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Nilay Tanık Argon
Department of Statistics and Operations Research
University of North Carolina
Chapel Hill, NC, USA
This research is supported by National Science Foundation Award CMMI1635574
 Relation 1:
Optimization Machine learning
 Relation 2:
Machine learning Complex decision making
Precision medicine
Public health
Healthcare operations
…
T
R
I
A
G
E

MAIN
HOSPITAL
EMERGENCY DEPARTMENT
Admission
Discharge
Triage Stage 1 Stage 2
ED work-up
Bed request
Boarding (if admit)
Total ED bed occupancy time
H
Triage Stage 1
Stage 2
H
Total ED bed occupancy time
Predict admission
and
BERT
 BERT is good:
 reduces the length-of-stay for the BERTed patient
 indirectly reduces the waiting times of consecutive
patients
 BERT is bad:
 hospital management does not like false bed
requests – waste of time/resources
 How to balance the good and the bad?
Tool 1: Estimate probability of hospital admission at
triage
Tool 2: Decide whether to BERT or not
1. Admission Prediction Tool (APT):
 Logistic regression to estimate hospital admission
probability based on info at triage (e.g. chief complaints,
sex, age)
2. Decision to BERT Tool:
 Queueing control to determine when and who to BERT.
 Threshold on the hospital admission probability
 Constant or state-dependent threshold?
General approach:
 Develop a relatively simple mathematical model
that captures the basic trade-off and solve it.
 Use the solution to the mathematical model to
develop a policy that can actually be implemented
in practice.
 Test the performance of the policy using a realistic,
validated simulation model.
Focus on a queue for a single bed
S
BeRT No BeRT
Sequential Service
Bed
Parallel Service
ED Treatment
Bed Assignment
Process
ED Treatment
Bed Assignment
Process
Service time
Service time
Waiting cost per patient per unit time
Bed assignment and preparation “cost” with BeRT
Arrival rate (Poisson process)
Mean ED service time (iid exp. dist.)
Mean bed search and preparation time (iid exp. dist.)
Prob. of admission for patient k
Bed assignment and preparation “cost” without BeRT
Admission probability
and
Server Status
Number of
patients
waiting
Objective: Minimize the long-run average cost
So, now, how do we determine the optimal threshold function,
or maybe just a “good” threshold function?
Replace with where
OR
 Challenge 1: moving from single bed queue to multi-bed ED.
 Proposed approximation: single server pooled service
capacity.
 Challenge 2: moving from stationarity to non-stationarity.
 Proposed approximation: use time-dependent estimates.
ED census, i.e., number of patients in the ED
Hospital admission probability for the patient
 Ignore ED census. BeRT if and only if
Policy parameter.
 Developed and validated a simulation model based on UNC ED
data from 2012
Wards and bed capacities at UNC ED
 Scenario created based on CDC predictions.
 18 week period with a 6-week influenza period in the middle.
Entire eighteen-week period
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
420 470 520 570 620 670
Meannumberofdailyfalse
BeRTs
Mean length of stay (min.)
CTT
FT
 Predict the most suitable unit at the hospital for the
patient who is predicted to be admitted
 Predict the total number of patients who will need a
certain type of hospital bed
Predict the ED load on the hospital for the near
future.
 More generally…
 Hospital-level load predictions to improve hospital
operations…
 Prediction:
 Internal demand for each hospital unit using data collected
from patients currently at the hospital
 External demand for each hospital unit using historical data
 Control:
 Increase supply: expedite discharges, transfer to other
hospitals/skilled nursing facilities, etc.
 Reduce/delay demand: close the hospital or parts of it to
outside transfers, divert ambulances, reschedule elective
surgeries, etc.
Machine
Learning
Operations
Research
Harvard Medical School: Wanyi Chen, PhD
UNC Statistics and Operations Research: Nilay Argon, PhD;
Yufeng Liu, PhD; Serhan Ziya, PhD
UNC School of Medicine (Emergency Medicine): Abhi Mehrotra,
MD, MBA
UNC School of Nursing: Debbie Travers, PhD, RN; Ben Linthicum,
MSN, PhD
Roundtable Analytics: Thomas Bohrmann, PhD; Kenneth Lopiano,
PhD

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2019 Triangle Machine Learning Day - Data-driven Decision Making in Healthcare Operations - Nilay Tanik Argon, September 20, 2019

  • 1. Nilay Tanık Argon Department of Statistics and Operations Research University of North Carolina Chapel Hill, NC, USA This research is supported by National Science Foundation Award CMMI1635574
  • 2.  Relation 1: Optimization Machine learning  Relation 2: Machine learning Complex decision making
  • 5. Triage Stage 1 Stage 2 ED work-up Bed request Boarding (if admit) Total ED bed occupancy time H
  • 6. Triage Stage 1 Stage 2 H Total ED bed occupancy time Predict admission and BERT
  • 7.  BERT is good:  reduces the length-of-stay for the BERTed patient  indirectly reduces the waiting times of consecutive patients  BERT is bad:  hospital management does not like false bed requests – waste of time/resources  How to balance the good and the bad?
  • 8. Tool 1: Estimate probability of hospital admission at triage Tool 2: Decide whether to BERT or not
  • 9. 1. Admission Prediction Tool (APT):  Logistic regression to estimate hospital admission probability based on info at triage (e.g. chief complaints, sex, age) 2. Decision to BERT Tool:  Queueing control to determine when and who to BERT.  Threshold on the hospital admission probability  Constant or state-dependent threshold?
  • 10. General approach:  Develop a relatively simple mathematical model that captures the basic trade-off and solve it.  Use the solution to the mathematical model to develop a policy that can actually be implemented in practice.  Test the performance of the policy using a realistic, validated simulation model.
  • 11. Focus on a queue for a single bed S BeRT No BeRT Sequential Service Bed Parallel Service ED Treatment Bed Assignment Process ED Treatment Bed Assignment Process Service time Service time
  • 12. Waiting cost per patient per unit time Bed assignment and preparation “cost” with BeRT Arrival rate (Poisson process) Mean ED service time (iid exp. dist.) Mean bed search and preparation time (iid exp. dist.) Prob. of admission for patient k Bed assignment and preparation “cost” without BeRT
  • 13. Admission probability and Server Status Number of patients waiting Objective: Minimize the long-run average cost
  • 14.
  • 15.
  • 16. So, now, how do we determine the optimal threshold function, or maybe just a “good” threshold function?
  • 17.
  • 18.
  • 20.  Challenge 1: moving from single bed queue to multi-bed ED.  Proposed approximation: single server pooled service capacity.  Challenge 2: moving from stationarity to non-stationarity.  Proposed approximation: use time-dependent estimates.
  • 21. ED census, i.e., number of patients in the ED Hospital admission probability for the patient
  • 22.  Ignore ED census. BeRT if and only if Policy parameter.
  • 23.  Developed and validated a simulation model based on UNC ED data from 2012 Wards and bed capacities at UNC ED
  • 24.
  • 25.
  • 26.  Scenario created based on CDC predictions.  18 week period with a 6-week influenza period in the middle.
  • 27. Entire eighteen-week period 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 420 470 520 570 620 670 Meannumberofdailyfalse BeRTs Mean length of stay (min.) CTT FT
  • 28.  Predict the most suitable unit at the hospital for the patient who is predicted to be admitted  Predict the total number of patients who will need a certain type of hospital bed Predict the ED load on the hospital for the near future.  More generally…  Hospital-level load predictions to improve hospital operations…
  • 29.
  • 30.  Prediction:  Internal demand for each hospital unit using data collected from patients currently at the hospital  External demand for each hospital unit using historical data  Control:  Increase supply: expedite discharges, transfer to other hospitals/skilled nursing facilities, etc.  Reduce/delay demand: close the hospital or parts of it to outside transfers, divert ambulances, reschedule elective surgeries, etc. Machine Learning Operations Research
  • 31. Harvard Medical School: Wanyi Chen, PhD UNC Statistics and Operations Research: Nilay Argon, PhD; Yufeng Liu, PhD; Serhan Ziya, PhD UNC School of Medicine (Emergency Medicine): Abhi Mehrotra, MD, MBA UNC School of Nursing: Debbie Travers, PhD, RN; Ben Linthicum, MSN, PhD Roundtable Analytics: Thomas Bohrmann, PhD; Kenneth Lopiano, PhD