pharmaceutical inorganic chemistry

2. INTRODUCTION
 Iron(II) sulfate or ferrous sulfate denotes a range of salts
with the formula FeSO₄·7H₂O. These compounds exist
most commonly as the heptahydrate but are known for
several values of x. The hydrated form is used medically
to treat iron deficiency, and also for industrial
applications.
 These are the nutrients substances required for the
formulation of blood cells and used in the treatment of
anemia .

3.  Formula : FeSO4 . 7H2O
 Molar mass : 278.02
 Melting point : 70 °C
 Density : 2.84 g/cm³
 Boiling point : 330 °C
 Soluble in : Water
 People also search for : Folate, Copper(II) sulfate,

4.  It is prepared by treating slight excess of iron filings with
dilute sulphuric acid
Fe + H2SO4 = FeSO4 + H2
PROPERTIES
 It occurs as crystal as well as dry form
 Ferrous sulphate crystal occurs as bluish green crystals
or crystalline powder. It consists of seven molecules of
water of hydration.
 It is odourless and has a metallic astrigent taste.
 It is freely soluble in water and insoluble in alcohol.

5.  It forms double salt with ammonium sulphate.
FeSO4 + NH4(SO4)2 = FeSO4NH4(SO4)6H20
 It’s a reducing agent , it decolorizes acidified potassium
permanganate
2FeSO4 + 2KMnO4 + 4H2SO4
K2SO4 + 2MnSO4 + Fe(SO4 )2 + 4H2O
 It reduces mecuric chloride to mercurous chloride
2Fe2 + 2HgCl2 = Hg2Cl2 + 2Fe3 + 2Cl
 When exposed to moist air , it gets oxidized to ferric
sulphate and when heated it gets decomposed to ferric
oxide , sulphur dioxide and sulphuric acid.
2FeSO4 7H2O = Fe2O3 + SO2 + H2SO4 + 4H2O

6. IP STANDARD
 Not less than 98.0% and not more than 104.0% of
FeSO4 7H2O
ASSAY
METHOD : 1 REDOX TITRATION – CERIOMETRY
Dissolve an accurately weighted amount of substance in
water , add sulphuric acid and titrate against 0.1M cerric
ammonium sulphate using ferroinsulphate as indicator.
The end point is disappearance of red colour.
Ce4+ + Fe2+ = Ce3+ + Fe3+

7. METHOD : 1 REDOX TITRATION – CERIOMETRY
Dissolve an accurately weighted amount of substance in
sulphuric acid and titrate against 0.1M Potassium
permanganate. Potassium permanganate act as self
indicator and the end point is the appearance of
permanent pale pink colour.
2FeSO4 + 2KMnO4 + 4H2SO4
K2SO4 + 2MnSO4 + Fe(SO4 )2 + 4H2O
USES
 It is used as haematinics in the treatment of iron
deficiency anemia.

8. INTRODUCTION
Iron(II) gluconate, or ferrous gluconate, is a black
compound often used as an iron supplement. It is the
iron(II) salt of gluconic acid. It is marketed under brand
names such as Fergon, Ferralet and Simron.

9.  Formula : C12H24FeO14
 Molar mass : 448.156 g/mol
 ChemSpider ID : 19953133
 Appearance : light yellow to brown powder
 PubChem CID : 9291
 IUPAC ID : (2R,3R,4S,5S)-2,3,4,5,6-
pentahydroxyhexanoic acid, iron
 People also search for : Iron(II) sulfate , Folate
, Iron(II) fumarate ,
PREPARATION
Gluconic acid react with ferrous carbonate gives ferrous
gluconate. Further , it is crystallized with two molecule
of water of hydration
2C6H1207 + FeCO3 + H2O = Fe(C6H1107)2 2H2O + CO2

10. PROPERTIES
 It occurs as yellowish grey or pale greenish yellow
granules or powder
 It has slight odour of burnt sugar
 Slightly soluble in cold water and more soluble in hot
water
 Its aqueous solution is acidic in nature
 Its affected by light
IP LIMIT
 Not less than 95.0% and not more than 102.0%

11. ASSAY
REDOX TITRATION
Dissolve an accurately weighted amount of substance in
dilute sulphuric acid and add sodium bicarbonate ( to
produce CO2 , which prevents oxidation of ferrous to
ferric state. ) add ferroin as indicator and titrate with
0.1M cerric ammonium nitrate. The end point is
disappearance of red colour
Ce4+ + Fe2+ = Ce3+ + Fe3+
USES
 It is used as hematinic in the prevention and treatment
of iron deficiency anemia