2. Gastrointestinal Agents or GIT tract
➢ One of the Vital organ Present in the body.
➢ Responsible for;
1. Consuming and digesting foodstuffs,
2. Absorbing nutrients and expelling waste.
➢ Effected by Enzymatic breakdown of complex food molecules into;
âž” Monosaccharides, Amino acids and glycerides.
➢ Dysfunction of any one of the GIT system → Human illness
➢ The tract consists of the stomach and intestines, and is divided into the upper and lower
Gastrointestinal tracts.
3. GIT AGENTS
Agents used to treat gastrointestinal disturbance are known as gastrointestinal agents.
For the treatment of gastrointestinal disorder of more serious conditions, the various inorganic
agents used to treat GIT disorders include/ classififed as:
1. Acidifying agents and antacids → Products for altering gastric pH
2. Protectives → intestinal inflammation
3. Adsorbents → intestinal toxins
4. Saline cathartics or laxatives → constipation
5. ACIDIFYING AGENTS
• In Digestion of Food → important constituent of gastric juice are PEPSIN (proteolytic enzyme) and Hydrochloric
acid (Hcl)
• Always there is a small quantity of gastric juice present in stomach, even it contains no food → Fasting juice
• Pepsin → most effective in acidic environment (pH 2.0) and becomes inactive at higher pH (alkaline)
• Hydrochloric acid present in gastric juice acts as;
➢ Acidifies food and stops the action of ptyalin
➢ Kills microbes which acts against to our body
➢ Provides acid environment needed for effective digestion by pepsin
• Pepsinogens → activated to pepsin by Hcl
6. HCL
Secreted By Oxyntic (parietal) Cells
Secretion under the control of;
Acetylcholine Histamine Gastrin
9. PARIETAL CELLS (Oxyntic Cells)
➢Are Epithelial Cells
➢ Secrete Hydrochloric Acid (Hcl) And Intrinsic Factor.
➢Located In The Gastric Glands
➢Found In Lining Of The Fundus And Body Regions Of The Stomach.
LINK → HTTPS://YOUTU.BE/ZADJ0K0WAFY
BILE CANALICULUS (Bile Capillaries)
➢Is A Thin Tube That Collects Bile Secreted By Hepatocytes.
➢Bile Canaliculi Empty Into A Series Of Progressively
➢ Larger Bile Ductules And Ducts,
➢Which Eventually Become Common Hepatic Duct
10. ACHLORHYDRIA
Patients Suffering From Achlorhydria
1. Respond to stimulation by Histamine phosphate
• ( Release of gastric acid Increases)
2. Lack of gastric HCl even after stimulation of Hp
• 10% w/w Dil.HCl recommended to releive from achlorhydria
• Note→ Hypochlorhydria – low gastric acid content
11.
12. DEFINITION
• Chemical Substances Which Remove The Excess Acid And Raise the pH To An Appropriate
Level In Stomach Are Called “Antacid”.
• Antacids Are the Drugs acts as a basic salt Used To Neutralize the Hydrochloric Acid Secreted in
the Stomach In Gastric Juice.
• They raise the pH of the gastric contents to above 3.5 and give the symptomatic relief of pain
( in gastric and duodenal ulcers )
• By lowering the acidity and consequently relieving the muscle spasm.
• They do this by acting as weak bases
13. ANTACID COMPOUNDS
Antacids are weak bases → used to neutralize excess stomach acid
Most antacids are weak inorganic bases
Common examples include;
1. SODIUM BICARBONATE
2. ALUMINIUM HYDROXIDE GEL
3. ALUMINIUM PHOSPHATE
4. CALCIUM CARBONATE
5. MAGNESIUM CARBONATE
6. MAGNESIUM TRISILICATE
7. MAGNESIUM OXIDE AND COMBINATION OF ANTACID PREPARATIONS
14. REACTION OF ANTACID
ď‚— Antacids react with HCl in the stomach
ď‚— Some common antacid reactions include:
CaCO3 + 2 HCl → CaCl2 + H2O + CO2
NaHCO3 + HCl → NaCl + H2O + CO2
Al(OH)3 + 3 HCl → AlCl3 + 3 H2O
Mg(OH)2 + 2 HCl → MgCl2 + 2 H2O
MgO + 2 HCl → MgCl2 + H2O
15. MECHANISM OF ANTACID
• Antacids perform a neutralization reaction, in the stomach and by inhibiting pepsin, which is a proteolytic
enzyme.
• They buffer gastric acid, raising the pH to reduce acidity in the stomach.
• When gastric hydrochloric acid reaches the nerves in the gastrointestinal mucosa, they signal pain to the central
nervous system. This happens when these nerves are exposed, as in peptic ulcers.
• The gastric acid may also reach ulcers in the esophagus or the duodenum.
• Link → https://youtu.be/d3X0gurRdhg
20. SOME FAMOUS BRANDS OF ANTACIDS
1. ALKA-SELTZER – NAHCO3 AND/OR KHCO3
2. EQUATE –AL(OH)3 AND MG(OH)2
3. GAVISCON –AL(OH)3
4. MAALOX (LIQUID) –AL(OH)3 AND MG(OH)2
5. MAALOX (TABLET) – CACO3
6. MILK OF MAGNESIA – MG(OH)2
7. PEPTO-BISMOL – HOC6H4COO
8. PEPTO-BISMOL CHILDREN’S – CACO3
9. ROLAIDS – CACO3 AND MG(OH)2
10. TUMS – CACO3
11. MYLANTA
21. USES OF ANTACIDS
ď‚— It Bring Down the Percentage Of Acidity In Our Stomach And Prevent Mucus Lining In The
Stomach.
ď‚— It Prevent From Heart Burn (Acid From Stomach Rising Into Esophagus) that Can To Our Stomach
Lining.
ď‚— It Also Prevent From The Ulcer (damage To Lining Of Stomach Wall, Resulting In Loss Of Tissues
And Inflammation).
22. SIDE EFFECTS
ď‚— Magnesium Compounds May Cause Diarrhea
ď‚— Aluminum Compounds May Cause Constipation And They Also May Interfere With The
Adsorption Of Phosphates In The Formation Of Bones. This Is More Likely To Be True If They
Are Taken For An Extended Period Of Time
ď‚— Carbonates May Generate Carbon Dioxide Leading To Bloating And Flatulence.
ď‚— Calcium Compounds Containing MayAlso Increase Calcium Output In The Urine, Which
Might Be Associated With KidneyStones.
ď‚— Sodium : Increased Intake Of Sodium May Be Deleterious ForArterial Hypertension,
Heart Failure And Many Renal Diseases.
23. WHO CANNOT TAKE ANTACID
• Patient With Kidney Failure Or Heart Burn Diseases Sodium Bicarbonate Has High Sodium
Content And Is Not Appropriate For People Who Are On Salt Restricted Diet Or Have
Congestive Heart Failure High Blood Pressure Or Kidney Problem .In Pregnant If A Lady Is
Pregnant Antacid Are Safetous For Heart Burn Symptoms But Do Not UseAntacid.
24. INDICATIONS WHEN WE TAKE ANTACID
ď‚— When Heart Burn Is There Then We Take Antacid To Reduce The Heartburn.
ď‚— Treatment With Antacids Alone Is Symptomatic And Only Justified For Minor Symptoms.
ď‚— The Utility Of Many Combinations Of Antacids Is Not Clear, Although The Combination Of
Magnesium And Aluminium Salts May Prevent Alteration Of Bowel Habits.
ď‚— ATypical Feeling Of Restlessness.
ď‚— Indigestion.
ď‚— Feeling Of Nausea (Wanting To Throw Up) And Actual Vomiting.
25. CLASSIFICATION OF ANTACIDS
Non-
systemic
• Directly neutralize the acid in stomach and give
relief to gastric and duodenal ulcers.
Aluminum hydroxide gel,
Aluminum Magnesium carbonate,
Magnesium phosphate & trisilicate,
Calcium carbonate
Magnesium oxide
Systemic
• Absorbed from gut into blood circulation → cause alkalosis.
• Also called systemic alkalisers
• Injection to relieve acidosis in blood, especially diabetic coma
Sodium bicarbonate
26. COMBINATION OF ANTACID
• 3 complications are seen, when antacids used;
1. Exerts an action on the bowel with some mild laxative (MgOH) & constipation Al(OH)3 effect
2. If the Cation (metallic ion) is absorbed →systemic alkalosis (NaHCO3) produced
3. Calcium ions → hypercalcemia & mg and Al → precipitation of PO4 in GIT and Phosphorous gets
depleted
4. Affects the absorption of other drugs which are administered along with antacids such as
anticholinergics and antibiotics, due to its adsorption by antacids → alter pH and delays absorption
5. Dyspepsia → gas formation in gut – use of methylpolysiloxane ( dimethicone / simethicone )
necessary.
6. In order to minimize this defects → combination of antacids are to be used
(MgOH) + Al(OH)3 combination → Balancing the laxative and constipation effect
27. ANTACID COMBINATIONS IN CLINICAL USE
Magnesium And Aluminium
Hydroxide ( Magaldrate )
Magnesium And Aluminium
Hydroxide, Dimethicone ( Dioval
Forte Tablets )
Magnesium And Aluminium Hydroxide,
Methylpolysiloxane (Gelusil Mps)
Aluminium Hydroxide Gel And
Magnesium Trisilicate (Gelusil)
Aluminium Hydroxide Gel,
Magnesium Hydroxide And
Magnesium Trisilicate (Gelusil M)
Magnesium And Aluminium
Hydroxide, Methylpolysiloxane,
sodium Carboxy Methyl Cellulose
(Digene Gel)
28. SYSTEMIC ANTACIDS
1. SODIUM BICARBONATE (NaHCO3)
âť‘ Synonym : Baking soda
âť‘ Molecular Formula : NaHCO3
âť‘ Molecular weight : 84.01 gm
âť‘ Category : Antacid
❑ Standard : It contains 99 – 100.5 % equivalent of sodium bicarbonate calculated with reference to
dried compound.
âť‘ Preparation : LABORATORY METHOD
I) It is prepared by passing CO2 gas through NaOH solution
2 NaOH + CO2
Na2CO3 + H2O
Sodium hydroxide carbondioxide sodium carbonate water
29. II) Further, Addition Of CO2 Produces Sodium Bicarbonate Will Precipitate Out Of Solution
âť‘INDUSTRIAL METHOD
➢SOLVAY PROCESS
âś“Brine Solution (Nacl) Is Saturated With Ammonia (To Remove Impurities).
âś“The Solution Is Filtered, CO2 Is Passed Through The Solution.
✓Precipitate → Filtered And Dried.
Na2CO3 + H2O + CO2 2NaHCO 3
sodium carbonate water carbondioxide Sodium bicarbonate
H2O + CO2 → H2CO3
NH3 + H2CO3 → NH4HCO3
NaCl + NH4HCO3 → NaHCO3 + NH4Cl
30. âť‘Physical properties:
âś“Its is a white, odourless and crystalline powder
âś“Stable in dry air and Saline Taste.
✓In moist air → decomposes to sod.co3, water, co2
âś“Soluble in water
âś“Insoluble in alcohol
âť‘ Chemical Properties:
1. When heated with water → loses water and carbondioxide and forms carbonate
31. 2. CO2 is again liberated when it is heated with any acid
3.Reacts with mercury chloride → forms Reddish brown precipitate of mercury oxide (HgO)
NaHCO3 + HCl = NaCl + H2O + CO2
Sodium bicarbonate Hydrochloric acid Sodium chloride water Carbondioxide
HgCl2 + 2NaHCO3 Hg(HCO3)2 + 2NaCl
Hg(HCO3)2
HgO + H2O + CO2
Mercury chloride Sodium bicarbonate Mercury bicarbonate Sodium chloride
Mercury bicarbonate Mercury oxide Water Carbondioxide
32. âť‘ Test For Identity:
Solution of a substance + CO2 free water + Phenolphthalein
Pale pink colour is produced ( due to alkalinity of NaHCO3 )
On heating
Evolution of CO2 gas
Solution becomes Red ( due to formation of Na2CO3 )
33. âť‘ Test For Purity:
âś“ Arsenic
âś“ Calcium
âś“ Heavy metals
âś“ Chloride
âś“ Sulphate
âť‘ Assay :
Acid - base titration
Weighed amount is dissolved in water + titrated with sulphuric acid using methyl orange as indicator.
2NaHCO3 + H2SO4 → Na2 SO4 + 2CO2 + 2H2O
âť‘Storage condition :
✓ It should be stored in a well –closed container.
âś“ Since, it slowly decomposed when exposed to moist air
34. âť‘Dosage:
1 to 4 gm per day
âť‘Medicinal And Pharmaceutical Uses:
âś“Used As An Antacid
âś“Used In Systemic Acidosis, Especially In Diabetic Coma
âś“Used As A Electrolyte Replinisher
âś“Used As Local Application For Burns, Insect Bites Etc.
âś“Used As A Constituent In Ear Drops To Soften And Remove Wax.
35. NON - SYSTEMIC ANTACIDS
1. ALUMINIUM HYDROXIDE GEL
âť‘Description:
âś“It is an aqueous suspension of hydrated aluminium oxide together with varying amounts of basic
aluminium carbonate.
âś“It contains aluminium oxide, glycerin, sucrose or saccharin as a sweetening agent, peppermint oil as a
flavouring agent and sodium benzoate as a preservative.
âť‘Synonym : Aluminic acid
âť‘ Molecular Formula : Al(OH)3
âť‘ Molecular weight : 78 gm
âť‘ Category : Antacid
âť‘ Standard : It contains not less than 3.5 % and not more than 4.4 % w/w Al2O3
36. âť‘ Preparation :
1. Prepared by the reaction of an aluminium sulphate or aluminium chloride with sodium carbonate or
sodium bicarbonate.
2. The precipitate of aluminium hydroxide is collected, washed and resuspended in water and finally
homogenized.
3Na2 CO3 + 3H2O → 3NaHCO3 + 3 NaOH
Alcl3 + 3NaOH + H2O → 3 NaCl + Al(OH)3. 3H2O
2NaHCO3 → Na2CO3 + H2O + CO2
38. âť‘Physical Properties :
1. It is a white viscous suspension.
2. A clear liquid gets separated when it is kept standing for sometime.
3. pH between 5.5 to 8.0
4. Amphoteric in nature and
5. Dissolves readily in acids or alkalis → forming aluminium salts and aluminates
âť‘Chemical properties:
❑When heated strongly → decomposes into Aluminium oxide and water
❑It reacts with HCl → forms Aluminium Chloride
Al(OH)3 + 3HCl = AlCl3 + 3H2O
39. âť‘Assay:
Complexometric titration
âť‘Test for Purity
âś“ pH
âś“ Arsenic
âś“ Heavy metals
âś“ Chloride
âś“ Sulphate
âť‘Storage
Stored in a tightly closed container in a cool place. Avoid freezing.
âť‘Uses:
1. As an antacid.
2. Since aluminium salts produce constipation, and are therefore generally administered along with magnesium salts
to counteract this effect.
3. Used in cases of acute hyper acidity
4. Acts as a Protective in treating Peptic ulcers.
40. 1. DRIED ALUMINIUM HYDROXIDE GEL
âť‘ Synonym : Aluminic acid
âť‘ Molecular Formula : Al(OH)3
âť‘ Molecular weight : 78 gm
âť‘ Category : Antacid
âť‘ Standard : It contains not less than 47% and not more than 60% of Al2O3
âť‘Properties:
âś“White, light, amorphous powder
âś“Odourless and tasteless
âś“Consists of;
1. hydrated aluminium oxide
2. small quantities of basic aluminium carbonate and bicarbonate
âś“Insoluble in water and alcohol
âś“Soluble in mineral acids
41. âť‘Chemical properties:
❑When heated strongly → decomposes into Aluminium oxide and water
❑It reacts with HCl → forms Aluminium Chloride
Al(OH)3 + 3HCl = AlCl3 + 3H2O
âť‘Assay:
Complexometric titration
âť‘Test for Purity
âś“ pH
âś“ Arsenic
âś“ Heavy metals
âś“ Chloride
âś“ Sulphate
âť‘Storage
Stored in a tightly closed container
42. âť‘Medicinal and Pharmaceutical Uses:
1. As an antacid.
2. Used in cases of acute hyper acidity
3. Acts as a Protective in treating Peptic ulcers.
4. Since aluminium salts produce constipation, and are therefore generally administered along with
magnesium salts to counteract this effect.
43. 3. ALUMINIUM PHOSPHATE ( AlPO4)
âť‘Synonym : Dried aluminum phosphate gel
âť‘ Molecular Formula : AlPO4
âť‘ Molecular weight : 122 gm
âť‘ Category : Antacid
âť‘ Standard : It consists mainly 80% of hydrated aluminium ortho phosphate (AlPO4).
âť‘ Preparation :
1. By interaction between aqueous Aluminium chloride and sodium phosphate
AlCl3 + Na3PO4 AlPO4 + 3NaCl
45. 2. Solution of dried dibasic sodium phosphate in water is added slowly to solution of AlCl3 → AlPO4 is formed
along with NaCl and HCl
3. HCl formed is neutralized by adding diluted ammonia.
Mixture is filtered and washed with water to free it from soluble salts
Sufficient water is added to get a gel with Con. About 4% AlPO4
All the water is removed and product gets dried under suitable condition
To get a dried ALPO4
AlCl3.6H2O + Na2HPO4 = AlPO4 + 2NaCl + HCl + 6H2O
HCl + NH4OH = NH4Cl + H2O
46. âť‘ Physical Properties :
1. It is a white powder or suspension having friable aggregates.
2. Insoluble in ethanol, water, NaOH solutions
3. Soluble in Dilute mineral acids
3. Gel → pH between 6.0 to 7.2
âť‘ Chemical properties:
âť‘ Undergoes Acid neutralizing capacity is based on the release of trivalent phosphate ion due to its
Strongly basic nature
AlPO4 Al+3 + PO4
-3
47. âť‘Assay:
Complexometric titration
❑ Dosage: 5 – 15 ml ( 1 teaspoonful – 1 tablespoon )
âť‘Test for Purity
âś“Acidity and alkalinity
âś“Arsenic
âś“Heavy metals
âś“Phosphate
âť‘ Storage
Stored in a well closed container
48. âť‘ Medicinal and Pharmaceutical Uses:
âś“Used as a Mild slow acting antacid having half the acid neutralising capacity of aluminium
hydroxide gel
✓It is better than aluminium hydroxide gel in the sense that it doesn’t interfere with the absorption
of phosphates from the intestine
49. 4. CALCIUM CARBONATE (CaCO3)
âť‘Synonym : Precipitated Chalk
âť‘ Molecular Formula : CaCO3
âť‘ Molecular weight : 100 gm
âť‘ Category : Antacid
âť‘ Standard : It contains not less than 98% and not more than 100.5% CaCO3
âť‘ Preparation :
1. Prepared by mixing solution of calcium chloride and sodium carbonate
CaCl2 + Na2CO3 CaCO3 + 2NaCl
51. 2. Prepared by passing CO2 through lime water
âť‘Physical Properties :
1. It is a white, odourless, tasteless microcrystalline powder
2. Insoluble water and slightly soluble in water containing CO2.
3. In Soluble in alcohol and soluble in some acids
4. Stable in Air
Ca(OH)2 + CO2 CaCO3 + H2O
Calcium hydroxide Carbondioxide Calcium carbonate
53. âť‘Chemical properties:
It decomposes back to CaO and CO2 when heated beyond 830c. Its solubility is enhanced in presence of CO2
âť‘Assay :
Complexometric titration
âť‘Test for Purity:
âś“ Arsenic
âś“ Heavy metals
âś“ Chloride
âś“ Sulphide
âś“ Barium
CaCO3 + H2O + CO2 Ca(HCO3)2
CALCIUM CARBONATE CARBONDIOXIDE CALCIUM BICARBONATE
54. âť‘Storage:
Is stable in air, it may be stored in a well closed container.
âť‘Medicinal and Pharmaceutical Uses
âś“ Used as fast acting non-systemic antacid
âś“ As a supplement for calcium deficiency
âś“ As Dentrifices due to mild abrasive property and in cosmetics
âś“ As a precipitated chalk used in Tooth powder.
âś“ Also used in treatment of some forms of diarrhoea, due to its non-irritating nature.
✓ Limestone → used in manufacture of cement, lime, washing soda and glass.
55. 5. MAGNESIUM CARBONATE (MgCO3)
(Heavy and light magnesium carbonate)
âť‘Synonym : Mineral magnesite
âť‘ Molecular Formula : MgCO3.Mg(OH)2.5H2O (Heavy) OR MgCO3.Mg(OH)2.3H2O (light)
âť‘ Molecular weight : 485 gm
âť‘ Category : Laxative
âť‘ Standard : It is hydrated basic MgCO3 containing 40-45% MgO
âť‘ Preparation :
1. Is prepared by mixing hot solutions of MgSO4 and sodium carbonate
MgSO4 + Na2CO3 MgCO3 + Na2SO4
56. 2. Is Precipitated by the addition of sodium carbonate to an aqueous solution of a Mg salt and saturating it
with CO2
MgCl2 + 2NaHCO3 + CO2 + H2O MgCO3 2NaCl + 2H2CO3
Heavy magnesium carbonate - MgCO3.Mg(OH)2.5H2O (40- 45% OF CaO)
Hot solutions of
Magnesium sulphate (125 parts) + Sodium carbonate (150 parts) in Water (250 parts)
Mixed
Evaporated → dryness
Dried Residue → treated with water
Insoluble carbonate is filtered
Washed and dried in oven
57. Light magnesium carbonate - MgCO3.Mg(OH)2.3H2O (40- 45% OF CaO)
Mixing solutions of
Magnesium sulphate (125 parts) + Sodium carbonate (150 parts) in Water (1000 parts)
Mixed
Boiled for 15 Minutes
Precipitate is obtained
filtered
Washed and dried in oven
59. âť‘Physical Properties : (Heavy & Light MgCO3)
1. Hydrated MgCO3 → contains 40-45 % of MgO
2. White, odourless powder or light, white and friable masses
3. In Soluble in water and alcohol but dissolve in dilute acids
4. Stable in Air
âť‘Chemical properties:
1. It reacts with dilute acids → strong effervescence. At 7000C, converted into MgO
MgCO3 MgO + CO2
60. 2. When heated to redness → give MgO
3[MgCO3.Mg(OH)2.5H2O] 4MgO + 3CO2 + 6H2O
âť‘Assay :
Complexometric titration
âť‘Test for Purity:
âś“Arsenic
âś“Heavy metals
âś“Chloride
âś“Sulphide
âś“Copper and Lead
61. âť‘Storage:
Stored in a well closed container.
âť‘Medicinal and Pharmaceutical Uses
âś“Used as a Cathartic and laxative
âś“Also used in food additive, in tooth and face powders
âś“Used as a mild non-systemic Antacid
62. 6. MAGNESIUM TRISILICATE
âť‘Synonym : Epsom salt, Hydrated magnesium silicate
âť‘ Molecular Formula : 2MgO.3SiO2.3H2O
âť‘ Molecular weight : 261 gm
âť‘ Category : Adsorbent and Antacid
âť‘ Standard : It is hydrated basic MgCO3 containing 40-45% MgO
âť‘ Preparation :
1. Is prepared by mixing hot solutions of MgSO4 and sodium carbonate
2MgSO4 + 4NaSiO2 + excess 3H2O 2MgO.3SiO2.3H2O + 2Na2SO4 + SiO2
64. âť‘Physical Properties :
1. Odourless, tasteless, white grainy powder
2. Slightly hygroscopic in nature
3. Insoluble in water and alcohol
âť‘Chemical Properties :
1. When Treated With any acid such as dil.HCl → forms MgCl2 and gelatinous trisilicic
acid
Mg2Si3O8 + 4HCl = 2MgCl2 + H4Si3O8
Magnesium trisilicate Trisilicic acid
65. 2. It neutralises gastric acid
MgO + 2H3O Mg(OH)2 + 2H2O
MgO + 2HCl MgCl2 + H2O
âť‘Assay :
Complexometric titration
âť‘Test for Purity:
âś“Arsenic
âś“Heavy metals
âś“Chloride
âś“Sulphide
âś“Copper and Lead
66. âť‘Dose:
I gm four times a day
âť‘Storage:
Stored in a well closed container.
âť‘Medicinal and Pharmaceutical Uses
âś“ Used as an antacid and adsorbent.
âś“ Reduces gastric pain and hyperacidity
âś“ Used in larger doses to induce diarrhoea
âś“ Due to presence of Silicon dioxide, it acts as a protectant for gastric mucosa in ulcers.
67. 7. MAGNESIUM OXIDE (MgO)
âť‘Synonym : Magnesia
âť‘ Molecular Formula : MgO
âť‘ Molecular weight : 40 gm
âť‘ Category : Osmotic laxative and dentrifice
âť‘ Standard : Not less than 98 % MgO
âť‘ Preparation :
1. Is prepared by gently heating the magnesium carbonate
MgCO3 MgO + CO2
2. When light carbonate is heated → redness, MgO is formed
3MgCO3. Mg(OH).3H2O 4MgO + 3CO2 +4H2O
68. âť‘Physical Properties :
1. Very light, bulky, white powder→ light MgO, Dense mass → heavy MgO
2. Odourless, slightly alkaline taste
3. Practically insoluble in water
4. Dissolve with dilute acids → slight effervescence
5. When exposed to air → absorbs moisture and CO2
69. âť‘Chemical Properties :
1. Is soluble in carbonic acid solution
MgO + H2O + 2CO2 Mg+2 + 2HCO-3
2. At high temperatures, it reacts with carbon to form Magnesium carbide
CaC2 + MgO MgC + CaO + C
3. MgO reacts with acid → form salts
MgO + 2HCl MgCl2 + H2O
âť‘Assay :
Complexometric titration
70. âť‘Test for Purity:
âś“Arsenic
âś“Heavy metals
âś“Iron
âś“Sulphide
âś“Copper and Lead
âť‘Storage:
Stored in a well closed container.
âť‘Medicinal and Pharmaceutical Uses
• Antacid And Osmotic Laxative
• Used As An Dentrifice And Food Additives
71. COMBINATION OF ANTACID PREPARATIONS
• COMBINATIONS OFANTACID
• PREPARATIONS
• ANTACID PREPARATIONS ARE FORMULATED WITH ONE MORE THAN ONE ANTACID AS COMBINATIONS TO
COUNTERACT THE SIDE EFFECT OF ONE BY ANOTHER OR TO BE USED FOR SPECIFIC CONDITIONS.
• (I) ALUMINIUM HYDROXIDE GEL – MAGNESIUM HYDROXIDE COMBINATION.
• PREPARATION: AVAILABLE AS ORAL SUSPENSION AND TABLETS.
• ADV: SINCE ALUMINIUM SALTS CAUSES CONSTIPATION, THIS EFFECT IS BALANCED BY LAXATIVE EFFECT OF
MAGNESIUM.
• (II) SIMETHICONE CONTAINING ANTACIDS
• IT IS FORMULATED ALONG WITH ALUMINIUM HYDROXIDE GEL AND MAGNESIUM HYDROXIDE.
• IT IS AVAILABLE AS ORAL SUSPENSION AND TABLET.
• ADVANTAGE: SIMETHICONE RELIEVES FLATULENCE.
• (III) ALUMINIUM HYDROXIDE GEL – MAGNESIUM TRISILICATE COMBINATION
• IT IS AVAILABLE AS ORAL SUSPENSION AND TABLET.
• ADVANTAGE:
• MAGNESIUM TRISILICATE HAS PROTECTIVE EFFECT.
72. Magnesium And Aluminium
Hydroxide ( Magaldrate )
Magnesium And Aluminium
Hydroxide, Dimethicone ( Dioval
Forte Tablets )
Magnesium And Aluminium Hydroxide,
Methylpolysiloxane (Gelusil Mps)
Aluminium Hydroxide Gel And
Magnesium Trisilicate (Gelusil)
Aluminium Hydroxide Gel, Magnesium
Hydroxide And Magnesium Trisilicate
(Gelusil M)
Magnesium And Aluminium Hydroxide,
Methylpolysiloxane, sodium Carboxy
Methyl Cellulose (Digene Gel)
73. Magnesium And Aluminium Hydroxide
( Magaldrate )
Magaldrate → product of chemical combination of aluminium hydroxide and magnesium
hydroxide along with the sulphates of aluminium and magnesium
âť‘Synonym : MAGALDRATUM
âť‘ Molecular Formula : Al5Mg10(OH)31(SO4)2,xH2O
âť‘ Molecular weight : 164 gm
âť‘ Category : Antacid
âť‘ Standard : Not more than 100.5 % and Not less than 90 % Al5Mg10(OH)31(SO4)2,xH2O
âť‘Assay: Potentiometric titration
74. âť‘Physical Properties :
1. White , crystalline powder
2. Odourless, slightly alkaline taste
3. Practically insoluble in water and water
4. Dissolve with dilute acids
âť‘Test for Purity:
âś“ Arsenic
âś“ Heavy metals
âś“ Iron
âś“ Sulphide
âś“ Copper and Lead
75. âť‘Storage:
Stored in a well closed container.
âť‘Medicinal and Pharmaceutical Uses
• Antacid
• Magaldrate used in the formulation of magaldrate oral suspension and oral tablet