2. Introduction -
Antenatal diagnosis
of pregnancy
include –
1. Presumptive signs
2. Probable signs
3. Positive signs
3.
4.
5.
6.
7.
8. FIRST TRIMESTER(FIRST 12
WEEKS)
A. SUBJECTIVE SYMPTOMS -
AMENORRHOEA
MORNING SICKNESS(FIRST
TRIMESTER)
FREQUENCY OF MICTURATION(8-12
WKS)
BREAST DISCOMFORT ( 6-8 WKS )
9. B. OBJECTIVE SIGN
1. BREAST CHANGES (6-8WEEKS)
Breast enlargement with vascular
engorgement.
Nipple and areola become more
pigmented.
Colostrum can be expressed as
early as 12th week.
Montgomery’s tubercles are
10.
11. 2. PELVIC CHANGES -
JACQUEMIER’S SIGN (8WKS)
OSIANDER SIGN
GOODELL’S SIGN
UTERINE SIGN
HEGAR’S SIGN
Uterus remains a pelvic organ
until 12th week, then it may be felt
per abdomen as a suprapubic
12. i. CHADWICK’S SIGN -
ON SPECULUM INSPECTION –
CERVIX & VAGINA APPEAR
BLUISH OR PURPLISH
DISCOLORATION DUE TO
VASCULAR CONGESTION AT
ABOUT 8TH WEEK OF
PREGNANCY.
13. ii. OSIANDER’S SIGN ( vaginal
signs )
BLUISH DISCOLOURATION OF THE
ANTERIOR VAGINAL WALL
COPIUS NON IRRITATING MUCOID
DISCHARGE APPEARS AT 6TH WEEK
INCREASE PULSATION FELT THROUGH
THE LATERAL FORNICES AT 8TH WK.
15. iv. UTERINE SIGN -
HEN’S EGG 6TH WK
CRICKET BALL 8TH WK
FETAL HEAD 12 WK
SHAPE – BECOMES GLOBULAR AT 12
WKS FROM PYRIFORM.
CONSISTENCY – BECOMES SOFT &
ELASTIC.
16. v. HEGAR’S SIGN
(6-8WKS)
UPPER PART OF
THE BODY OF THE
UTERUS IS
ENLARGED BY
THE GROWING OVUM
LOWER PART OF
THE BODY IS EMPTY
AND EXTREMELY SOFT.
CERVIX IS COMPARATIVELY FIRM.
18. PREGNANCY TEST
SUMMARY OF PREGNANCY TEST
TEST SENSITIVIT
Y HCG
(IU/ML)
TIME
TAKEN
INFERENCE POSITIVE ON
IMMUNOLOGICAL TEST
SLIDE TEST
1.5-3.5 2MIN NO AGGLUTINATION 42 DAYS AFTER LMP
BETA GRAVINDEX SLIDE
TEST
0.5-1 2MIN ABSENCE OF
AGGLUTINATION
2 DAYS AFTER MISSED
PERIODS
PREG COLOR TEST 1.5-2 0MIN TURNS COLOURLESS 2 DAYS AFTER MISSED
PERIODS
DIRECT LATEX
AGGLUTINATION TEST
0.2 2MIN PRESENCE OF
AGGLUTINATION
2 -3DAYS AFTER MISSED
PERIODS
ELISA 0.02-0.05 4-5MIN BLUE LINE IN THE
CONTROL AS WELL AS
IN RESULT WINDOW
28TH DAYS OF CYCLE
RAIOIMMUNOASSAY 0.002 3-4HRS 25TH DAY OF THE CYCLE
RADIO RECEPTOR ASSAY 0.001 1HR 22ND DAY OF CYCLE
19. Cont..
Time -8-11 days after conception. The test is not
reliable after 12 weeks.
Collection of urine -First voided urine in the
morning in a clean container.
Other uses of pregnancy tests
To Diagnosis of ectopic pregnancy
Monitoring pregnancy following IVF and embryo
transfer
Follow-up of cases of hydatidiform mole and
choriocarcinoma.
Limitations - Test accuracy is affected due to
presence of haemoglobin, albumin, LH and
immunological diseases.
27. Cont..
DOPPLER ULTRASOUND CAN PICK UP THE
FETAL HEART RATE RELIABLY BY 10TH
WEEK.
FOETAL GESTATIONAL AGE IS BEST
DETERMINED BY MEASURING CRL
BETWEEN 7-12 WEEKS.
28. Second trimester (13 to 28
weeks)
A. Subjective symptoms –
• Nausea, vomiting and frequency of
micturation usually subside.
• Quikening –
- between 18 to 20th weeks in
primigravidae
- between 16 to 18th weeks in
multigravidae
• Progressive enlargement of lower
30. 2. Breast changes-
More enlarged with prominent veins
under the skin.
Secondary areola appears at 20th
weeks.
Montgomery’s tubercle are prominent
and extend to the secondary areola.
Colostrum becomes thick and
yellowish by 16th week.
Variable degree of striae may be
32. •Abdominal examination-
a. Inspection –
• linea nigra becomes visible at 20th weeks.
• Striae (both pink & white) of varying degree are
visible in the lower abdomen.
33. b. Palpation -
Approximate duration of pregnancy can be
estimate by noting the fundal height in
relation to different level of the abdomen.
34.
35. Cont...
Braxton-hicks contraction are evident.
Palpation of fetal part by 20th weeks.
Active fetal movement
can be felt by placing
hand over the uterus.
External ballotment
is usually elicited.
36.
37.
38. c. Auscaltation -
FHS is most conclusive sign of
pregnancy.
With an ordinary stethoscope, it can be
detected between 18 to 20 weeks.
The rates varies from 140-160 bpm but
gradually settles down to 120-140 bpm
as pregnancy advanced.
Two other sounds confused with FHS are
:
39. • Vaginal examination -
a. Bluish discolouration of vulva,
vagina & cervix.
b. Increased softening of the cervix.
40. C. Ultrasonography -
At 18-20 weeks, routine
sonography diagnose about-
Foetal anatomy to detect any
malformation.
Placental localisation
Integrity of cervical canal
To determine gestational age by
measuring BPD, AC, FL,HC with
more accuracy in 2nd trimester.
41. D. Foetal skeletal shadow may
be visible at 16 week by
radiological evidence but this
diagnosis is not undertaken.
42. Third trimester (29 to 40 weeks)
A. Subjective symptoms -
Some mechanical discomfort such
as palpitation, dyspnea, heart burn
produce from early third trimester.
• Lightening occur at about 38th week.
• Frequency of micturition reappears
after lightening.
• Foetal movements are more
pronounced.
43. B. Objective signs -
Cutaneous changes are more prominent
with increased pigmentation.
Uterine shape is changed from cylindrical to
spherical beyond 36 week.
Braxton hicks contraction are more evident.
Foetal movements are easily felt.
Palpatation of the foetal parts and their
identification become much easier.
FHS is heard distinctly in areas
corresponding to the presentation &
position of the foetus.
44. Cont...
• FHS is not be audible in case of-
Maternal obesity
Polyhydramnios
Occipito-poterior position and IUD
• Fundal height –
The distance between the umbilicus and the
ensiform cartilage is divided into 3 equal part.
45. C. Ultrasonography -
Gestational age estimation by
BPD, HC, AC and FL is less
accurate .
Amniotic fluid assessment is
done to detect fetal well being.
If AFI is < 5=oligohydramnios or
If AFI is > 25=polyhydramnios.
To detect placental anatomy.