3. Nervous System
• The nervous system can be classified into
• The Central Nervous System (CNS)
Brain and spinal cord
• The Peripheral Nervous System
(PNS (The nervous system outside of the
brain and spinal cord
4. Peripheral Nervous System PNS
Can be divided into-
1- Sensory division(affrent)
Conducts impulses from receptors to the
CNS and Informs the CNS of the state of
the body
2- Motor division(effrent)
Conducts impulses from CNS to effectors
organs.
5. Motor Neurons
• The motor division is also divided into
• 1- The somatic nervous system :
•
VOLUNTARY (generally) Somatic nerve fibers
that conduct impulses from the CNS to skeletal
muscles
• 2. The autonomic nervous system:
INVOLUNTARY (generally) Conducts impulses
from the CNS to smooth muscle, cardiac muscle,
and glands
6. Neurons
• They are the basic functional unit of the
nervous system.
• They contain three major parts:
• 1.cell body.
• 2. dendrites.
• 3. axon.
10. • Signs and symptoms:
• 1- Elevate Mood
• 2- Increase Motor Activity
• 3- Increase Alertness
• 4- Decrease need for Sleep
• In case of overdose lead to convulsion and
death.
11. MOA of CNS Stimulants
• 1- Block neurotransmitters reuptake (Most
reuptake inhibitors affect either NE or 5-
HT(Serotonin) : Cocaine
• 2- Promote neurotransmitters release :
Amphetamine
• 3- Block Metabolism - MAO inhibitors
(monoamine oxidase):ex. Phenelzine
• 4. antagonize the effect of inhibitory
neurotransmitter: Picrotoxin & Strychnine
•
14. CNS Stimulants
• - They can be divided based on their site
of action:
• 1.Cerebral stimulants (amphetamines)
• 2.Medullary stimulants (picrotoxin)
• 3.Spinal stimulants (strychnine)
15. Lab Work
• - Objectives:
• 1- To demonstrate effects of some CNS
stimulant on mice.
• 2- After the lab, you should able to handle and
inject the mice correctly.
• 3- You should able to differentiate between
amphetamine,picrotoxin and strychinine
regarding the symptoms that induced by each of
them.
16. 1- Amphetamine
• MOAs :
• Block the reuptake of norepinephrine and
dopamine into the presynaptic neuron and
increase the release of these monoamines into
the extraneuronal space.
- Clinical use:
• 1. Narcolepsy.
• 2. Attention-deficit hyperactivity disorder
17. Amphetamine
• Adverse effects:
• - Cardiovascular: Hypertension (7% to 22%, pediatric
)
• - Endocrine metabolic: Weight loss (4% to 9%,
pediatric; 11%, adults )
• - Gastrointestinal: Abdominal pain (11% to 14%,
pediatrics ), Loss of appetite (22% to 36%), Xerostomia
(35% )
• - Neurologic: Headache (26% ), Insomnia ارق (12% to
17%, pediatric; 27%, adults )
• - Psychiatric: Feeling nervous (6% )
18. Amphetamine
• After injecting, the mice with
amphetamine you well notice:
- Hair erection
• - Licking, gnawing.
• - Stereotype
• - Sniffing
19. Picrotoxin
• MOA:
• Non-competitive antagonist of GABA receptors.
• After injecting the mice with picrotoxin you
well notice:
- Clonic convulsion characterized by :
• 1. Asymmetric
• 2. Intermittent
• 3. Spontaneous
• 4. Coordinated
20. Strychinine
• MOA:
• Competitive antagonist of the glycin receptors.
• After injecting the mice with Strychinine you well
• notice:
- Tonic convulsion characterized by :
• 1. Symmetric
• 2. Reflex in origin
• 3. Continuous
• 4. Uncoordinated.