COMPRESSION COATING TABLET TECHNIQUE- INTRODUCTION, METHOD OF PREPARATION, APPROACHES, FACTORS AFFECTING CORE COATING, AND ADVANTAGES.

1. PHARMACY ACADEMY
BY. DR.MADEHA
COMPRESSION COATING TABLET TECHNIQUE
INTRODUCTION:
⮚It is a system in which entire surface of an inner core is
completely surrounded by the coat.
⮚These coats prevent drug released from core until the
polymeric or drug coat is entirely eroded, dissolved or
removed.
⮚The technique, a simple or unique technology, is used to
provide tablets with a programmable lag phase, followed by a
fast or rate -controlled drug released.
⮚Release of drug depends upon coating layer and core
composition.
⮚It has a solvent -free coating and facilitate manufacturing
process.
⮚It can be used to deliver one or more drugs.
⮚It is one of the approaches combines the features of both
controlled release tablets and immediate release tablets at
once.
⮚Provide barrier for substance, irritating to the stomach or one
inactivated by gastric juice.
This gives a for more accurate dose than in the case with
sugar coating

2. PHARMACY ACADEMY
BY. DR.MADEHA
METHODS OF PREPARATION:
⮚Firstly, core tablets are formulated which is small in size.
⮚Then for the upper coating large size punches are used.
⮚Half amount of coating material is placed in a die cavity.
⮚Then carefully place a core tablet on it.
⮚After that remaining half amount of coating material s taken.
⮚And final the tablet is compressed as compression coated
tablet
APPROACHES:
⮚Multiphasic release
⮚Delayed release
⮚Time controlled release
⮚pH controlled release
⮚Microbial controlled release
FACTORS AFFECTING CORE COATING:
⮚Tablet cores
⮚Drug solubility
⮚Tablet core formulation
⮚Compression coating
⮚Polymer type
⮚Particle size of polymer used
⮚Porosity or release modifier incorporated in coat
⮚Core-coat ratio
⮚Compression force

3. PHARMACY ACADEMY
BY. DR.MADEHA
ADVANTAGES:
⮚Elimination of the bitter taste and unpleasant smell of the
active pharmaceutical ingredient. (API)
⮚Elimination of water or other solvent in the coating
procedure and thereby decreasing the possible degradation
of API.
⮚Easier and more economical manufacturing process.
⮚Stability of moisture sensitive drugs can be improved by this
technique.
⮚Improves patient compliance by decreasing dosing frequency
⮚Both immediate and sustained release formulation can be
prepared in single unit tablet.
⮚A desirable plasma drug concentration is maintained by
continuous drug release.
⮚Compression coating tablet may include flavoring agents,
which could improve the patient’s compliance and
acceptance with the drug substance.
FORMULATION CONSIDERATION OF COMPRESSION-
COATING TECHNIQUES:
1.Compression-coating amount
2.Position of core in coated layer
3.Compression force and compressibility of materials
4.Interaction between drug and compression coat.