The brief summary about the Quinolones and their MOA and Uses.

1. Quinolones/Fluroquinolones
Sindhoora D
Assistant Professor
Dept.of.Pharmacology

2. Quinolones
• Synthetic
• Quinolone structure
• Primarily against gram negative bacteria
• Newer fluorinated are gram positive also
• First member are Nalidixic acid
Adverse effect:
 G.i upset and rashes frequent
 Headache, drowsiness, vertigo, visula disturbance
• Contraindicated in childrens

3. Fluroquinolones
• Containing fluorine in their structure.
• Classification:

5. Ciprofloxacin:
• Aerobic gram negative bacilli
• Rapidly absorbed in orally
Adverse effect:
• Tendinitis and tendon rupture
• Headache, dizziness and restlessness
• Skin hypersensitivity
• G.i disturbances
Uses:
• Gonorrhoea, conjunctivitis, bone,soft tissue and wound
infection, Gynaecological infection, respiratory infection,
typhoid and Bacterial gastroenteritis.

6. Norfloxacin:
• Primarily used for urinary and genital infection.
• Effective in bacterial diarrhoea.
Ofloxacin:
• Active against chlamydia and mycoplasma.
• Effective against Tuberculosis and M.leprae
• Chronic bronchitis, respiratory and ENT infection
Levofloxacin: levo isomer
• 100% bioavailibility
• Both oral and IV
• Acquired community pneumonia and exacerbation of chronic bronchitis
Gatifloxacin:
• Strep.penumoniae
Moxifloxacin:
• M.tuberculosis
• Bronchitis,sinusitis and ENT infection