This document describes a method for detecting low-level somatic variants in FFPE samples using Sanger sequencing and Minor Variant Finder software. It validates the method by detecting variants in 35 colon cancer FFPE samples as low as 5% allele frequency using 1 ng or less DNA input per reaction. The method provides a low-cost and fast turnaround alternative to NGS for precision oncology research applications requiring analysis of a limited number of clinically relevant targets from FFPE samples.