biomedical sciences, and
biotechnology.
biopharmaceuticals company
from Norway

21. Funding Management
Financial Administrative Team
Direct Costs Indirect Costs
 Personnel costs (salary, travelling
allowance)
 Equipments
 Supplies
 Other direct costs (publications,
library charges, etc)
 Training
 Accident investigation and
corrective measures
 Facilities and administrative (F&A)

22. 4. IP searching
• Patent search is the process by which
 prior inventions or ideas are examined,
 with the goal being to find information that bears
close similarity to a given patent or proposed
invention.

23. Online Patentability Search - 1
http://search.uspto.gov/search?query=antimicrobial+peptide&op=Search&affiliate=web-sdmg-uspto.gov

24. http://www.google.com/patents/US20090005300
Online Patentability Search - 2

25. Patent for AMP
http://www.freetemplateweb.com/d
ocs/108458770/Antimicrobial-
Peptides-And-Use-Thereof---Patent-

26. 5. Expected Outcome
 Prediction of potential drugable peptides with high
therapeutic index.
 Project completion within time frame
 Supportive product for next project

27. Project Summary
Problem
Identification
Observation
and
Description
Hypothesis
Experiment
Verification
New
product or
outcome
STARTPreceding to
New Project