Separation of Lanthanides/ Lanthanides and Actinides
Damage Of Peripheral Nerve
1.
2. ANATOMY OF THE SPINAL NERVES
• Each segmental spinal nerve is formed at or
near its intervertebral foramen by the union of
its dorsal, or sensory, root with its ventral, or
motor, root.
3. • The somatic peripheral nervous system (PNS) is defined by the presence of
Schwann cells
• This includes the primary roots, dorsal root ganglia, mixed spinal nerves,
plexuses, nerve trunks,
autonomic nervous system, and cranial nerves III through XII
4. NOTE-
A single motor neuron supplies ten
to several thousand muscle fibres
the smaller the ratio, the finer the
movement
9. NERVE INJURY & RECOVERY
Motor
Proprioception
Touch
Temperature
Pain
Sympathetic
Recovery
Injury
10. Seddon
BMJ
1942
Neurapraxia
(Transient Block)
Axonotmesis
(Lesion in Continuity)
Neurotmesis
(Division of a nerve)
Brain
1943
• Localised
degeneration of the
myelin sheaths
• Complete
interruption of axons
• Preservation of
supporting
structures (Schwann
tubes, endoneurium,
perineurium)
• All essential parts
destroyed
• Interruption can
occur without
apparent loss of
continuity
11. TRANSIENT ISCHAEMIA-
• Acute nerve compression causes numbness and tingling within 15 minutes
• loss of pain sensibility after 30 minutes and muscle weakness after 45 minutes
• Relief of compression is followed by intense paraesthesia lasting up to 5 minutes
• feeling is restored within 30 second
• TRANSIENT ENDONEURIAL ANOXIA AND THEY LEAVE NO TRACE OF NERVE DAMAGE.
12. NEURAPRAXIA
• ‘neurapraxia’ to describe a reversible block to nerve
conduction
• minor contusion or compression of a peripheral
nerve with preservation of the axis- cylinder
• Transmission of impulses is physiologically
interrupted for a time
• recovery is complete in 3-6 weeks
• Tinel’s sign-negative
13. AXONOTMESIS
• designating more significant injury
• breakdown of the axon and distal wallerian degener-ation but
with preservation of the Schwann cell and endoneurial tubes.
• Spontaneous regeneration with good functional recovery can be
expected
• Tinels sign-positive
14. NEUROTMESIS
• more severe injury
• complete anatomical severance of the nerve or extensive avulsing or
crushing injury
• Axon,Schwann cell and endoneurial tubes , eperineurium and epineurium
are disrupted to varying degrees
• significant spontaneous recovery cannot be expected.
15. IN CLINICAL PRACTICE, HOW DO YOU DISTINGUISH?
AXONOTMESIS VERSUS NEUROTMESIS
• Nature of injury
• Serial observations
• Exploration
• Imaging
16. SUNDERLAND CLASSIFICATION
Sunderland
1951 I II III IV V
Focal
Axon
+
Endoneurium
Disruption
Axon
+
Endoneurium
+
Perineurium
Disruption
Axon
+
Endoneurium
+
Perineurium
+
Epineurium
Disruption
conduction
block Axonal
Disruption
NO Wallerian
degeneration
Cross-innervation
17. • In this classification, peripheral nerve
injuries are arranged in ascending
order of severity
• Anatomically, the various degrees
represent injury to
• (1) myelin,
• (2) axon,
• (3) the endoneurial tube and its
contents,
• (4) perineurium, and
• (5) the entire nerve trunk
19. DIAGNOSIS
• NOTE-Always test for nerve injuries following any significant trauma. And test
again after manipulation or operation, in case the nerve has been damaged
during treatment!
acute chronic
20.
21. MUSCLE POWER
• Muscles supplied by the
nerve
should be tested repeatedly
• Nerve regenaration at 1mm
per day
• MOTOR MARCH
22. SENSORY EXAMINATION
• Sensory loss usually follows a
definite anatomical pattern,
• area supplied exclusively by
the severed nerve and is
called the AUTONOMOUS
ZONE
• Axonometesis –cross innervation
25. TINEL’S SIGN
• A classic sign of progressive
nerve recovery is peripheral
tingling provoked by
percussing the nerve at the
site of injury
• NOTE- where regenerating
axons are most sensitive
28. PREREQUISITES FOR NERVE REPAIR
• Skeletal stability
• Healthy tissue bed
• Healthy nerve ends
• No undue tension
• Adequate soft tissue coverage
29. FACTORS
•AgePatient factor
• Level of injury (distal vs proximal)
• Type of nerve (pure vs mixed
functions)
• Condition of nerve ends
Injury factors
• Delay to repair
• Length of gap
Surgical
factors
30. INDICATION FOR SURGERY
• Sharp injury dividing a nerve
• Blast injury
• In a closed injury when no signs of
recovery by appropriat time
31. TIME OF OPERATION
Open injury
Primary repair(6-8
hours)
Delayed primary
repair(7-18 days)
Secondary
repair(after 18 days)
Closed
injury
Conservative(splints)
Delayed intervention
32. GOOD PROGNOSTIC FACTORS
• G-growing age
• O-only motor
• O-only sensory
• D-distal lesion
• N-neuropraxia
• E-early repair
• R-radial nerve
• V-vascularity
• E-end to end repair
GOOD NERVE
34. CARE OF PARALYSED PARTS
While recovery is awaited,
• the skin must be protected from friction damage
and burns.
• The joints should be moved through their full
range twice daily to prevent stiffness and
minimize the work required of muscles when
they recover.
• SPLINTS-both dynamic and static alternatively
35. • A newly born child, delivered by full term
vaginal delivery- shoulder presentation,birth
weight-4 kg,born to a gestational diabetes
mother presented with deformity of left upper
limb,with hand held in pronation of forearm
and hand held close to the body
36.
37.
38.
39. • A patient with a past history of shoulder
dislocation,which was reduced in phc
and c/o weakness in abduction and loss
of sensory supply of lateral aspect of arm
40. • A patient came to jss hospital with c/o
inability to grip things and ride a
motor bike
• Past history of surgery to fracture of
humerus